| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,118,089 | 209,152,000 | 13.52% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 17,843,324 | 195,206,000 | 12.62% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 16,390,756 | 179,337,000 | 11.59% | ||
| 4 | ORBIMED ADVISORS LLC | 11,550,400 | 126,361,000 | 8.17% | ||
| 5 | VANGUARD GROUP INC | 9,097,867 | 99,531,000 | 6.43% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 6,705,210 | 73,355,000 | 4.74% | ||
| 7 | BlackRock Fund Advisors | 5,534,320 | 60,545,000 | 3.91% | ||
| 8 | BRIDGER MANAGEMENT, LLC | 5,178,628 | 56,654,000 | 3.66% | ||
| 9 | Consonance Capital Management LP | 4,944,139 | 54,089,000 | 3.50% | ||
| 10 | Redmile Group, LLC | 4,320,192 | 47,263,000 | 3.06% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,229,012 | 35,325,000 | 2.28% | ||
| 12 | STATE STREET CORP | 3,045,704 | 33,321,000 | 2.15% | ||
| 13 | EverPoint Asset Management, LLC | 2,710,000 | 29,647,000 | 1.92% | ||
| 14 | SECTOR GAMMA AS | 2,486,757 | 27,205,000 | 1.76% | ||
| 15 | STATE OF WISCONSIN INVESTMENT BOARD | 2,419,897 | 26,474,000 | 1.71% | ||
| 16 | EcoR1 Capital, LLC | 2,061,417 | 22,552,000 | 1.46% | ||
| 17 | BVF INC/IL | 1,755,745 | 19,208,000 | 1.24% | ||
| 18 | NORTHERN TRUST CORP | 1,739,591 | 19,031,000 | 1.23% | ||
| 19 | LOOMIS SAYLES & CO L P | 1,649,172 | 18,042,000 | 1.17% | ||
| 20 | DEUTSCHE BANK AG\ | 1,624,351 | 17,769,000 | 1.15% | ||
| 21 | CREDIT SUISSE AG/ | 1,581,186 | 17,298,000 | 1.12% | ||
| 22 | Point72 Asset Management, L.P. | 1,180,500 | 12,915,000 | 0.83% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 932,729 | 10,204,000 | 0.66% | ||
| 24 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 900,000 | 9,846,000 | 0.64% | ||
| 25 | Asset Management One Co., Ltd. | 836,470 | 8,757,000 | 0.57% | ||
| 26 | JPMORGAN CHASE & CO | 764,631 | 8,365,000 | 0.54% | ||
| 27 | NORGES BANK | 743,134 | 8,130,000 | 0.53% | ||
| 28 | Bank of New York Mellon Corp | 586,646 | 6,418,000 | 0.41% | ||
| 29 | MORGAN STANLEY | 484,217 | 5,297,000 | 0.34% | ||
| 30 | BlackRock Investment Management, LLC | 440,781 | 4,822,000 | 0.31% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 418,403 | 4,578,000 | 0.30% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 401,483 | 4,392,000 | 0.28% | ||
| 33 | CLEARBRIDGE, LLC | 369,085 | 4,038,000 | 0.26% | ||
| 34 | THRIVENT FINANCIAL FOR LUTHERANS | 357,786 | 3,914,000 | 0.25% | ||
| 35 | D. E. Shaw & Co., Inc. | 323,002 | 3,534,000 | 0.23% | ||
| 36 | BLACKROCK ADVISORS LLC | 299,831 | 3,280,000 | 0.21% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 267,522 | 2,927,000 | 0.19% | ||
| 38 | GUGGENHEIM CAPITAL LLC | 250,699 | 2,743,000 | 0.18% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 248,300 | 2,716,000 | 0.18% | ||
| 40 | Fisher Asset Management, LLC | 235,675 | 2,656,000 | 0.17% | ||
| 41 | Artal Group S.A. | 216,879 | 2,373,000 | 0.15% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 208,160 | 2,277,000 | 0.15% | ||
| 43 | OXFORD ASSET MANAGEMENT LLP | 200,782 | 2,197,000 | 0.14% | ||
| 44 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 200,030 | 2,189,000 | 0.14% | ||
| 45 | Swiss National Bank | 205,800 | 2,172,000 | 0.14% | ||
| 46 | A.R.T. Advisors, LLC | 198,615 | 2,172,000 | 0.14% | ||
| 47 | TEACHERS ADVISORS, LLC | 197,975 | 2,166,000 | 0.14% | ||
| 48 | Spark Investment Management LLC | 197,800 | 2,163,000 | 0.14% | ||
| 49 | TD ASSET MANAGEMENT INC | 193,900 | 2,121,000 | 0.14% | ||
| 50 | GOLDMAN SACHS GROUP INC | 190,274 | 2,082,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
