| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,766,906 | 302,990,000 | 15.48% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 16,727,455 | 256,432,000 | 13.10% | ||
| 3 | BVF INC/IL | 9,208,909 | 141,173,000 | 7.21% | ||
| 4 | ORBIMED ADVISORS LLC | 8,935,900 | 136,987,000 | 7.00% | ||
| 5 | MORGAN STANLEY | 8,084,120 | 123,929,000 | 6.33% | ||
| 6 | VANGUARD GROUP INC | 7,200,806 | 110,388,000 | 5.64% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 6,278,974 | 96,257,000 | 4.92% | ||
| 8 | STATE OF WISCONSIN INVESTMENT BOARD | 4,755,497 | 72,902,000 | 3.72% | ||
| 9 | BlackRock Fund Advisors | 4,720,980 | 72,373,000 | 3.70% | ||
| 10 | DEUTSCHE BANK AG\ | 3,904,596 | 59,855,000 | 3.06% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 3,367,745 | 51,628,000 | 2.64% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 3,269,932 | 50,128,000 | 2.56% | ||
| 13 | STATE STREET CORP | 2,782,787 | 42,662,000 | 2.18% | ||
| 14 | ORACLE INVESTMENT MANAGEMENT INC | 1,620,905 | 24,848,474 | 1.27% | ||
| 15 | Capital World Investors | 1,605,000 | 24,605,000 | 1.26% | ||
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,446,701 | 22,178,000 | 1.13% | ||
| 17 | CLOUGH CAPITAL PARTNERS L P | 1,372,200 | 21,036,000 | 1.07% | ||
| 18 | NORTHERN TRUST CORP | 1,300,625 | 19,938,000 | 1.02% | ||
| 19 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,167,581 | 17,899,000 | 0.91% | ||
| 20 | SECTOR GAMMA AS | 1,158,491 | 17,760,000 | 0.91% | ||
| 21 | FRED ALGER MANAGEMENT, LLC | 1,131,884 | 17,352,000 | 0.89% | ||
| 22 | FIL Ltd | 826,765 | 12,674,000 | 0.65% | ||
| 23 | Tekla Capital Management LLC | 768,050 | 11,774,000 | 0.60% | ||
| 24 | TURNER INVESTMENTS LLC | 767,670 | 11,768,000 | 0.60% | ||
| 25 | Tamarack Capital Management, LLC | 800,000 | 11,512,000 | 0.59% | ||
| 26 | AXA S.A. | 710,928 | 10,899,000 | 0.56% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 691,472 | 10,600,000 | 0.54% | ||
| 28 | CREDIT SUISSE AG/ | 657,195 | 10,075,000 | 0.51% | ||
| 29 | GOLDMAN SACHS GROUP INC | 600,581 | 9,207,000 | 0.47% | ||
| 30 | Bank of New York Mellon Corp | 573,298 | 8,789,000 | 0.45% | ||
| 31 | CAPITAL GUARDIAN TRUST CO | 555,053 | 8,509,000 | 0.43% | ||
| 32 | Visium Asset Management, LP | 508,000 | 7,788,000 | 0.40% | ||
| 33 | SHAPIRO ROBERT N | 485,974 | 7,450,000 | 0.38% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 469,077 | 7,191,000 | 0.37% | ||
| 35 | BAKER BROS. ADVISORS LP | 446,160 | 6,840,000 | 0.35% | ||
| 36 | SOUND ENERGY PARTNERS, INC. | 421,366 | 6,460,000 | 0.33% | ||
| 37 | SECTORAL ASSET MANAGEMENT INC | 360,724 | 5,530,000 | 0.28% | ||
| 38 | THRIVENT FINANCIAL FOR LUTHERANS | 337,386 | 5,172,000 | 0.26% | ||
| 39 | BlackRock Investment Management, LLC | 325,941 | 4,997,000 | 0.26% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 309,061 | 4,738,000 | 0.24% | ||
| 41 | ORBIMED ADVISORS LLC | 300,000 | 4,599,000 | 0.23% | Call | |
| 42 | GUGGENHEIM CAPITAL LLC | 268,751 | 4,120,000 | 0.21% | ||
| 43 | GOLDMAN SACHS GROUP INC | 250,000 | 3,833,000 | 0.20% | Put | |
| 44 | UBS AG | 220,000 | 3,373,000 | 0.17% | Put | |
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 218,182 | 3,345,000 | 0.17% | ||
| 46 | Artal Group S.A. | 216,879 | 3,325,000 | 0.17% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 209,300 | 3,209,000 | 0.16% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 208,400 | 3,195,000 | 0.16% | ||
| 49 | Hall Kathryn A. | 193,558 | 2,968,000 | 0.15% | ||
| 50 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 193,105 | 2,960,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
