| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,441,117 | 202,577,000 | 13.74% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 17,702,552 | 184,461,000 | 12.51% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 15,889,356 | 165,569,000 | 11.23% | ||
| 4 | ORBIMED ADVISORS LLC | 11,226,400 | 116,979,000 | 7.93% | ||
| 5 | VANGUARD GROUP INC | 8,549,108 | 89,081,000 | 6.04% | ||
| 6 | RUBRIC CAPITAL MANAGEMENT, LLC | 6,422,200 | 66,919,000 | 4.54% | ||
| 7 | BlackRock Fund Advisors | 5,864,667 | 61,110,000 | 4.14% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,129,310 | 53,447,000 | 3.62% | ||
| 9 | BVF INC/IL | 4,874,373 | 50,791,000 | 3.44% | ||
| 10 | BRIDGER MANAGEMENT, LLC | 4,748,776 | 49,482,000 | 3.36% | ||
| 11 | STATE STREET CORP | 4,074,629 | 42,455,000 | 2.88% | ||
| 12 | STATE OF WISCONSIN INVESTMENT BOARD | 3,864,380 | 40,267,000 | 2.73% | ||
| 13 | DEUTSCHE BANK AG\ | 3,266,118 | 34,029,000 | 2.31% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 3,046,674 | 31,746,000 | 2.15% | ||
| 15 | EverPoint Asset Management, LLC | 1,900,000 | 19,798,000 | 1.34% | ||
| 16 | SECTOR GAMMA AS | 1,826,191 | 19,029,000 | 1.29% | ||
| 17 | NORTHERN TRUST CORP | 1,671,538 | 17,417,000 | 1.18% | ||
| 18 | Point72 Asset Management, L.P. | 1,612,400 | 16,801,000 | 1.14% | ||
| 19 | Capital World Investors | 1,475,000 | 15,370,000 | 1.04% | ||
| 20 | CREDIT SUISSE AG/ | 1,439,314 | 14,998,000 | 1.02% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 1,228,245 | 12,798,000 | 0.87% | ||
| 22 | Lombard Odier Asset Management (USA) Corp | 1,220,835 | 12,721,000 | 0.86% | ||
| 23 | MORGAN STANLEY | 1,013,524 | 10,560,000 | 0.72% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 828,822 | 8,636,000 | 0.59% | ||
| 25 | Asset Management One Co., Ltd. | 847,748 | 8,333,000 | 0.57% | ||
| 26 | NORGES BANK | 774,338 | 8,069,000 | 0.55% | ||
| 27 | JPMORGAN CHASE & CO | 729,407 | 7,601,000 | 0.52% | ||
| 28 | Bank of New York Mellon Corp | 594,786 | 6,198,000 | 0.42% | ||
| 29 | GUGGENHEIM CAPITAL LLC | 505,463 | 5,267,000 | 0.36% | ||
| 30 | AXA S.A. | 435,132 | 4,534,000 | 0.31% | ||
| 31 | BlackRock Investment Management, LLC | 420,635 | 4,383,000 | 0.30% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 412,385 | 4,297,000 | 0.29% | ||
| 33 | THRIVENT FINANCIAL FOR LUTHERANS | 401,986 | 4,189,000 | 0.28% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 376,498 | 3,924,000 | 0.27% | ||
| 35 | CITADEL ADVISORS LLC | 325,483 | 3,391,000 | 0.23% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 298,302 | 3,108,000 | 0.21% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 263,300 | 2,744,000 | 0.19% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 229,611 | 2,393,000 | 0.16% | ||
| 39 | Artal Group S.A. | 216,879 | 2,260,000 | 0.15% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 208,160 | 2,169,000 | 0.15% | ||
| 41 | TEACHERS ADVISORS, LLC | 197,975 | 2,063,000 | 0.14% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 193,282 | 2,014,000 | 0.14% | ||
| 43 | Redmile Group, LLC | 190,789 | 1,988,000 | 0.13% | ||
| 44 | BLACKROCK ADVISORS LLC | 189,826 | 1,978,000 | 0.13% | ||
| 45 | D. E. Shaw & Co., Inc. | 182,388 | 1,900,000 | 0.13% | ||
| 46 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 178,578 | 1,860,000 | 0.13% | ||
| 47 | BAKER BROS. ADVISORS LP | 169,163 | 1,763,000 | 0.12% | ||
| 48 | GOLDMAN SACHS GROUP INC | 168,655 | 1,758,000 | 0.12% | ||
| 49 | Swiss National Bank | 163,300 | 1,702,000 | 0.12% | ||
| 50 | Broderick Brian C | 156,345 | 1,629,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
