| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 663,918,000 | 18.28% | ||
| 2 | FMR LLC | 4,822,624 | 563,041,000 | 15.51% | ||
| 3 | Capital Research Global Investors | 2,632,312 | 307,322,000 | 8.46% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,094,447 | 244,527,000 | 6.73% | ||
| 5 | VANGUARD GROUP INC | 1,750,041 | 204,317,000 | 5.63% | ||
| 6 | Grantham, Mayo, Van Otterloo & Co. LLC | 1,426,738 | 166,572,000 | 4.59% | ||
| 7 | FRANKLIN RESOURCES INC | 1,100,076 | 128,434,000 | 3.54% | ||
| 8 | ORBIMED ADVISORS LLC | 940,800 | 109,838,000 | 3.02% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 789,824 | 92,212,000 | 2.54% | ||
| 10 | Capital International Investors | 650,034 | 75,891,000 | 2.09% | ||
| 11 | STATE STREET CORP | 621,197 | 72,523,000 | 2.00% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 588,693 | 68,730,000 | 1.89% | ||
| 13 | BB BIOTECH AG | 521,991 | 60,942,000 | 1.68% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 431,021 | 50,322,000 | 1.39% | ||
| 15 | CORNERSTONE CAPITAL MANAGEMENT LLC | 317,032 | 37,013,000 | 1.02% | ||
| 16 | JPMORGAN CHASE & CO | 295,536 | 34,505,000 | 0.95% | ||
| 17 | NORTHERN TRUST CORP | 291,844 | 34,073,000 | 0.94% | ||
| 18 | BlackRock Fund Advisors | 229,042 | 26,741,000 | 0.74% | ||
| 19 | CAPITAL GUARDIAN TRUST CO | 221,520 | 25,862,000 | 0.71% | ||
| 20 | NORGES BANK | 221,123 | 25,816,000 | 0.71% | ||
| 21 | WESTFIELD CAPITAL MANAGEMENT CO LP | 218,048 | 25,457,000 | 0.70% | ||
| 22 | GOLDMAN SACHS GROUP INC | 211,950 | 24,745,000 | 0.68% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 204,100 | 23,829,000 | 0.66% | Put | |
| 24 | BANK OF AMERICA CORP /DE/ | 160,973 | 18,793,000 | 0.52% | ||
| 25 | UBS Group AG | 159,175 | 18,583,000 | 0.51% | ||
| 26 | WEATHERBIE CAPITAL, LLC | 141,123 | 16,476,000 | 0.45% | ||
| 27 | DEUTSCHE BANK AG\ | 139,782 | 16,318,000 | 0.45% | ||
| 28 | BlackRock Group LTD | 133,939 | 15,636,000 | 0.43% | ||
| 29 | RUSSELL FRANK CO/ | 132,412 | 15,459,000 | 0.43% | ||
| 30 | CREDIT SUISSE AG/ | 131,028 | 15,297,000 | 0.42% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 126,036 | 14,702,000 | 0.40% | ||
| 32 | BLACKROCK ADVISORS LLC | 123,277 | 14,393,000 | 0.40% | ||
| 33 | WELLINGTON MANAGEMENT GROUP LLP | 121,486 | 14,184,000 | 0.39% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 121,300 | 14,162,000 | 0.39% | Call | |
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 108,135 | 12,625,000 | 0.35% | ||
| 36 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 103,110 | 12,037,000 | 0.33% | ||
| 37 | Bank of New York Mellon Corp | 102,511 | 11,968,000 | 0.33% | ||
| 38 | PERCEPTIVE ADVISORS LLC | 100,000 | 11,675,000 | 0.32% | Call | |
| 39 | GUGGENHEIM CAPITAL LLC | 92,225 | 10,767,000 | 0.30% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 91,843 | 10,723,000 | 0.30% | ||
| 41 | CAPITAL INTERNATIONAL LTD /CA/ | 90,935 | 10,617,000 | 0.29% | ||
| 42 | BARCLAYS PLC | 90,000 | 10,440,000 | 0.29% | Call | |
| 43 | WELLS FARGO & COMPANY/MN | 82,571 | 9,411,000 | 0.26% | ||
| 44 | Asset Management One Co., Ltd. | 82,165 | 9,330,000 | 0.26% | ||
| 45 | TOBAM | 79,080 | 9,233,000 | 0.25% | ||
| 46 | Sumitomo Mitsui Trust Group, Inc. | 71,303 | 8,325,000 | 0.23% | ||
| 47 | Point72 Asset Management, L.P. | 68,600 | 8,009,000 | 0.22% | ||
| 48 | COLUMBUS CIRCLE INVESTORS | 67,080 | 7,832,000 | 0.22% | ||
| 49 | TEACHERS ADVISORS, LLC | 66,861 | 7,806,000 | 0.21% | ||
| 50 | Capital International Sarl | 64,405 | 7,519,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
