| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,271,669 | 251,977,000 | 13.87% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 17,977,429 | 235,055,000 | 12.94% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 14,162,327 | 185,163,000 | 10.19% | ||
| 4 | ORBIMED ADVISORS LLC | 9,949,000 | 130,083,000 | 7.16% | ||
| 5 | VANGUARD GROUP INC | 9,379,525 | 122,637,000 | 6.75% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 7,501,583 | 98,083,000 | 5.40% | ||
| 7 | BRIDGER MANAGEMENT, LLC | 5,917,663 | 77,373,000 | 4.26% | ||
| 8 | BlackRock Fund Advisors | 5,506,855 | 72,002,000 | 3.96% | ||
| 9 | Consonance Capital Management LP | 4,929,139 | 64,448,000 | 3.55% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 3,293,499 | 43,062,000 | 2.37% | ||
| 11 | STATE STREET CORP | 3,229,227 | 42,222,000 | 2.32% | ||
| 12 | EverPoint Asset Management, LLC | 2,500,000 | 32,687,000 | 1.80% | ||
| 13 | EcoR1 Capital, LLC | 2,430,451 | 31,778,000 | 1.75% | ||
| 14 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,900,000 | 24,843,000 | 1.37% | ||
| 15 | LOOMIS SAYLES & CO L P | 1,848,031 | 24,163,000 | 1.33% | ||
| 16 | SECTOR GAMMA AS | 1,769,368 | 23,134,000 | 1.27% | ||
| 17 | NORTHERN TRUST CORP | 1,768,413 | 23,122,000 | 1.27% | ||
| 18 | STATE OF WISCONSIN INVESTMENT BOARD | 1,609,897 | 21,049,000 | 1.16% | ||
| 19 | CREDIT SUISSE AG/ | 1,585,867 | 20,735,000 | 1.14% | ||
| 20 | Point72 Asset Management, L.P. | 1,167,183 | 15,261,000 | 0.84% | ||
| 21 | Granahan Investment Management, LLC | 1,129,000 | 14,762,000 | 0.81% | ||
| 22 | Carlson Capital, L.P. | 1,100,000 | 14,382,000 | 0.79% | ||
| 23 | DEUTSCHE BANK AG\ | 1,048,613 | 13,708,000 | 0.75% | ||
| 24 | WOLVERINE ASSET MANAGEMENT LLC | 1,008,800 | 13,190,000 | 0.73% | Put | |
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 954,033 | 12,473,000 | 0.69% | ||
| 26 | BLUE JAY CAPITAL MANAGEMENT, LLC | 821,070 | 10,735,000 | 0.59% | ||
| 27 | Asset Management One Co., Ltd. | 799,751 | 10,372,000 | 0.57% | ||
| 28 | NORGES BANK | 756,734 | 9,894,000 | 0.54% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 650,472 | 8,505,000 | 0.47% | ||
| 30 | Bank of New York Mellon Corp | 595,939 | 7,792,000 | 0.43% | ||
| 31 | JPMORGAN CHASE & CO | 553,489 | 7,237,000 | 0.40% | ||
| 32 | EverPoint Asset Management, LLC | 500,000 | 6,538,000 | 0.36% | Call | |
| 33 | BlackRock Investment Management, LLC | 481,700 | 6,298,000 | 0.35% | ||
| 34 | Redmile Group, LLC | 442,711 | 5,788,000 | 0.32% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 435,942 | 5,700,000 | 0.31% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 399,290 | 5,221,000 | 0.29% | ||
| 37 | CLEARBRIDGE, LLC | 390,435 | 5,105,000 | 0.28% | ||
| 38 | GOLDMAN SACHS GROUP INC | 368,412 | 4,817,000 | 0.27% | ||
| 39 | Spark Investment Management LLC | 346,100 | 4,525,000 | 0.25% | ||
| 40 | TWO SIGMA INVESTMENTS, LP | 336,914 | 4,405,000 | 0.24% | ||
| 41 | BLACKROCK ADVISORS LLC | 305,902 | 4,000,000 | 0.22% | ||
| 42 | A.R.T. Advisors, LLC | 304,215 | 3,977,000 | 0.22% | ||
| 43 | D. E. Shaw & Co., Inc. | 295,455 | 3,863,000 | 0.21% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 271,710 | 3,553,000 | 0.20% | ||
| 45 | Fisher Asset Management, LLC | 242,450 | 3,205,000 | 0.18% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 240,800 | 3,149,000 | 0.17% | ||
| 47 | GUGGENHEIM CAPITAL LLC | 226,387 | 2,960,000 | 0.16% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 223,660 | 2,924,000 | 0.16% | ||
| 49 | TEACHERS ADVISORS, LLC | 221,344 | 2,894,000 | 0.16% | ||
| 50 | Artal Group S.A. | 216,879 | 2,836,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
