| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 1,076,316,000 | 20.37% | ||
| 2 | FMR LLC | 4,035,436 | 763,787,000 | 14.46% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,766,701 | 523,653,000 | 9.91% | ||
| 4 | Capital Research Global Investors | 2,040,740 | 430,759,000 | 8.15% | ||
| 5 | VANGUARD GROUP INC | 1,523,115 | 288,280,000 | 5.46% | ||
| 6 | BlackRock Fund Advisors | 603,082 | 114,145,000 | 2.16% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 555,391 | 105,119,000 | 1.99% | ||
| 8 | BB BIOTECH AG | 521,991 | 98,797,000 | 1.87% | ||
| 9 | Capital International Investors | 503,700 | 95,335,000 | 1.80% | ||
| 10 | STATE STREET CORP | 497,090 | 94,090,000 | 1.78% | ||
| 11 | FRANKLIN RESOURCES INC | 474,185 | 89,749,000 | 1.70% | ||
| 12 | ALLIANCEBERNSTEIN L.P. | 463,566 | 87,739,000 | 1.66% | ||
| 13 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 413,856 | 78,330,525 | 1.48% | ||
| 14 | JANUS HENDERSON INVESTORS US LLC | 384,598 | 72,793,000 | 1.38% | ||
| 15 | WELLS FARGO & COMPANY/MN | 346,552 | 65,592,000 | 1.24% | ||
| 16 | NORTHERN TRUST CORP | 251,710 | 47,641,000 | 0.90% | ||
| 17 | ORBIMED ADVISORS LLC | 250,900 | 47,488,000 | 0.90% | ||
| 18 | CAPITAL GUARDIAN TRUST CO | 209,000 | 44,116,000 | 0.84% | ||
| 19 | ORBIS HOLDINGS LTD | 230,633 | 43,652,000 | 0.83% | ||
| 20 | EAGLE ASSET MANAGEMENT INC | 224,869 | 42,560,000 | 0.81% | ||
| 21 | Cormorant Asset Management, LP | 220,000 | 41,639,000 | 0.79% | ||
| 22 | BLACKROCK ADVISORS LLC | 209,825 | 39,714,000 | 0.75% | ||
| 23 | FRED ALGER MANAGEMENT, LLC | 206,698 | 39,122,000 | 0.74% | ||
| 24 | WELLINGTON MANAGEMENT GROUP LLP | 203,455 | 38,508,000 | 0.73% | ||
| 25 | COLUMBUS CIRCLE INVESTORS | 200,163 | 37,885,000 | 0.72% | ||
| 26 | JPMORGAN CHASE & CO | 190,160 | 35,991,000 | 0.68% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 178,200 | 33,728,000 | 0.64% | Put | |
| 28 | NORGES BANK | 174,901 | 33,103,000 | 0.63% | ||
| 29 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 161,300 | 30,529,000 | 0.58% | ||
| 30 | FEDERATED HERMES, INC. | 159,400 | 30,170,000 | 0.57% | ||
| 31 | WEATHERBIE CAPITAL, LLC | 124,826 | 23,626,000 | 0.45% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 123,395 | 23,354,000 | 0.44% | ||
| 33 | Bank of New York Mellon Corp | 123,217 | 23,321,000 | 0.44% | ||
| 34 | DEUTSCHE BANK AG\ | 106,441 | 20,144,000 | 0.38% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 104,263 | 19,734,000 | 0.37% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 103,900 | 19,665,000 | 0.37% | Call | |
| 37 | Redmile Group, LLC | 93,865 | 17,766,000 | 0.34% | ||
| 38 | LORD, ABBETT & CO. LLC | 84,150 | 15,927,000 | 0.30% | ||
| 39 | TimesSquare Capital Management, LLC | 82,200 | 15,558,000 | 0.29% | ||
| 40 | TEACHERS ADVISORS, LLC | 78,741 | 14,903,000 | 0.28% | ||
| 41 | LMR Partners LLP | 76,819 | 14,539,000 | 0.28% | ||
| 42 | BlackRock Investment Management, LLC | 74,794 | 14,156,000 | 0.27% | ||
| 43 | PUTNAM INVESTMENTS LLC | 71,075 | 13,453,000 | 0.25% | ||
| 44 | LOOMIS SAYLES & CO L P | 67,932 | 12,857,000 | 0.24% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 66,014 | 12,495,000 | 0.24% | ||
| 46 | Neuberger Berman Group LLC | 63,064 | 11,936,000 | 0.23% | ||
| 47 | VOYA INVESTMENT MANAGEMENT LLC | 62,100 | 11,754,000 | 0.22% | ||
| 48 | Invesco Ltd. | 60,778 | 11,503,000 | 0.22% | ||
| 49 | Allianz Asset Management GmbH | 59,644 | 11,289,000 | 0.21% | ||
| 50 | TD ASSET MANAGEMENT INC | 58,800 | 11,129,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
