| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,372,317 | 224,525,000 | 13.80% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 17,778,210 | 206,050,000 | 12.67% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 15,761,668 | 182,672,000 | 11.23% | ||
| 4 | ORBIMED ADVISORS LLC | 11,226,400 | 130,114,000 | 8.00% | ||
| 5 | VANGUARD GROUP INC | 8,810,823 | 102,117,000 | 6.28% | ||
| 6 | RUBRIC CAPITAL MANAGEMENT, LLC | 6,422,200 | 74,433,000 | 4.58% | ||
| 7 | BlackRock Fund Advisors | 5,575,596 | 64,621,000 | 3.97% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,118,010 | 59,318,000 | 3.65% | ||
| 9 | BRIDGER MANAGEMENT, LLC | 4,944,594 | 57,308,000 | 3.52% | ||
| 10 | Redmile Group, LLC | 3,671,344 | 42,551,000 | 2.62% | ||
| 11 | STATE STREET CORP | 3,392,238 | 39,316,000 | 2.42% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 3,219,962 | 37,319,000 | 2.29% | ||
| 13 | STATE OF WISCONSIN INVESTMENT BOARD | 3,041,686 | 35,253,000 | 2.17% | ||
| 14 | BVF INC/IL | 2,935,975 | 34,028,000 | 2.09% | ||
| 15 | EverPoint Asset Management, LLC | 2,350,000 | 27,237,000 | 1.67% | ||
| 16 | SECTOR GAMMA AS | 1,974,421 | 22,884,000 | 1.41% | ||
| 17 | NORTHERN TRUST CORP | 1,709,052 | 19,808,000 | 1.22% | ||
| 18 | DEUTSCHE BANK AG\ | 1,668,824 | 19,340,000 | 1.19% | ||
| 19 | Point72 Asset Management, L.P. | 1,537,900 | 17,824,000 | 1.10% | ||
| 20 | LOOMIS SAYLES & CO L P | 1,519,512 | 17,611,000 | 1.08% | ||
| 21 | CREDIT SUISSE AG/ | 1,461,380 | 16,937,000 | 1.04% | ||
| 22 | MORGAN STANLEY | 963,822 | 11,170,000 | 0.69% | ||
| 23 | NORGES BANK | 885,738 | 10,266,000 | 0.63% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 874,584 | 10,136,000 | 0.62% | ||
| 25 | Asset Management One Co., Ltd. | 825,823 | 9,959,000 | 0.61% | ||
| 26 | EcoR1 Capital, LLC | 821,531 | 9,522,000 | 0.59% | ||
| 27 | JPMORGAN CHASE & CO | 754,529 | 8,745,000 | 0.54% | ||
| 28 | Lombard Odier Asset Management (USA) Corp | 602,271 | 6,980,000 | 0.43% | ||
| 29 | Bank of New York Mellon Corp | 597,171 | 6,921,000 | 0.43% | ||
| 30 | AXA S.A. | 431,420 | 5,000,000 | 0.31% | ||
| 31 | BlackRock Investment Management, LLC | 422,802 | 4,900,000 | 0.30% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 409,780 | 4,750,000 | 0.29% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 407,149 | 4,719,000 | 0.29% | ||
| 34 | THRIVENT FINANCIAL FOR LUTHERANS | 401,986 | 4,659,000 | 0.29% | ||
| 35 | GUGGENHEIM CAPITAL LLC | 369,971 | 4,288,000 | 0.26% | ||
| 36 | OXFORD ASSET MANAGEMENT LLP | 357,495 | 4,235,000 | 0.26% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 292,512 | 3,390,000 | 0.21% | ||
| 38 | D. E. Shaw & Co., Inc. | 290,331 | 3,365,000 | 0.21% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 263,300 | 3,052,000 | 0.19% | ||
| 40 | RENAISSANCE TECHNOLOGIES LLC | 242,553 | 2,811,000 | 0.17% | ||
| 41 | TWO SIGMA INVESTMENTS, LP | 236,926 | 2,746,000 | 0.17% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 233,338 | 2,704,000 | 0.17% | ||
| 43 | Artal Group S.A. | 216,879 | 2,514,000 | 0.15% | ||
| 44 | TEACHERS ADVISORS, LLC | 197,975 | 2,295,000 | 0.14% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 191,461 | 2,219,000 | 0.14% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 208,160 | 2,169,000 | 0.13% | ||
| 47 | PICTET ASSET MANAGEMENT LTD | 184,200 | 2,135,000 | 0.13% | ||
| 48 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 183,578 | 2,127,000 | 0.13% | ||
| 49 | BAKER BROS. ADVISORS LP | 169,163 | 1,961,000 | 0.12% | ||
| 50 | ALPS ADVISORS INC | 167,286 | 1,939,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
