| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 1,356,668,000 | 20.79% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,539,423 | 844,400,000 | 12.94% | ||
| 3 | FMR LLC | 2,789,515 | 665,494,000 | 10.20% | ||
| 4 | Capital Research Global Investors | 1,835,500 | 437,895,000 | 6.71% | ||
| 5 | VANGUARD GROUP INC | 1,501,216 | 358,146,000 | 5.49% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 553,410 | 132,027,000 | 2.02% | ||
| 7 | BlackRock Fund Advisors | 536,506 | 127,994,000 | 1.96% | ||
| 8 | WELLS FARGO & COMPANY/MN | 531,102 | 126,704,000 | 1.94% | ||
| 9 | FRANKLIN RESOURCES INC | 523,444 | 124,878,000 | 1.91% | ||
| 10 | LORD, ABBETT & CO. LLC | 511,716 | 122,080,000 | 1.87% | ||
| 11 | Cormorant Asset Management, LP | 507,500 | 121,074,000 | 1.86% | ||
| 12 | BB BIOTECH AG | 476,991 | 113,796,000 | 1.74% | ||
| 13 | STATE STREET CORP | 459,468 | 109,616,000 | 1.68% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 392,776 | 93,705,000 | 1.44% | ||
| 15 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 377,959 | 90,170,000 | 1.38% | ||
| 16 | CITADEL ADVISORS LLC | 322,989 | 77,055,000 | 1.18% | ||
| 17 | FEDERATED HERMES, INC. | 298,892 | 71,307,000 | 1.09% | ||
| 18 | JANUS HENDERSON INVESTORS US LLC | 297,425 | 70,957,000 | 1.09% | ||
| 19 | JPMORGAN CHASE & CO | 275,959 | 65,835,000 | 1.01% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 266,400 | 63,555,000 | 0.97% | Put | |
| 21 | NORTHERN TRUST CORP | 261,318 | 62,343,000 | 0.96% | ||
| 22 | BLACKROCK ADVISORS LLC | 231,246 | 55,169,000 | 0.85% | ||
| 23 | EAGLE ASSET MANAGEMENT INC | 227,470 | 54,267,000 | 0.83% | ||
| 24 | ORBIS HOLDINGS LTD | 217,262 | 51,832,000 | 0.79% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 216,800 | 51,722,000 | 0.79% | Call | |
| 26 | ORBIMED ADVISORS LLC | 212,900 | 50,792,000 | 0.78% | ||
| 27 | FRONTIER CAPITAL MANAGEMENT CO LLC | 209,630 | 50,011,000 | 0.77% | ||
| 28 | FRED ALGER MANAGEMENT, LLC | 161,904 | 38,625,000 | 0.59% | ||
| 29 | WELLINGTON MANAGEMENT GROUP LLP | 160,721 | 38,343,000 | 0.59% | ||
| 30 | NORGES BANK | 157,081 | 37,475,000 | 0.57% | ||
| 31 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 155,600 | 37,121,000 | 0.57% | ||
| 32 | Bank of New York Mellon Corp | 127,267 | 30,363,000 | 0.47% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 122,635 | 29,256,000 | 0.45% | ||
| 34 | Allianz Asset Management GmbH | 109,031 | 26,012,000 | 0.40% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 108,644 | 25,919,000 | 0.40% | ||
| 36 | Capital World Investors | 104,734 | 24,986,000 | 0.38% | ||
| 37 | WEATHERBIE CAPITAL, LLC | 101,055 | 24,109,000 | 0.37% | ||
| 38 | RS INVESTMENT MANAGEMENT CO LLC | 92,188 | 21,993,000 | 0.34% | ||
| 39 | LOOMIS SAYLES & CO L P | 87,687 | 20,919,000 | 0.32% | ||
| 40 | TimesSquare Capital Management, LLC | 86,250 | 20,577,000 | 0.32% | ||
| 41 | COLUMBUS CIRCLE INVESTORS | 84,652 | 20,195,000 | 0.31% | ||
| 42 | TEACHERS ADVISORS, LLC | 79,179 | 18,890,000 | 0.29% | ||
| 43 | BlackRock Investment Management, LLC | 76,278 | 18,198,000 | 0.28% | ||
| 44 | PUTNAM INVESTMENTS LLC | 71,118 | 16,967,000 | 0.26% | ||
| 45 | Nationwide Fund Advisors | 70,232 | 16,755,000 | 0.26% | ||
| 46 | TD ASSET MANAGEMENT INC | 70,000 | 16,700,000 | 0.26% | ||
| 47 | DEUTSCHE BANK AG\ | 66,907 | 15,960,000 | 0.24% | ||
| 48 | Neuberger Berman Group LLC | 66,664 | 15,904,000 | 0.24% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 64,677 | 15,430,000 | 0.24% | ||
| 50 | BARCLAYS PLC | 61,300 | 14,589,000 | 0.22% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
