| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 1,342,093 | 9,891,000 | 16.44% | ||
| 2 | FMR LLC | 1,005,219 | 7,409,000 | 12.31% | ||
| 3 | Point72 Asset Management, L.P. | 562,447 | 4,145,000 | 6.89% | ||
| 4 | MORGAN STANLEY | 395,603 | 2,915,000 | 4.84% | ||
| 5 | Spark Investment Management LLC | 380,400 | 2,803,000 | 4.66% | ||
| 6 | PUTNAM INVESTMENTS LLC | 374,231 | 2,758,000 | 4.58% | ||
| 7 | Passport Capital, LLC | 371,442 | 2,738,000 | 4.55% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 347,271 | 2,559,000 | 4.25% | ||
| 9 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 332,209 | 2,448,000 | 4.07% | ||
| 10 | BlackRock Fund Advisors | 315,775 | 2,327,000 | 3.87% | ||
| 11 | Tekla Capital Management LLC | 241,021 | 1,776,000 | 2.95% | ||
| 12 | BAKER BROS. ADVISORS LP | 230,000 | 1,695,000 | 2.82% | ||
| 13 | ASCEND CAPITAL, LLC | 220,000 | 1,621,000 | 2.69% | ||
| 14 | ORBIMED ADVISORS LLC | 195,400 | 1,440,000 | 2.39% | ||
| 15 | DAFNA Capital Management LLC | 158,907 | 1,171,000 | 1.95% | SH | |
| 16 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 158,435 | 1,167,000 | 1.94% | ||
| 17 | RENAISSANCE TECHNOLOGIES LLC | 157,790 | 1,163,000 | 1.93% | ||
| 18 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 150,568 | 1,110,000 | 1.84% | ||
| 19 | BANK OF AMERICA CORP /DE/ | 145,061 | 1,069,000 | 1.78% | ||
| 20 | ACADIAN ASSET MANAGEMENT LLC | 109,033 | 804,000 | 1.34% | ||
| 21 | Granite Investment Partners, LLC | 100,448 | 740,000 | 1.23% | ||
| 22 | NEXTHERA CAPITAL LP | 93,400 | 688,000 | 1.14% | ||
| 23 | DEUTSCHE BANK AG\ | 91,683 | 674,000 | 1.12% | ||
| 24 | MACQUARIE GROUP LTD | 80,000 | 590,000 | 0.98% | ||
| 25 | Trexquant Investment LP | 79,968 | 589,000 | 0.98% | ||
| 26 | CITADEL ADVISORS LLC | 69,348 | 511,000 | 0.85% | ||
| 27 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 67,850 | 500,000 | 0.83% | ||
| 28 | VIRTUS ETF ADVISERS LLC | 26,511 | 195,000 | 0.32% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 24,139 | 178,000 | 0.30% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,000 | 177,000 | 0.29% | Put | |
| 31 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 23,675 | 175,000 | 0.29% | ||
| 32 | BlackRock Institutional Trust Company, N.A. | 23,417 | 173,000 | 0.29% | ||
| 33 | Quantitative Systematic Strategies LLC | 23,299 | 165,000 | 0.27% | ||
| 34 | Palo Alto Investors LP | 20,453 | 151,000 | 0.25% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,484 | 144,000 | 0.24% | ||
| 36 | ProShare Advisors LLC | 18,479 | 136,000 | 0.23% | ||
| 37 | CREDIT SUISSE AG/ | 17,731 | 131,000 | 0.22% | ||
| 38 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 17,298 | 127,000 | 0.21% | ||
| 39 | FOX RUN MANAGEMENT, L.L.C. | 16,600 | 122,000 | 0.20% | ||
| 40 | Princeton Alpha Management LP | 16,273 | 120,000 | 0.20% | ||
| 41 | CITIGROUP INC | 15,560 | 115,000 | 0.19% | ||
| 42 | TFS CAPITAL LLC | 15,156 | 112,000 | 0.19% | ||
| 43 | JPMORGAN CHASE & CO | 14,174 | 104,000 | 0.17% | ||
| 44 | GOLDMAN SACHS GROUP INC | 12,661 | 93,000 | 0.15% | ||
| 45 | Creative Planning | 11,995 | 88,000 | 0.15% | ||
| 46 | Compagnie Lombard Odier SCmA | 10,000 | 74,000 | 0.12% | ||
| 47 | CUTLER GROUP LLC / CA | 9,760 | 71,000 | 0.12% | ||
| 48 | Cubist Systematic Strategies, LLC | 7,376 | 54,000 | 0.09% | ||
| 49 | UBS Group AG | 4,600 | 34,000 | 0.06% | ||
| 50 | CUTLER GROUP LLC / CA | 3,200 | 25,000 | 0.04% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
