| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 592,210,000 | 22.51% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,955,248 | 307,760,000 | 11.70% | ||
| 3 | FMR LLC | 2,293,085 | 238,802,000 | 9.08% | ||
| 4 | VANGUARD GROUP INC | 1,490,694 | 155,241,000 | 5.90% | ||
| 5 | LORD, ABBETT & CO. LLC | 1,376,059 | 143,303,000 | 5.45% | ||
| 6 | CITADEL ADVISORS LLC | 1,022,316 | 106,464,000 | 4.05% | ||
| 7 | FRANKLIN RESOURCES INC | 798,805 | 83,188,000 | 3.16% | ||
| 8 | BlackRock Fund Advisors | 581,739 | 60,582,000 | 2.30% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 567,607 | 59,111,000 | 2.25% | ||
| 10 | STATE STREET CORP | 531,298 | 55,329,000 | 2.10% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 485,091 | 50,517,000 | 1.92% | ||
| 12 | FEDERATED HERMES, INC. | 470,800 | 49,029,000 | 1.86% | ||
| 13 | JENNISON ASSOCIATES LLC | 429,608 | 44,739,000 | 1.70% | ||
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 428,185 | 44,591,000 | 1.69% | ||
| 15 | JPMORGAN CHASE & CO | 423,335 | 44,085,000 | 1.68% | ||
| 16 | COLUMBUS CIRCLE INVESTORS | 359,489 | 37,437,000 | 1.42% | ||
| 17 | WELLS FARGO & COMPANY/MN | 338,082 | 35,208,000 | 1.34% | ||
| 18 | EAGLE ASSET MANAGEMENT INC | 326,639 | 34,016,000 | 1.29% | ||
| 19 | BLACKROCK ADVISORS LLC | 304,755 | 31,737,000 | 1.21% | ||
| 20 | JANUS HENDERSON INVESTORS US LLC | 301,246 | 31,372,000 | 1.19% | ||
| 21 | NORTHERN TRUST CORP | 285,360 | 29,718,000 | 1.13% | ||
| 22 | WEATHERBIE CAPITAL, LLC | 250,296 | 26,066,000 | 0.99% | ||
| 23 | Cormorant Asset Management, LP | 207,500 | 21,609,000 | 0.82% | ||
| 24 | Tekla Capital Management LLC | 185,820 | 19,351,000 | 0.74% | ||
| 25 | Redmile Group, LLC | 172,092 | 17,922,000 | 0.68% | ||
| 26 | FRED ALGER MANAGEMENT, LLC | 142,557 | 14,846,000 | 0.56% | ||
| 27 | Polar Capital LLP | 142,152 | 14,804,000 | 0.56% | ||
| 28 | TURNER INVESTMENTS LLC | 140,799 | 14,663,000 | 0.56% | ||
| 29 | Bank of New York Mellon Corp | 119,837 | 12,479,000 | 0.47% | ||
| 30 | BB BIOTECH AG | 117,991 | 12,288,000 | 0.47% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 116,901 | 12,174,000 | 0.46% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 109,085 | 11,360,000 | 0.43% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 106,900 | 11,133,000 | 0.42% | Put | |
| 34 | SAC Capital Advisors LP | 78,938 | 8,221,000 | 0.31% | ||
| 35 | BlackRock Investment Management, LLC | 64,220 | 6,688,000 | 0.25% | ||
| 36 | PUTNAM INVESTMENTS LLC | 63,488 | 6,612,000 | 0.25% | ||
| 37 | Nationwide Fund Advisors | 63,374 | 6,600,000 | 0.25% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 63,246 | 6,587,000 | 0.25% | ||
| 39 | TEACHERS ADVISORS, LLC | 62,673 | 6,527,000 | 0.25% | ||
| 40 | TD ASSET MANAGEMENT INC | 62,000 | 6,457,000 | 0.25% | ||
| 41 | GUGGENHEIM CAPITAL LLC | 59,860 | 6,234,000 | 0.24% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,600 | 5,686,000 | 0.22% | Call | |
| 43 | BANK OF AMERICA CORP /DE/ | 54,075 | 5,631,000 | 0.21% | ||
| 44 | STIFEL FINANCIAL CORP | 54,025 | 5,626,000 | 0.21% | ||
| 45 | BlackRock Group LTD | 53,346 | 5,555,000 | 0.21% | ||
| 46 | DEUTSCHE BANK AG\ | 46,104 | 4,799,000 | 0.18% | ||
| 47 | EVENTIDE ASSET MANAGEMENT, LLC | 44,900 | 4,676,000 | 0.18% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,281 | 4,403,000 | 0.17% | ||
| 49 | Tourbillon Capital Partners, L.P. | 40,000 | 4,166,000 | 0.16% | ||
| 50 | MANAGED ACCOUNT ADVISORS LLC | 39,759 | 4,141,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
