| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 445,835,000 | 17.14% | ||
| 2 | FMR LLC | 4,865,362 | 381,444,000 | 14.67% | ||
| 3 | Grantham, Mayo, Van Otterloo & Co. LLC | 2,899,776 | 227,342,000 | 8.74% | ||
| 4 | ORBIMED ADVISORS LLC | 2,238,825 | 175,524,000 | 6.75% | ||
| 5 | Capital Research Global Investors | 1,826,600 | 143,205,000 | 5.51% | ||
| 6 | VANGUARD GROUP INC | 1,789,112 | 140,265,000 | 5.39% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,719,612 | 134,818,000 | 5.18% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 1,201,171 | 94,172,000 | 3.62% | ||
| 9 | Point72 Asset Management, L.P. | 945,478 | 74,125,000 | 2.85% | ||
| 10 | STATE STREET CORP | 761,829 | 59,731,000 | 2.30% | ||
| 11 | HARVARD MANAGEMENT CO INC | 600,000 | 47,040,000 | 1.81% | Call | |
| 12 | JANUS HENDERSON INVESTORS US LLC | 587,302 | 46,044,000 | 1.77% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 570,847 | 44,754,000 | 1.72% | ||
| 14 | CORNERSTONE CAPITAL MANAGEMENT LLC | 477,005 | 37,397,000 | 1.44% | ||
| 15 | BB BIOTECH AG | 431,991 | 33,868,000 | 1.30% | ||
| 16 | FRANKLIN RESOURCES INC | 294,444 | 23,084,000 | 0.89% | ||
| 17 | CITADEL ADVISORS LLC | 284,427 | 22,299,000 | 0.86% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 276,211 | 21,655,000 | 0.83% | ||
| 19 | COLUMBUS CIRCLE INVESTORS | 272,517 | 21,365,000 | 0.82% | ||
| 20 | CAPITAL GUARDIAN TRUST CO | 271,850 | 21,313,000 | 0.82% | ||
| 21 | BALYASNY ASSET MANAGEMENT L.P. | 263,286 | 20,642,000 | 0.79% | ||
| 22 | Tekla Capital Management LLC | 260,200 | 20,400,000 | 0.78% | ||
| 23 | BlackRock Fund Advisors | 242,424 | 19,006,000 | 0.73% | ||
| 24 | DEUTSCHE BANK AG\ | 239,788 | 18,798,000 | 0.72% | ||
| 25 | RUSSELL FRANK CO/ | 214,746 | 16,434,000 | 0.63% | ||
| 26 | NORGES BANK | 206,876 | 16,219,000 | 0.62% | ||
| 27 | GOLDMAN SACHS GROUP INC | 202,570 | 15,881,000 | 0.61% | ||
| 28 | D. E. Shaw & Co., Inc. | 170,670 | 13,381,000 | 0.51% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 161,600 | 12,669,000 | 0.49% | Put | |
| 30 | WEATHERBIE CAPITAL, LLC | 158,475 | 12,424,000 | 0.48% | ||
| 31 | CAPITAL INTERNATIONAL LTD /CA/ | 139,897 | 10,968,000 | 0.42% | ||
| 32 | GOLDMAN SACHS GROUP INC | 139,200 | 10,913,000 | 0.42% | Call | |
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 127,162 | 9,969,000 | 0.38% | ||
| 34 | GOLDMAN SACHS GROUP INC | 109,400 | 8,577,000 | 0.33% | Put | |
| 35 | Capital International Sarl | 108,005 | 8,468,000 | 0.33% | ||
| 36 | WELLINGTON MANAGEMENT GROUP LLP | 105,804 | 8,295,000 | 0.32% | ||
| 37 | Bank of New York Mellon Corp | 102,862 | 8,063,000 | 0.31% | ||
| 38 | UBS Group AG | 99,858 | 7,829,000 | 0.30% | ||
| 39 | MARSHALL WACE, LLP | 94,965 | 7,445,000 | 0.29% | ||
| 40 | NORTHERN TRUST CORP | 91,719 | 7,190,000 | 0.28% | ||
| 41 | Capital International, Inc./CA/ | 85,450 | 6,699,000 | 0.26% | ||
| 42 | Candriam S.C.A. | 84,300 | 6,609,000 | 0.25% | ||
| 43 | Asset Management One Co., Ltd. | 79,388 | 6,247,000 | 0.24% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 74,700 | 5,856,000 | 0.23% | Put | |
| 45 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 73,899 | 5,794,000 | 0.22% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 73,199 | 5,739,000 | 0.22% | ||
| 47 | OXFORD ASSET MANAGEMENT LLP | 73,142 | 5,713,000 | 0.22% | ||
| 48 | TEACHERS ADVISORS, LLC | 67,860 | 5,320,000 | 0.20% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 63,042 | 4,943,000 | 0.19% | ||
| 50 | JPMORGAN CHASE & CO | 62,102 | 4,869,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
