| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,759,431 | 16,204,000 | 50.85% | ||
| 2 | First Eagle Investment Management, LLC | 352,000 | 3,242,000 | 10.17% | ||
| 3 | AXA S.A. | 237,302 | 2,195,000 | 6.89% | ||
| 4 | COLUMBUS CIRCLE INVESTORS | 124,321 | 1,150,000 | 3.61% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 121,305 | 1,122,000 | 3.52% | ||
| 6 | BLACKROCK ADVISORS LLC | 117,400 | 1,086,000 | 3.41% | ||
| 7 | BVF INC/IL | 106,500 | 981,000 | 3.08% | ||
| 8 | PUTNAM INVESTMENTS LLC | 96,061 | 885,000 | 2.78% | ||
| 9 | DEUTSCHE BANK AG\ | 91,658 | 846,000 | 2.65% | ||
| 10 | SABBY MANAGEMENT, LLC | 67,313 | 620,000 | 1.95% | ||
| 11 | WALL STREET ASSOCIATES | 55,000 | 509,000 | 1.60% | ||
| 12 | FARALLON CAPITAL MANAGEMENT LLC | 50,000 | 463,000 | 1.45% | ||
| 13 | EVENTIDE ASSET MANAGEMENT, LLC | 49,100 | 452,000 | 1.42% | ||
| 14 | BlackRock Group LTD | 43,800 | 405,000 | 1.27% | ||
| 15 | DAFNA Capital Management LLC | 32,000 | 296,000 | 0.93% | SH | |
| 16 | BAKER BROS. ADVISORS LP | 30,672 | 284,000 | 0.89% | ||
| 17 | Granite Investment Partners, LLC | 27,166 | 251,000 | 0.79% | ||
| 18 | BlackRock Finance, Inc. | 24,800 | 229,000 | 0.72% | ||
| 19 | D. E. Shaw & Co., Inc. | 24,287 | 224,000 | 0.70% | ||
| 20 | SSI INVESTMENT MANAGEMENT LLC | 22,095 | 205,000 | 0.64% | ||
| 21 | Alyeska Investment Group, L.P. | 12,050 | 111,000 | 0.35% | ||
| 22 | HighTower Advisors, LLC | 10,000 | 93,000 | 0.29% | ||
| 23 | ROYAL BANK OF CANADA | 1,000 | 9,000 | 0.03% | ||
| 24 | WELLS FARGO & COMPANY/MN | 300 | 3,000 | 0.01% | ||
| 25 | CITIGROUP INC | 364 | 3,000 | 0.01% | ||
| 26 | MORGAN STANLEY | 100 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
