| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,766,906 | 256,070,000 | 14.91% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 16,921,306 | 219,216,000 | 12.76% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 13,053,528 | 169,107,000 | 9.85% | ||
| 4 | ORBIMED ADVISORS LLC | 12,012,100 | 155,617,000 | 9.06% | ||
| 5 | MORGAN STANLEY | 8,054,267 | 104,343,000 | 6.07% | ||
| 6 | VANGUARD GROUP INC | 7,316,217 | 94,781,000 | 5.52% | ||
| 7 | BVF INC/IL | 5,597,065 | 72,510,000 | 4.22% | ||
| 8 | DEUTSCHE BANK AG\ | 5,361,005 | 69,449,000 | 4.04% | ||
| 9 | STATE OF WISCONSIN INVESTMENT BOARD | 4,873,497 | 63,136,000 | 3.68% | ||
| 10 | BlackRock Fund Advisors | 4,779,331 | 61,916,000 | 3.60% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,194,932 | 41,390,000 | 2.41% | ||
| 12 | STATE STREET CORP | 2,996,085 | 38,812,000 | 2.26% | ||
| 13 | NORTHERN TRUST CORP | 1,662,370 | 21,535,000 | 1.25% | ||
| 14 | FRED ALGER MANAGEMENT, LLC | 1,625,438 | 21,058,000 | 1.23% | ||
| 15 | Capital World Investors | 1,605,000 | 20,793,000 | 1.21% | ||
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,416,701 | 18,353,000 | 1.07% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 1,337,228 | 17,324,000 | 1.01% | ||
| 18 | Point72 Asset Management, L.P. | 1,292,500 | 16,744,000 | 0.97% | ||
| 19 | SECTOR GAMMA AS | 1,138,291 | 14,747,000 | 0.86% | ||
| 20 | Asset Management One Co., Ltd. | 892,055 | 11,944,000 | 0.70% | ||
| 21 | FIL Ltd | 826,765 | 10,711,000 | 0.62% | ||
| 22 | Tekla Capital Management LLC | 768,050 | 9,950,000 | 0.58% | ||
| 23 | AXA S.A. | 717,990 | 9,302,000 | 0.54% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 698,339 | 9,046,000 | 0.53% | ||
| 25 | CLOUGH CAPITAL PARTNERS L P | 630,700 | 8,171,000 | 0.48% | ||
| 26 | Bank of New York Mellon Corp | 606,627 | 7,859,000 | 0.46% | ||
| 27 | Visium Asset Management, LP | 550,000 | 7,125,000 | 0.41% | ||
| 28 | CAPITAL GUARDIAN TRUST CO | 543,711 | 7,044,000 | 0.41% | ||
| 29 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 541,576 | 7,016,000 | 0.41% | ||
| 30 | D. E. Shaw & Co., Inc. | 535,196 | 6,933,000 | 0.40% | ||
| 31 | SHAPIRO ROBERT N | 485,974 | 6,296,000 | 0.37% | ||
| 32 | WADDELL & REED FINANCIAL INC | 480,000 | 6,218,000 | 0.36% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 461,084 | 5,973,000 | 0.35% | ||
| 34 | SOUND ENERGY PARTNERS, INC. | 400,566 | 5,189,000 | 0.30% | ||
| 35 | GOLDMAN SACHS GROUP INC | 385,599 | 4,995,000 | 0.29% | ||
| 36 | BAKER BROS. ADVISORS LP | 346,160 | 4,485,000 | 0.26% | ||
| 37 | THRIVENT FINANCIAL FOR LUTHERANS | 337,386 | 4,371,000 | 0.25% | ||
| 38 | BlackRock Investment Management, LLC | 327,850 | 4,247,000 | 0.25% | ||
| 39 | Lombard Odier Asset Management (USA) Corp | 325,000 | 4,210,000 | 0.25% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 313,556 | 4,063,000 | 0.24% | ||
| 41 | GUGGENHEIM CAPITAL LLC | 307,222 | 3,980,000 | 0.23% | ||
| 42 | GOLDMAN SACHS GROUP INC | 300,000 | 3,887,000 | 0.23% | Put | |
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 259,025 | 3,356,000 | 0.20% | ||
| 44 | Forward Management, LLC | 244,497 | 3,297,000 | 0.19% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 234,315 | 3,036,000 | 0.18% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 228,200 | 2,956,000 | 0.17% | Put | |
| 47 | CITADEL ADVISORS LLC | 222,892 | 2,887,000 | 0.17% | ||
| 48 | Artal Group S.A. | 216,879 | 2,810,000 | 0.16% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 208,400 | 2,700,000 | 0.16% | ||
| 50 | SPHERA FUNDS MANAGEMENT LTD. | 194,200 | 2,516,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
