| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,759,490 | 26,058,000 | 46.04% | ||
| 2 | First Eagle Investment Management, LLC | 352,000 | 5,213,000 | 9.21% | ||
| 3 | AXA S.A. | 253,522 | 3,755,000 | 6.63% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 195,856 | 2,901,000 | 5.13% | ||
| 5 | COLUMBUS CIRCLE INVESTORS | 182,194 | 2,698,000 | 4.77% | ||
| 6 | SPHERA FUNDS MANAGEMENT LTD. | 168,415 | 2,494,000 | 4.41% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 144,151 | 2,135,000 | 3.77% | ||
| 8 | BLACKROCK ADVISORS LLC | 117,000 | 1,732,000 | 3.06% | ||
| 9 | PUTNAM INVESTMENTS LLC | 96,061 | 1,423,000 | 2.51% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 94,101 | 1,394,000 | 2.46% | ||
| 11 | DEUTSCHE BANK AG\ | 78,958 | 1,168,000 | 2.06% | ||
| 12 | Granite Investment Partners, LLC | 65,544 | 971,000 | 1.72% | ||
| 13 | WALL STREET ASSOCIATES | 55,000 | 815,000 | 1.44% | ||
| 14 | EVENTIDE ASSET MANAGEMENT, LLC | 49,100 | 727,000 | 1.28% | ||
| 15 | BlackRock Group LTD | 43,800 | 649,000 | 1.15% | ||
| 16 | DAFNA Capital Management LLC | 39,656 | 587,000 | 1.04% | ||
| 17 | BAKER BROS. ADVISORS LP | 30,672 | 454,000 | 0.80% | ||
| 18 | BlackRock Finance, Inc. | 24,800 | 367,000 | 0.65% | ||
| 19 | MORGAN STANLEY | 21,513 | 318,000 | 0.56% | ||
| 20 | SSI INVESTMENT MANAGEMENT LLC | 18,800 | 278,000 | 0.49% | ||
| 21 | Spark Investment Management LLC | 16,700 | 247,000 | 0.44% | ||
| 22 | Alyeska Investment Group, L.P. | 11,620 | 172,000 | 0.30% | ||
| 23 | NATIONAL PLANNING CORP | 1,000 | 17,200 | 0.03% | ||
| 24 | ROYAL BANK OF CANADA | 1,000 | 15,000 | 0.03% | ||
| 25 | WELLS FARGO & COMPANY/MN | 500 | 7,000 | 0.01% | ||
| 26 | MAGEE THOMSON INVESTMENT PARTNERS LLC | 365 | 5,000 | 0.01% | ||
| 27 | Tower Research Capital LLC (TRC) | 200 | 3,000 | 0.01% | ||
| 28 | CITIGROUP INC | 5 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
