| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 381,291,000 | 18.65% | ||
| 2 | FMR LLC | 4,873,963 | 326,799,000 | 15.98% | ||
| 3 | ORBIMED ADVISORS LLC | 2,383,525 | 159,815,000 | 7.82% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 2,287,774 | 153,395,000 | 7.50% | ||
| 5 | VANGUARD GROUP INC | 2,003,986 | 134,368,000 | 6.57% | ||
| 6 | Point72 Asset Management, L.P. | 1,028,706 | 68,975,000 | 3.37% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 931,474 | 62,455,000 | 3.05% | ||
| 8 | STATE STREET CORP | 913,183 | 61,228,000 | 2.99% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 702,894 | 47,129,000 | 2.30% | ||
| 10 | Redmile Group, LLC | 662,286 | 44,406,000 | 2.17% | ||
| 11 | AMERICAN CENTURY COMPANIES INC | 651,675 | 43,695,000 | 2.14% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 639,937 | 42,908,000 | 2.10% | ||
| 13 | BlackRock Fund Advisors | 626,024 | 41,975,000 | 2.05% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 606,615 | 40,674,000 | 1.99% | ||
| 15 | NORTHERN TRUST CORP | 275,871 | 18,497,000 | 0.90% | ||
| 16 | WEATHERBIE CAPITAL, LLC | 262,286 | 17,586,000 | 0.86% | ||
| 17 | Tekla Capital Management LLC | 260,200 | 17,446,000 | 0.85% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 249,507 | 16,729,000 | 0.82% | ||
| 19 | BB BIOTECH AG | 241,991 | 16,225,000 | 0.79% | ||
| 20 | CLOUGH CAPITAL PARTNERS L P | 233,100 | 15,629,000 | 0.76% | ||
| 21 | AMERIPRISE FINANCIAL INC | 214,192 | 14,362,000 | 0.70% | ||
| 22 | EverPoint Asset Management, LLC | 210,000 | 14,081,000 | 0.69% | ||
| 23 | NORGES BANK | 196,174 | 12,563,000 | 0.61% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 171,691 | 11,511,000 | 0.56% | ||
| 25 | Bank of New York Mellon Corp | 158,443 | 10,623,000 | 0.52% | ||
| 26 | GOLDMAN SACHS GROUP INC | 155,496 | 10,426,000 | 0.51% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 150,200 | 10,071,000 | 0.49% | Call | |
| 28 | Ghost Tree Capital, LLC | 150,000 | 10,058,000 | 0.49% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 146,800 | 9,843,000 | 0.48% | Put | |
| 30 | TEACHERS ADVISORS, LLC | 134,654 | 9,029,000 | 0.44% | ||
| 31 | Asset Management One Co., Ltd. | 135,587 | 8,959,000 | 0.44% | ||
| 32 | MORGAN STANLEY | 128,889 | 8,642,000 | 0.42% | ||
| 33 | DEUTSCHE BANK AG\ | 126,082 | 8,453,000 | 0.41% | ||
| 34 | BALYASNY ASSET MANAGEMENT L.P. | 124,028 | 8,316,000 | 0.41% | ||
| 35 | JPMORGAN CHASE & CO | 117,547 | 7,882,000 | 0.39% | ||
| 36 | UBS Group AG | 113,378 | 7,602,000 | 0.37% | ||
| 37 | BlackRock Investment Management, LLC | 92,595 | 6,208,000 | 0.30% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 91,519 | 6,137,000 | 0.30% | ||
| 39 | PAULSON & CO. INC. | 84,500 | 5,666,000 | 0.28% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 83,552 | 5,602,000 | 0.27% | ||
| 41 | JANA PARTNERS LLC | 76,074 | 5,101,000 | 0.25% | ||
| 42 | EMERALD ACQUISITION LTD. | 70,178 | 4,705,000 | 0.23% | ||
| 43 | Rock Springs Capital Management LP | 69,500 | 4,660,000 | 0.23% | ||
| 44 | Candriam S.C.A. | 68,000 | 4,559,000 | 0.22% | ||
| 45 | CREDIT SUISSE AG/ | 66,136 | 4,435,000 | 0.22% | ||
| 46 | OXFORD ASSET MANAGEMENT LLP | 63,967 | 4,289,000 | 0.21% | ||
| 47 | D. E. Shaw & Co., Inc. | 57,628 | 3,864,000 | 0.19% | ||
| 48 | WEXFORD CAPITAL LP | 57,331 | 3,844,000 | 0.19% | ||
| 49 | Informed Momentum Co LLC | 56,263 | 3,772,000 | 0.18% | ||
| 50 | BLACKROCK ADVISORS LLC | 54,120 | 3,629,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
