| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 375,320,000 | 21.65% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,210,367 | 211,884,000 | 12.22% | ||
| 3 | FMR LLC | 1,518,618 | 100,229,000 | 5.78% | ||
| 4 | VANGUARD GROUP INC | 1,492,173 | 98,483,000 | 5.68% | ||
| 5 | LORD, ABBETT & CO. LLC | 1,355,006 | 89,339,000 | 5.15% | ||
| 6 | FRANKLIN RESOURCES INC | 763,034 | 50,360,000 | 2.90% | ||
| 7 | STATE STREET CORP | 651,349 | 42,987,000 | 2.48% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 596,848 | 39,392,000 | 2.27% | ||
| 9 | BB BIOTECH AG | 576,991 | 38,081,000 | 2.20% | ||
| 10 | BlackRock Fund Advisors | 529,311 | 34,935,000 | 2.01% | ||
| 11 | JANUS HENDERSON INVESTORS US LLC | 503,608 | 33,238,000 | 1.92% | ||
| 12 | EAGLE ASSET MANAGEMENT INC | 475,768 | 31,400,000 | 1.81% | ||
| 13 | JPMORGAN CHASE & CO | 467,180 | 30,834,000 | 1.78% | ||
| 14 | FEDERATED HERMES, INC. | 465,600 | 30,730,000 | 1.77% | ||
| 15 | WELLS FARGO & COMPANY/MN | 453,586 | 29,936,000 | 1.73% | ||
| 16 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 335,665 | 22,155,000 | 1.28% | ||
| 17 | Point72 Asset Management, L.P. | 327,900 | 21,641,000 | 1.25% | ||
| 18 | COLUMBUS CIRCLE INVESTORS | 318,629 | 21,030,000 | 1.21% | ||
| 19 | BLACKROCK ADVISORS LLC | 289,260 | 19,092,000 | 1.10% | ||
| 20 | CITADEL ADVISORS LLC | 279,401 | 18,440,000 | 1.06% | ||
| 21 | NORTHERN TRUST CORP | 267,151 | 17,632,000 | 1.02% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 229,900 | 15,173,000 | 0.88% | Put | |
| 23 | ALLIANCEBERNSTEIN L.P. | 224,047 | 14,787,000 | 0.85% | ||
| 24 | FRED ALGER MANAGEMENT, LLC | 223,290 | 14,737,000 | 0.85% | ||
| 25 | ORBIMED ADVISORS LLC | 218,100 | 14,395,000 | 0.83% | ||
| 26 | JENNISON ASSOCIATES LLC | 214,547 | 14,160,000 | 0.82% | ||
| 27 | WELLINGTON MANAGEMENT GROUP LLP | 210,701 | 13,906,000 | 0.80% | ||
| 28 | Cormorant Asset Management, LP | 207,500 | 13,695,000 | 0.79% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 183,700 | 12,124,000 | 0.70% | Call | |
| 30 | HealthCor Management, L.P. | 161,000 | 10,626,000 | 0.61% | ||
| 31 | WEATHERBIE CAPITAL, LLC | 156,649 | 10,339,000 | 0.60% | ||
| 32 | BARCLAYS PLC | 154,927 | 10,225,000 | 0.59% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 149,700 | 9,880,000 | 0.57% | Call | |
| 34 | NORGES BANK | 149,212 | 9,848,000 | 0.57% | ||
| 35 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 147,400 | 9,728,000 | 0.56% | ||
| 36 | Allianz Asset Management GmbH | 131,595 | 8,685,000 | 0.50% | ||
| 37 | Numeric Investors LLC | 120,200 | 7,933,000 | 0.46% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 117,265 | 7,739,000 | 0.45% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 111,238 | 7,342,000 | 0.42% | ||
| 40 | Bank of New York Mellon Corp | 107,450 | 7,092,000 | 0.41% | ||
| 41 | AQR CAPITAL MANAGEMENT LLC | 105,689 | 6,975,000 | 0.40% | ||
| 42 | ORBIMED ADVISORS LLC | 85,000 | 5,610,000 | 0.32% | Call | |
| 43 | TEACHERS ADVISORS, LLC | 84,314 | 5,565,000 | 0.32% | ||
| 44 | DEUTSCHE BANK AG\ | 78,929 | 5,208,000 | 0.30% | ||
| 45 | STIFEL FINANCIAL CORP | 78,421 | 5,175,000 | 0.30% | ||
| 46 | BARCLAYS PLC | 77,900 | 5,142,000 | 0.30% | Call | |
| 47 | BlackRock Investment Management, LLC | 77,634 | 5,124,000 | 0.30% | ||
| 48 | GOLDMAN SACHS GROUP INC | 73,600 | 4,858,000 | 0.28% | Put | |
| 49 | TURNER INVESTMENTS LLC | 73,289 | 4,837,000 | 0.28% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 67,921 | 4,483,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
