| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 167,017,000 | 18.30% | ||
| 2 | FMR LLC | 4,873,026 | 143,121,000 | 15.68% | ||
| 3 | ORBIMED ADVISORS LLC | 2,753,425 | 80,868,000 | 8.86% | ||
| 4 | Grantham, Mayo, Van Otterloo & Co. LLC | 2,010,801 | 59,057,000 | 6.47% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 1,945,510 | 57,141,000 | 6.26% | ||
| 6 | VANGUARD GROUP INC | 1,833,837 | 53,860,000 | 5.90% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,706,222 | 50,112,000 | 5.49% | ||
| 8 | Point72 Asset Management, L.P. | 1,157,700 | 34,002,000 | 3.72% | ||
| 9 | STATE STREET CORP | 1,062,291 | 31,200,000 | 3.42% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 880,525 | 25,861,000 | 2.83% | ||
| 11 | Capital Research Global Investors | 676,600 | 19,872,000 | 2.18% | ||
| 12 | CORNERSTONE CAPITAL MANAGEMENT LLC | 609,199 | 17,892,000 | 1.96% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 584,979 | 17,181,000 | 1.88% | ||
| 14 | BB BIOTECH AG | 431,991 | 12,688,000 | 1.39% | ||
| 15 | HARVARD MANAGEMENT CO INC | 300,000 | 8,811,000 | 0.97% | Call | |
| 16 | Tekla Capital Management LLC | 260,200 | 7,642,000 | 0.84% | ||
| 17 | BlackRock Fund Advisors | 230,920 | 6,782,000 | 0.74% | ||
| 18 | Visium Asset Management, LP | 215,924 | 6,342,000 | 0.69% | ||
| 19 | WEATHERBIE CAPITAL, LLC | 198,859 | 5,840,000 | 0.64% | ||
| 20 | NORGES BANK | 177,759 | 5,221,000 | 0.57% | ||
| 21 | JPMORGAN CHASE & CO | 176,530 | 5,185,000 | 0.57% | ||
| 22 | RUSSELL FRANK CO/ | 176,202 | 5,175,000 | 0.57% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 163,939 | 4,815,000 | 0.53% | ||
| 24 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 161,078 | 4,730,000 | 0.52% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 160,000 | 4,699,000 | 0.51% | Put | |
| 26 | Asset Management One Co., Ltd. | 145,868 | 4,015,000 | 0.44% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 129,935 | 3,816,000 | 0.42% | ||
| 28 | UBS Group AG | 122,209 | 3,589,000 | 0.39% | ||
| 29 | Candriam S.C.A. | 109,000 | 3,184,000 | 0.35% | ||
| 30 | Bank of New York Mellon Corp | 106,495 | 3,128,000 | 0.34% | ||
| 31 | NORTHERN TRUST CORP | 92,528 | 2,718,000 | 0.30% | ||
| 32 | GOLDMAN SACHS GROUP INC | 91,073 | 2,675,000 | 0.29% | ||
| 33 | CREDIT SUISSE AG/ | 80,380 | 2,360,000 | 0.26% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 73,808 | 2,168,000 | 0.24% | ||
| 35 | PAULSON & CO. INC. | 70,300 | 2,065,000 | 0.23% | ||
| 36 | GUGGENHEIM CAPITAL LLC | 68,932 | 2,025,000 | 0.22% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 58,500 | 1,719,000 | 0.19% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 57,300 | 1,683,000 | 0.18% | ||
| 39 | GOLDMAN SACHS GROUP INC | 57,200 | 1,680,000 | 0.18% | Call | |
| 40 | D. E. Shaw & Co., Inc. | 56,757 | 1,667,000 | 0.18% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,400 | 1,656,000 | 0.18% | Put | |
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 52,959 | 1,555,000 | 0.17% | ||
| 43 | MORGAN STANLEY | 52,213 | 1,534,000 | 0.17% | ||
| 44 | TD ASSET MANAGEMENT INC | 46,700 | 1,372,000 | 0.15% | ||
| 45 | ORBIS ALLAN GRAY LTD | 43,854 | 1,288,000 | 0.14% | ||
| 46 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 43,800 | 1,286,000 | 0.14% | ||
| 47 | Swiss National Bank | 45,130 | 1,279,000 | 0.14% | ||
| 48 | Cubist Systematic Strategies, LLC | 41,809 | 1,228,000 | 0.13% | ||
| 49 | VAN ECK ASSOCIATES CORP | 39,619 | 1,164,000 | 0.13% | ||
| 50 | ABERDEEN ASSET MANAGEMENT PLC/UK | 36,940 | 1,085,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
