| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,730,473 | 20,558,000 | 18.90% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 1,442,093 | 17,132,000 | 15.75% | ||
| 3 | SECTORAL ASSET MANAGEMENT INC | 1,427,313 | 16,956,000 | 15.59% | ||
| 4 | Passport Capital, LLC | 400,000 | 4,752,000 | 4.37% | ||
| 5 | PUTNAM INVESTMENTS LLC | 348,469 | 4,140,000 | 3.81% | ||
| 6 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 345,403 | 4,103,000 | 3.77% | ||
| 7 | Spark Investment Management LLC | 296,000 | 3,516,000 | 3.23% | ||
| 8 | BlackRock Fund Advisors | 294,118 | 3,494,000 | 3.21% | ||
| 9 | Point72 Asset Management, L.P. | 273,465 | 3,249,000 | 2.99% | ||
| 10 | Tekla Capital Management LLC | 241,021 | 2,863,000 | 2.63% | ||
| 11 | BANK OF AMERICA CORP /DE/ | 237,407 | 2,821,000 | 2.59% | ||
| 12 | BAKER BROS. ADVISORS LP | 230,000 | 2,732,000 | 2.51% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 205,800 | 2,445,000 | 2.25% | ||
| 14 | ORBIMED ADVISORS LLC | 184,800 | 2,195,000 | 2.02% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 174,900 | 2,078,000 | 1.91% | ||
| 16 | DAFNA Capital Management LLC | 158,907 | 1,888,000 | 1.74% | ||
| 17 | DEUTSCHE BANK AG\ | 157,856 | 1,874,000 | 1.72% | ||
| 18 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 154,100 | 1,831,000 | 1.68% | ||
| 19 | NEXTHERA CAPITAL LP | 115,000 | 1,366,000 | 1.26% | ||
| 20 | Granite Investment Partners, LLC | 96,279 | 1,144,000 | 1.05% | ||
| 21 | MACQUARIE GROUP LTD | 84,400 | 1,003,000 | 0.92% | ||
| 22 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 79,750 | 947,000 | 0.87% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 60,285 | 716,000 | 0.66% | ||
| 24 | CAPITAL FUND MANAGEMENT S.A. | 42,795 | 508,000 | 0.47% | ||
| 25 | DEERE & CO | 38,736 | 460,000 | 0.42% | ||
| 26 | Trexquant Investment LP | 34,254 | 407,000 | 0.37% | ||
| 27 | MORGAN STANLEY | 31,663 | 376,000 | 0.35% | ||
| 28 | Creative Planning | 24,495 | 291,000 | 0.27% | ||
| 29 | Palo Alto Investors LP | 20,453 | 243,000 | 0.22% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,300 | 241,000 | 0.22% | Put | |
| 31 | CITIGROUP INC | 17,777 | 211,000 | 0.19% | ||
| 32 | ProShare Advisors LLC | 16,813 | 200,000 | 0.18% | ||
| 33 | J. Goldman & Co LP | 15,500 | 184,000 | 0.17% | ||
| 34 | CUTLER GROUP LLC / CA | 14,860 | 176,000 | 0.16% | ||
| 35 | TFS CAPITAL LLC | 14,719 | 175,000 | 0.16% | ||
| 36 | VIRTUS ETF ADVISERS LLC | 14,182 | 168,000 | 0.15% | ||
| 37 | DekaBank Deutsche Girozentrale | 12,000 | 141,000 | 0.13% | ||
| 38 | STEVENS CAPITAL MANAGEMENT LP | 10,715 | 127,000 | 0.12% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,600 | 126,000 | 0.12% | Call | |
| 40 | CITADEL ADVISORS LLC | 10,162 | 121,000 | 0.11% | ||
| 41 | Weiss Multi-Strategy Advisers LLC | 10,000 | 119,000 | 0.11% | ||
| 42 | Compagnie Lombard Odier SCmA | 10,000 | 119,000 | 0.11% | ||
| 43 | JPMORGAN CHASE & CO | 8,414 | 100,000 | 0.09% | ||
| 44 | GROUP ONE TRADING LLC | 8,238 | 98,000 | 0.09% | ||
| 45 | CUTLER GROUP LLC / CA | 9,200 | 58,000 | 0.05% | Put | |
| 46 | Cubist Systematic Strategies, LLC | 4,644 | 55,000 | 0.05% | ||
| 47 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 3,800 | 45,000 | 0.04% | ||
| 48 | UBS Group AG | 3,149 | 37,000 | 0.03% | ||
| 49 | PRELUDE CAPITAL MANAGEMENT, LLC | 3,000 | 36,000 | 0.03% | ||
| 50 | Tower Research Capital LLC (TRC) | 2,415 | 29,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
