| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,755,935 | 316,095,000 | 14.66% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 17,529,199 | 280,467,000 | 13.00% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 14,885,648 | 238,186,000 | 11.04% | ||
| 4 | ORBIMED ADVISORS LLC | 12,012,100 | 192,194,000 | 8.91% | ||
| 5 | VANGUARD GROUP INC | 7,997,806 | 127,965,000 | 5.93% | ||
| 6 | MORGAN STANLEY | 7,179,439 | 114,871,000 | 5.33% | ||
| 7 | DEUTSCHE BANK AG\ | 6,665,883 | 106,652,000 | 4.95% | ||
| 8 | BlackRock Fund Advisors | 5,666,614 | 90,666,000 | 4.20% | ||
| 9 | STATE STREET CORP | 3,357,894 | 53,730,000 | 2.49% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 3,222,678 | 51,563,000 | 2.39% | ||
| 11 | STATE OF WISCONSIN INVESTMENT BOARD | 3,107,980 | 49,728,000 | 2.31% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,630,248 | 42,084,000 | 1.95% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 2,379,282 | 38,069,000 | 1.77% | ||
| 14 | BVF INC/IL | 2,171,108 | 34,738,000 | 1.61% | ||
| 15 | NORTHERN TRUST CORP | 1,622,430 | 25,959,000 | 1.20% | ||
| 16 | Capital World Investors | 1,475,000 | 23,600,000 | 1.09% | ||
| 17 | FRED ALGER MANAGEMENT, LLC | 1,440,722 | 23,052,000 | 1.07% | ||
| 18 | Asset Management One Co., Ltd. | 1,157,428 | 19,132,000 | 0.89% | ||
| 19 | JPMORGAN CHASE & CO | 1,191,963 | 19,071,000 | 0.88% | ||
| 20 | SECTOR GAMMA AS | 1,162,191 | 18,595,000 | 0.86% | ||
| 21 | NORGES BANK | 1,028,680 | 16,459,000 | 0.76% | ||
| 22 | EcoR1 Capital, LLC | 900,000 | 14,400,000 | 0.67% | ||
| 23 | D. E. Shaw & Co., Inc. | 874,918 | 13,999,000 | 0.65% | ||
| 24 | BRIDGER MANAGEMENT, LLC | 840,479 | 13,448,000 | 0.62% | ||
| 25 | Tekla Capital Management LLC | 768,050 | 12,289,000 | 0.57% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 754,644 | 12,073,000 | 0.56% | ||
| 27 | Point72 Asset Management, L.P. | 750,000 | 12,000,000 | 0.56% | ||
| 28 | Bank of New York Mellon Corp | 656,642 | 10,506,000 | 0.49% | ||
| 29 | EverPoint Asset Management, LLC | 600,000 | 9,600,000 | 0.45% | ||
| 30 | EcoR1 Capital, LLC | 5,000 | 8,000,000 | 0.37% | Call | |
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 438,336 | 7,013,000 | 0.33% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 426,023 | 6,816,000 | 0.32% | ||
| 33 | AXA S.A. | 418,624 | 6,698,000 | 0.31% | ||
| 34 | GUGGENHEIM CAPITAL LLC | 405,404 | 6,486,000 | 0.30% | ||
| 35 | GOLDMAN SACHS GROUP INC | 360,101 | 5,762,000 | 0.27% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 341,336 | 5,462,000 | 0.25% | ||
| 37 | BlackRock Investment Management, LLC | 330,241 | 5,284,000 | 0.24% | ||
| 38 | THRIVENT FINANCIAL FOR LUTHERANS | 328,986 | 5,264,000 | 0.24% | ||
| 39 | EverPoint Asset Management, LLC | 300,000 | 4,800,000 | 0.22% | Call | |
| 40 | CITADEL ADVISORS LLC | 299,582 | 4,793,000 | 0.22% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 263,300 | 4,389,000 | 0.20% | ||
| 42 | Allianz Asset Management GmbH | 273,750 | 4,380,000 | 0.20% | ||
| 43 | Granahan Investment Management, LLC | 230,800 | 3,693,000 | 0.17% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 220,300 | 3,525,000 | 0.16% | Call | |
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 218,577 | 3,497,000 | 0.16% | ||
| 46 | Artal Group S.A. | 216,879 | 3,470,000 | 0.16% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 208,400 | 3,334,000 | 0.15% | ||
| 48 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 193,105 | 3,090,000 | 0.14% | ||
| 49 | PARADIGM ASSET MANAGEMENT CO LLC | 192,500 | 3,080,000 | 0.14% | ||
| 50 | TEACHERS ADVISORS, LLC | 183,932 | 2,943,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
