| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,264,124 | 37,449,000 | 26.25% | ||
| 2 | SECTORAL ASSET MANAGEMENT INC | 1,138,513 | 18,831,000 | 13.20% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 967,093 | 15,996,000 | 11.21% | ||
| 4 | Point72 Asset Management, L.P. | 465,437 | 7,698,000 | 5.40% | ||
| 5 | PUTNAM INVESTMENTS LLC | 347,372 | 5,746,000 | 4.03% | ||
| 6 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 326,600 | 5,402,000 | 3.79% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 302,913 | 5,010,000 | 3.51% | ||
| 8 | BlackRock Fund Advisors | 266,215 | 4,403,000 | 3.09% | ||
| 9 | Granite Investment Partners, LLC | 247,783 | 4,098,000 | 2.87% | ||
| 10 | Spark Investment Management LLC | 231,100 | 3,822,000 | 2.68% | ||
| 11 | Tekla Capital Management LLC | 175,500 | 2,903,000 | 2.03% | ||
| 12 | EVENTIDE ASSET MANAGEMENT, LLC | 174,900 | 2,893,000 | 2.03% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 153,500 | 2,539,000 | 1.78% | ||
| 14 | J. Goldman & Co LP | 144,600 | 2,392,000 | 1.68% | Call | |
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 142,700 | 2,360,000 | 1.65% | Call | |
| 16 | COLUMBUS CIRCLE INVESTORS | 113,548 | 1,878,000 | 1.32% | ||
| 17 | DEUTSCHE BANK AG\ | 112,088 | 1,853,000 | 1.30% | ||
| 18 | RENAISSANCE TECHNOLOGIES LLC | 105,200 | 1,740,000 | 1.22% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,200 | 1,641,000 | 1.15% | Put | |
| 20 | CQS Cayman LP | 80,000 | 1,323,000 | 0.93% | ||
| 21 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 79,750 | 1,319,000 | 0.92% | ||
| 22 | NORTHERN TRUST CORP | 53,059 | 878,000 | 0.62% | ||
| 23 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 38,357 | 634,000 | 0.44% | ||
| 24 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 38,125 | 631,000 | 0.44% | ||
| 25 | NEXTHERA CAPITAL LP | 36,000 | 595,000 | 0.42% | ||
| 26 | DAFNA Capital Management LLC | 35,000 | 579,000 | 0.41% | SH | |
| 27 | AMERIPRISE FINANCIAL INC | 32,205 | 533,000 | 0.37% | ||
| 28 | CREDIT SUISSE AG/ | 30,494 | 505,000 | 0.35% | ||
| 29 | BAKER BROS. ADVISORS LP | 30,000 | 496,000 | 0.35% | ||
| 30 | GOLDMAN SACHS GROUP INC | 29,900 | 495,000 | 0.35% | Call | |
| 31 | MORGAN STANLEY | 27,345 | 453,000 | 0.32% | ||
| 32 | DEERE & CO | 25,824 | 427,000 | 0.30% | ||
| 33 | D. E. Shaw & Co., Inc. | 24,748 | 409,000 | 0.29% | ||
| 34 | NEW YORK STATE COMMON RETIREMENT FUND | 21,439 | 355,000 | 0.25% | ||
| 35 | Creative Planning | 20,495 | 339,000 | 0.24% | ||
| 36 | Palo Alto Investors LP | 20,453 | 338,000 | 0.24% | ||
| 37 | Weiss Multi-Strategy Advisers LLC | 20,000 | 331,000 | 0.23% | ||
| 38 | Quantitative Systematic Strategies LLC | 18,850 | 304,000 | 0.21% | ||
| 39 | ProShare Advisors LLC | 18,271 | 302,000 | 0.21% | ||
| 40 | J. Goldman & Co LP | 18,011 | 298,000 | 0.21% | ||
| 41 | CITIGROUP INC | 17,911 | 296,000 | 0.21% | ||
| 42 | Bank of New York Mellon Corp | 17,111 | 283,000 | 0.20% | ||
| 43 | SABBY MANAGEMENT, LLC | 13,131 | 217,000 | 0.15% | ||
| 44 | JANE STREET GROUP, LLC | 11,600 | 192,000 | 0.13% | Call | |
| 45 | GOLDMAN SACHS GROUP INC | 11,400 | 189,000 | 0.13% | Put | |
| 46 | CAPITAL FUND MANAGEMENT S.A. | 11,200 | 185,000 | 0.13% | ||
| 47 | GROUP ONE TRADING LLC | 10,638 | 176,000 | 0.12% | ||
| 48 | NumerixS Investment Technologies Inc | 10,400 | 172,000 | 0.12% | ||
| 49 | JPMORGAN CHASE & CO | 8,164 | 135,000 | 0.09% | ||
| 50 | BANK OF AMERICA CORP /DE/ | 7,540 | 125,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
