| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,755,935 | 302,661,000 | 14.78% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 17,289,225 | 264,871,000 | 12.94% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 14,286,607 | 218,884,000 | 10.69% | ||
| 4 | ORBIMED ADVISORS LLC | 12,012,100 | 184,025,000 | 8.99% | ||
| 5 | MORGAN STANLEY | 7,726,761 | 118,374,000 | 5.78% | ||
| 6 | VANGUARD GROUP INC | 7,543,747 | 115,570,000 | 5.64% | ||
| 7 | DEUTSCHE BANK AG\ | 7,018,198 | 107,517,000 | 5.25% | ||
| 8 | BlackRock Fund Advisors | 5,336,875 | 81,761,000 | 3.99% | ||
| 9 | BVF INC/IL | 5,093,810 | 78,037,000 | 3.81% | ||
| 10 | STATE OF WISCONSIN INVESTMENT BOARD | 3,728,485 | 57,120,000 | 2.79% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,220,479 | 49,338,000 | 2.41% | ||
| 12 | STATE STREET CORP | 2,965,658 | 45,436,000 | 2.22% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 2,667,575 | 40,867,000 | 2.00% | ||
| 14 | FRED ALGER MANAGEMENT, LLC | 1,881,312 | 28,822,000 | 1.41% | ||
| 15 | Capital World Investors | 1,605,000 | 25,006,000 | 1.22% | ||
| 16 | NORTHERN TRUST CORP | 1,597,172 | 24,469,000 | 1.19% | ||
| 17 | Point72 Asset Management, L.P. | 1,500,100 | 22,982,000 | 1.12% | ||
| 18 | SECTOR GAMMA AS | 1,145,191 | 17,544,000 | 0.86% | ||
| 19 | Asset Management One Co., Ltd. | 1,159,005 | 17,338,000 | 0.85% | ||
| 20 | PRICE T ROWE ASSOCIATES INC /MD/ | 970,620 | 14,870,000 | 0.73% | ||
| 21 | EcoR1 Capital, LLC | 900,000 | 13,788,000 | 0.67% | ||
| 22 | SENZAR ASSET MANAGEMENT, LLC | 781,800 | 11,977,000 | 0.58% | ||
| 23 | Tekla Capital Management LLC | 768,050 | 11,767,000 | 0.57% | ||
| 24 | GOLDMAN SACHS GROUP INC | 756,287 | 11,587,000 | 0.57% | ||
| 25 | D. E. Shaw & Co., Inc. | 720,231 | 11,034,000 | 0.54% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 715,886 | 10,967,000 | 0.54% | ||
| 27 | Bank of New York Mellon Corp | 638,339 | 9,780,000 | 0.48% | ||
| 28 | EverPoint Asset Management, LLC | 500,000 | 7,660,000 | 0.37% | ||
| 29 | AXA S.A. | 466,883 | 7,153,000 | 0.35% | ||
| 30 | SHAPIRO ROBERT N | 465,644 | 7,134,000 | 0.35% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 436,893 | 6,693,000 | 0.33% | ||
| 32 | Lombard Odier Asset Management (USA) Corp | 406,711 | 6,231,000 | 0.30% | ||
| 33 | BAKER BROS. ADVISORS LP | 346,160 | 5,303,000 | 0.26% | ||
| 34 | GUGGENHEIM CAPITAL LLC | 335,289 | 5,137,000 | 0.25% | ||
| 35 | THRIVENT FINANCIAL FOR LUTHERANS | 329,586 | 5,050,000 | 0.25% | ||
| 36 | Forward Management, LLC | 370,873 | 5,019,000 | 0.25% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 325,133 | 4,982,000 | 0.24% | ||
| 38 | BlackRock Investment Management, LLC | 324,609 | 4,973,000 | 0.24% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 263,300 | 4,389,000 | 0.21% | ||
| 40 | Allianz Asset Management GmbH | 273,750 | 4,194,000 | 0.20% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 222,177 | 3,404,000 | 0.17% | ||
| 42 | Artal Group S.A. | 216,879 | 3,323,000 | 0.16% | ||
| 43 | ALLIANCEBERNSTEIN L.P. | 208,400 | 3,193,000 | 0.16% | ||
| 44 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 193,105 | 2,959,000 | 0.14% | ||
| 45 | PARADIGM ASSET MANAGEMENT CO LLC | 190,500 | 2,918,460 | 0.14% | ||
| 46 | TEACHERS ADVISORS, LLC | 181,811 | 2,785,000 | 0.14% | ||
| 47 | Broderick Brian C | 162,345 | 2,487,000 | 0.12% | ||
| 48 | WELLS FARGO & COMPANY/MN | 152,443 | 2,335,000 | 0.11% | ||
| 49 | Nationwide Fund Advisors | 131,724 | 2,018,000 | 0.10% | ||
| 50 | Swiss National Bank | 128,700 | 1,972,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
