| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,766,906 | 243,524,000 | 14.91% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 16,644,557 | 205,061,000 | 12.55% | ||
| 3 | BVF INC/IL | 9,303,003 | 114,613,000 | 7.02% | ||
| 4 | MORGAN STANLEY | 8,129,015 | 100,150,000 | 6.13% | ||
| 5 | VANGUARD GROUP INC | 7,145,775 | 88,037,000 | 5.39% | ||
| 6 | DEUTSCHE BANK AG\ | 6,362,424 | 78,382,000 | 4.80% | ||
| 7 | STATE OF WISCONSIN INVESTMENT BOARD | 6,300,000 | 77,616,000 | 4.75% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 5,947,823 | 73,277,000 | 4.49% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 5,308,406 | 65,400,000 | 4.00% | ||
| 10 | BlackRock Fund Advisors | 4,959,931 | 61,106,000 | 3.74% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 4,642,182 | 57,192,000 | 3.50% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 3,170,349 | 39,059,000 | 2.39% | ||
| 13 | STATE STREET CORP | 3,148,354 | 38,787,000 | 2.37% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,846,736 | 22,752,000 | 1.39% | ||
| 15 | ORACLE INVESTMENT MANAGEMENT INC | 1,846,005 | 22,742,782 | 1.39% | ||
| 16 | NORTHERN TRUST CORP | 1,728,862 | 21,299,000 | 1.30% | ||
| 17 | Capital World Investors | 1,650,000 | 20,328,000 | 1.24% | ||
| 18 | WADDELL & REED FINANCIAL INC | 1,287,722 | 15,865,000 | 0.97% | ||
| 19 | CAPITAL GUARDIAN TRUST CO | 1,270,733 | 15,655,000 | 0.96% | ||
| 20 | FRED ALGER MANAGEMENT, LLC | 1,142,091 | 14,071,000 | 0.86% | ||
| 21 | TURNER INVESTMENTS LLC | 1,126,790 | 13,882,000 | 0.85% | ||
| 22 | ORBIMED ADVISORS LLC | 1,082,100 | 13,331,000 | 0.82% | ||
| 23 | SECTOR GAMMA AS | 1,026,991 | 12,653,000 | 0.77% | ||
| 24 | CLOUGH CAPITAL PARTNERS L P | 946,600 | 11,662,000 | 0.71% | ||
| 25 | VHCP Management, LLC | 900,000 | 11,088,000 | 0.68% | ||
| 26 | SHAPIRO ROBERT N | 840,914 | 10,360,000 | 0.63% | ||
| 27 | FIL Ltd | 826,765 | 10,186,000 | 0.62% | ||
| 28 | Tekla Capital Management LLC | 768,050 | 9,462,000 | 0.58% | ||
| 29 | AXA S.A. | 730,244 | 8,997,000 | 0.55% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 663,089 | 8,169,000 | 0.50% | ||
| 31 | GOLDMAN SACHS GROUP INC | 610,393 | 7,520,000 | 0.46% | ||
| 32 | NORGES BANK | 573,338 | 7,064,000 | 0.43% | ||
| 33 | Bank of New York Mellon Corp | 545,501 | 6,720,000 | 0.41% | ||
| 34 | Visium Asset Management, LP | 511,000 | 6,296,000 | 0.39% | ||
| 35 | APEX CAPITAL, LLC | 450,000 | 5,544,000 | 0.34% | ||
| 36 | BAKER BROS. ADVISORS LP | 446,160 | 5,497,000 | 0.34% | ||
| 37 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 437,549 | 5,391,000 | 0.33% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 410,061 | 5,052,000 | 0.31% | ||
| 39 | SOUND ENERGY PARTNERS, INC. | 347,800 | 4,285,000 | 0.26% | ||
| 40 | GUGGENHEIM CAPITAL LLC | 335,535 | 4,134,000 | 0.25% | ||
| 41 | ORBIMED ADVISORS LLC | 300,000 | 3,696,000 | 0.23% | Call | |
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 293,861 | 3,621,000 | 0.22% | ||
| 43 | BlackRock Investment Management, LLC | 293,695 | 3,618,000 | 0.22% | ||
| 44 | JPMORGAN CHASE & CO | 265,641 | 3,273,000 | 0.20% | ||
| 45 | GOLDMAN SACHS GROUP INC | 250,000 | 3,080,000 | 0.19% | Put | |
| 46 | PICTET ASSET MANAGEMENT LTD | 248,900 | 3,066,000 | 0.19% | ||
| 47 | TCW GROUP INC | 237,917 | 2,931,000 | 0.18% | ||
| 48 | Artal Group S.A. | 216,879 | 2,672,000 | 0.16% | ||
| 49 | ProShare Advisors LLC | 197,149 | 2,429,000 | 0.15% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 194,402 | 2,395,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
