| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 1,342,679,000 | 19.27% | ||
| 2 | FMR LLC | 4,025,798 | 950,532,000 | 13.64% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,998,090 | 707,879,000 | 10.16% | ||
| 4 | Capital Research Global Investors | 2,040,740 | 481,839,000 | 6.92% | ||
| 5 | VANGUARD GROUP INC | 1,659,598 | 391,847,000 | 5.62% | ||
| 6 | FRANKLIN RESOURCES INC | 1,066,904 | 251,905,000 | 3.62% | ||
| 7 | BlackRock Fund Advisors | 649,940 | 153,457,000 | 2.20% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 585,884 | 138,334,000 | 1.99% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 568,529 | 134,235,000 | 1.93% | ||
| 10 | JANUS HENDERSON INVESTORS US LLC | 549,150 | 129,660,000 | 1.86% | ||
| 11 | BB BIOTECH AG | 521,991 | 123,247,000 | 1.77% | ||
| 12 | STATE STREET CORP | 518,268 | 122,367,000 | 1.76% | ||
| 13 | Capital International Investors | 503,700 | 118,929,000 | 1.71% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 451,053 | 106,498,000 | 1.53% | ||
| 15 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 425,579 | 100,483,458 | 1.44% | ||
| 16 | ORBIMED ADVISORS LLC | 370,200 | 87,408,000 | 1.25% | ||
| 17 | NORTHERN TRUST CORP | 262,042 | 61,871,000 | 0.89% | ||
| 18 | JPMORGAN CHASE & CO | 229,436 | 54,172,000 | 0.78% | ||
| 19 | EAGLE ASSET MANAGEMENT INC | 222,100 | 52,440,000 | 0.75% | ||
| 20 | CAPITAL GUARDIAN TRUST CO | 204,620 | 48,313,000 | 0.69% | ||
| 21 | COLUMBUS CIRCLE INVESTORS | 203,011 | 47,933,000 | 0.69% | ||
| 22 | WELLS FARGO & COMPANY/MN | 196,035 | 46,285,000 | 0.66% | ||
| 23 | NORGES BANK | 182,112 | 42,998,000 | 0.62% | ||
| 24 | ORBIS HOLDINGS LTD | 174,266 | 41,146,000 | 0.59% | ||
| 25 | BLACKROCK ADVISORS LLC | 171,589 | 40,514,000 | 0.58% | ||
| 26 | Cormorant Asset Management, LP | 167,300 | 39,501,000 | 0.57% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 165,100 | 38,982,000 | 0.56% | ||
| 28 | GOLDMAN SACHS GROUP INC | 164,852 | 38,923,000 | 0.56% | ||
| 29 | LORD, ABBETT & CO. LLC | 150,259 | 35,478,000 | 0.51% | ||
| 30 | WEATHERBIE CAPITAL, LLC | 144,721 | 34,170,000 | 0.49% | ||
| 31 | Bank of New York Mellon Corp | 134,677 | 31,799,000 | 0.46% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 134,628 | 31,787,000 | 0.46% | ||
| 33 | FEDERATED HERMES, INC. | 132,393 | 31,260,000 | 0.45% | ||
| 34 | WESTFIELD CAPITAL MANAGEMENT CO LP | 121,624 | 28,717,000 | 0.41% | ||
| 35 | UBS Group AG | 120,078 | 28,351,000 | 0.41% | ||
| 36 | DEUTSCHE BANK AG\ | 117,081 | 27,643,000 | 0.40% | ||
| 37 | Invesco Ltd. | 109,910 | 25,951,000 | 0.37% | ||
| 38 | CHARTWELL INVESTMENT PARTNERS, LLC | 107,254 | 25,324,000 | 0.36% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 105,186 | 24,835,000 | 0.36% | ||
| 40 | FRED ALGER MANAGEMENT, LLC | 94,166 | 22,233,000 | 0.32% | ||
| 41 | D. E. Shaw & Co., Inc. | 88,548 | 20,907,000 | 0.30% | ||
| 42 | OppenheimerFunds, Inc. | 87,500 | 20,660,000 | 0.30% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,100 | 20,565,000 | 0.30% | Put | |
| 44 | BANK OF AMERICA CORP /DE/ | 82,212 | 19,411,000 | 0.28% | ||
| 45 | TEACHERS ADVISORS, LLC | 81,965 | 19,353,000 | 0.28% | ||
| 46 | BlackRock Investment Management, LLC | 76,626 | 18,092,000 | 0.26% | ||
| 47 | CLOUGH CAPITAL PARTNERS L P | 75,286 | 17,776,000 | 0.26% | ||
| 48 | TD ASSET MANAGEMENT INC | 73,300 | 17,307,000 | 0.25% | ||
| 49 | TimesSquare Capital Management, LLC | 72,500 | 17,118,000 | 0.25% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 71,038 | 16,773,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
