| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,271,979 | 46,462,000 | 27.23% | ||
| 2 | SECTORAL ASSET MANAGEMENT INC | 761,913 | 15,581,000 | 9.13% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 690,269 | 14,116,000 | 8.27% | ||
| 4 | Point72 Asset Management, L.P. | 555,702 | 11,364,000 | 6.66% | ||
| 5 | EverPoint Asset Management, LLC | 465,000 | 9,509,000 | 5.57% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 454,117 | 9,287,000 | 5.44% | ||
| 7 | PUTNAM INVESTMENTS LLC | 348,136 | 7,119,000 | 4.17% | ||
| 8 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 326,600 | 6,679,000 | 3.91% | ||
| 9 | Granite Investment Partners, LLC | 263,011 | 5,379,000 | 3.15% | ||
| 10 | BALYASNY ASSET MANAGEMENT L.P. | 172,292 | 3,523,000 | 2.06% | ||
| 11 | EVENTIDE ASSET MANAGEMENT, LLC | 154,900 | 3,168,000 | 1.86% | ||
| 12 | Ghost Tree Capital, LLC | 150,000 | 3,068,000 | 1.80% | ||
| 13 | J. Goldman & Co LP | 142,900 | 2,922,000 | 1.71% | Call | |
| 14 | Numeric Investors LLC | 120,508 | 2,464,000 | 1.44% | ||
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 115,000 | 2,352,000 | 1.38% | ||
| 16 | GOLDMAN SACHS GROUP INC | 102,900 | 2,104,000 | 1.23% | Call | |
| 17 | Tekla Capital Management LLC | 102,800 | 2,102,000 | 1.23% | ||
| 18 | Tekla Capital Management LLC | 102,800 | 2,102,000 | 1.23% | Call | |
| 19 | LORD, ABBETT & CO. LLC | 89,585 | 1,832,000 | 1.07% | ||
| 20 | WALL STREET ASSOCIATES | 84,600 | 1,730,000 | 1.01% | ||
| 21 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 75,550 | 1,545,000 | 0.91% | ||
| 22 | DEUTSCHE BANK AG\ | 73,145 | 1,495,000 | 0.88% | ||
| 23 | PDT Partners, LLC | 60,692 | 1,241,000 | 0.73% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,600 | 1,137,000 | 0.67% | Put | |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,797 | 1,121,000 | 0.66% | ||
| 26 | D. E. Shaw & Co., Inc. | 49,838 | 1,019,000 | 0.60% | ||
| 27 | CITADEL ADVISORS LLC | 41,237 | 843,000 | 0.49% | ||
| 28 | HARVEY CAPITAL MANAGEMENT INC | 40,465 | 827,000 | 0.48% | ||
| 29 | DAFNA Capital Management LLC | 35,000 | 716,000 | 0.42% | SH | |
| 30 | AMERIPRISE FINANCIAL INC | 32,271 | 660,000 | 0.39% | ||
| 31 | Spark Investment Management LLC | 30,500 | 623,000 | 0.37% | ||
| 32 | BAKER BROS. ADVISORS LP | 30,000 | 614,000 | 0.36% | ||
| 33 | Bank of New York Mellon Corp | 29,661 | 607,000 | 0.36% | ||
| 34 | J. Goldman & Co LP | 27,874 | 570,000 | 0.33% | ||
| 35 | DEERE & CO | 25,824 | 528,000 | 0.31% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 21,439 | 438,000 | 0.26% | ||
| 37 | Palo Alto Investors LP | 20,453 | 418,000 | 0.24% | ||
| 38 | COLUMBUS CIRCLE INVESTORS | 19,126 | 391,000 | 0.23% | ||
| 39 | CITIGROUP INC | 14,805 | 303,000 | 0.18% | ||
| 40 | MORGAN STANLEY | 14,250 | 291,000 | 0.17% | ||
| 41 | Virtu KCG Holdings LLC | 12,827 | 262,000 | 0.15% | ||
| 42 | GROUP ONE TRADING LLC | 12,135 | 248,000 | 0.15% | ||
| 43 | Weiss Multi-Strategy Advisers LLC | 12,000 | 245,000 | 0.14% | ||
| 44 | A.R.T. Advisors, LLC | 11,631 | 237,000 | 0.14% | ||
| 45 | GOLDMAN SACHS GROUP INC | 11,400 | 233,000 | 0.14% | Put | |
| 46 | Creative Planning | 11,280 | 231,000 | 0.14% | ||
| 47 | Trexquant Investment LP | 10,903 | 222,000 | 0.13% | ||
| 48 | COWEN INC. | 10,000 | 205,000 | 0.12% | ||
| 49 | GOLDMAN SACHS GROUP INC | 6,410 | 131,000 | 0.08% | ||
| 50 | Stevens First Principles Investment Advisors | 3,000 | 61,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
