| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,490,004 | 309,502,000 | 14.07% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 18,181,157 | 288,717,000 | 13.13% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 13,197,320 | 209,574,000 | 9.53% | ||
| 4 | ORBIMED ADVISORS LLC | 9,949,000 | 157,990,000 | 7.18% | ||
| 5 | VANGUARD GROUP INC | 9,658,333 | 153,374,000 | 6.97% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,770,893 | 139,282,000 | 6.33% | ||
| 7 | BlackRock Fund Advisors | 5,750,071 | 91,311,000 | 4.15% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,424,600 | 86,143,000 | 3.92% | ||
| 9 | BRIDGER MANAGEMENT, LLC | 3,924,333 | 62,318,000 | 2.83% | ||
| 10 | STATE STREET CORP | 3,427,936 | 54,440,000 | 2.48% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,335,616 | 52,970,000 | 2.41% | ||
| 12 | Consonance Capital Management LP | 3,296,539 | 52,349,000 | 2.38% | ||
| 13 | EcoR1 Capital, LLC | 2,810,315 | 44,628,000 | 2.03% | ||
| 14 | EverPoint Asset Management, LLC | 1,900,000 | 30,172,000 | 1.37% | ||
| 15 | NORTHERN TRUST CORP | 1,765,420 | 28,035,000 | 1.27% | ||
| 16 | SECTOR GAMMA AS | 1,960,548 | 27,801,000 | 1.26% | ||
| 17 | LOOMIS SAYLES & CO L P | 1,546,772 | 24,563,000 | 1.12% | ||
| 18 | CREDIT SUISSE AG/ | 1,480,763 | 23,515,000 | 1.07% | ||
| 19 | Granahan Investment Management, LLC | 1,408,000 | 22,359,000 | 1.02% | ||
| 20 | GOLDMAN SACHS GROUP INC | 1,356,137 | 21,535,000 | 0.98% | ||
| 21 | NORGES BANK | 1,060,542 | 16,085,000 | 0.73% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 987,867 | 15,686,000 | 0.71% | ||
| 23 | Point72 Asset Management, L.P. | 953,927 | 15,148,000 | 0.69% | ||
| 24 | BLUE JAY CAPITAL MANAGEMENT, LLC | 725,000 | 11,513,000 | 0.52% | ||
| 25 | BNP Paribas Asset Management Holding S.A. | 681,828 | 10,827,000 | 0.49% | ||
| 26 | Asset Management One Co., Ltd. | 622,699 | 9,589,000 | 0.44% | ||
| 27 | STATE OF WISCONSIN INVESTMENT BOARD | 600,000 | 9,528,000 | 0.43% | ||
| 28 | Bank of New York Mellon Corp | 581,227 | 9,231,000 | 0.42% | ||
| 29 | Spark Investment Management LLC | 568,100 | 9,021,000 | 0.41% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 552,724 | 8,778,000 | 0.40% | ||
| 31 | D. E. Shaw & Co., Inc. | 519,023 | 8,242,000 | 0.37% | ||
| 32 | BlackRock Investment Management, LLC | 486,291 | 7,722,000 | 0.35% | ||
| 33 | Redmile Group, LLC | 408,462 | 6,486,000 | 0.29% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 394,140 | 6,259,000 | 0.28% | ||
| 35 | OXFORD ASSET MANAGEMENT LLP | 391,981 | 6,225,000 | 0.28% | ||
| 36 | CLEARBRIDGE, LLC | 390,435 | 6,200,000 | 0.28% | ||
| 37 | DEUTSCHE BANK AG\ | 388,530 | 6,168,000 | 0.28% | ||
| 38 | WOLVERINE ASSET MANAGEMENT LLC | 361,300 | 5,737,000 | 0.26% | Put | |
| 39 | MILLENNIUM MANAGEMENT LLC | 342,321 | 5,436,000 | 0.25% | ||
| 40 | BLACKROCK ADVISORS LLC | 330,843 | 5,254,000 | 0.24% | ||
| 41 | WADDELL & REED FINANCIAL INC | 323,900 | 5,144,000 | 0.23% | ||
| 42 | MACQUARIE GROUP LTD | 320,000 | 5,082,000 | 0.23% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 273,810 | 4,348,000 | 0.20% | ||
| 44 | Fisher Asset Management, LLC | 242,450 | 3,850,000 | 0.18% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 225,300 | 3,578,000 | 0.16% | ||
| 46 | CITADEL ADVISORS LLC | 223,997 | 3,557,000 | 0.16% | ||
| 47 | TEACHERS ADVISORS, LLC | 223,737 | 3,553,000 | 0.16% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 223,660 | 3,552,000 | 0.16% | ||
| 49 | PICTET ASSET MANAGEMENT LTD | 220,300 | 3,498,000 | 0.16% | ||
| 50 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 219,190 | 3,481,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
