| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,686,668 | 428,527,000 | 17.58% | ||
| 2 | FMR LLC | 4,846,573 | 365,238,000 | 14.98% | ||
| 3 | VANGUARD GROUP INC | 1,774,973 | 133,762,000 | 5.49% | ||
| 4 | Capital Research Global Investors | 1,760,840 | 132,697,000 | 5.44% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,730,703 | 130,426,000 | 5.35% | ||
| 6 | Grantham, Mayo, Van Otterloo & Co. LLC | 1,676,678 | 126,354,000 | 5.18% | ||
| 7 | ORBIMED ADVISORS LLC | 1,195,500 | 90,093,000 | 3.70% | ||
| 8 | COLUMBUS CIRCLE INVESTORS | 1,000,000 | 75,360,000 | 3.09% | Call | |
| 9 | FRANKLIN RESOURCES INC | 960,999 | 72,421,000 | 2.97% | ||
| 10 | STATE STREET CORP | 692,406 | 52,192,000 | 2.14% | ||
| 11 | Capital International Investors | 650,486 | 49,021,000 | 2.01% | ||
| 12 | HARVARD MANAGEMENT CO INC | 600,000 | 45,216,000 | 1.85% | Call | |
| 13 | BlackRock Institutional Trust Company, N.A. | 590,290 | 44,484,000 | 1.82% | ||
| 14 | JANUS HENDERSON INVESTORS US LLC | 562,665 | 42,402,000 | 1.74% | ||
| 15 | Point72 Asset Management, L.P. | 554,019 | 41,751,000 | 1.71% | ||
| 16 | BB BIOTECH AG | 521,991 | 39,337,000 | 1.61% | ||
| 17 | CORNERSTONE CAPITAL MANAGEMENT LLC | 495,145 | 37,314,000 | 1.53% | ||
| 18 | DEUTSCHE BANK AG\ | 354,508 | 26,713,000 | 1.10% | ||
| 19 | TOBAM | 318,384 | 23,994,000 | 0.98% | ||
| 20 | CAPITAL GUARDIAN TRUST CO | 289,470 | 21,814,000 | 0.89% | ||
| 21 | JPMORGAN CHASE & CO | 252,382 | 19,019,000 | 0.78% | ||
| 22 | RUSSELL FRANK CO/ | 235,533 | 17,749,000 | 0.73% | ||
| 23 | BlackRock Fund Advisors | 227,353 | 17,133,000 | 0.70% | ||
| 24 | WESTFIELD CAPITAL MANAGEMENT CO LP | 221,356 | 16,681,000 | 0.68% | ||
| 25 | NORGES BANK | 206,876 | 15,590,000 | 0.64% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 186,343 | 14,043,000 | 0.58% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 174,410 | 13,143,000 | 0.54% | ||
| 28 | UBS Group AG | 165,049 | 12,438,000 | 0.51% | ||
| 29 | GOLDMAN SACHS GROUP INC | 163,200 | 12,299,000 | 0.50% | Call | |
| 30 | RENAISSANCE TECHNOLOGIES LLC | 162,600 | 12,254,000 | 0.50% | ||
| 31 | CAPITAL INTERNATIONAL LTD /CA/ | 145,697 | 10,980,000 | 0.45% | ||
| 32 | WEATHERBIE CAPITAL, LLC | 137,041 | 10,327,000 | 0.42% | ||
| 33 | NORTHERN TRUST CORP | 130,876 | 9,863,000 | 0.40% | ||
| 34 | WELLINGTON MANAGEMENT GROUP LLP | 124,640 | 9,393,000 | 0.39% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 124,500 | 9,382,000 | 0.38% | Put | |
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 121,780 | 9,170,000 | 0.38% | ||
| 37 | Bank of New York Mellon Corp | 116,662 | 8,792,000 | 0.36% | ||
| 38 | CITADEL ADVISORS LLC | 115,846 | 8,730,000 | 0.36% | ||
| 39 | Capital International Sarl | 109,405 | 8,245,000 | 0.34% | ||
| 40 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 101,151 | 7,623,000 | 0.31% | ||
| 41 | GOLDMAN SACHS GROUP INC | 97,000 | 7,310,000 | 0.30% | Put | |
| 42 | Tekla Capital Management LLC | 95,200 | 7,174,000 | 0.29% | ||
| 43 | BlackRock Group LTD | 94,644 | 7,131,000 | 0.29% | ||
| 44 | COLUMBUS CIRCLE INVESTORS | 92,632 | 6,981,000 | 0.29% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 90,439 | 6,815,000 | 0.28% | ||
| 46 | Capital International, Inc./CA/ | 85,450 | 6,440,000 | 0.26% | ||
| 47 | LMCG INVESTMENTS, LLC | 84,397 | 6,361,000 | 0.26% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 81,301 | 6,127,000 | 0.25% | ||
| 49 | Asset Management One Co., Ltd. | 83,434 | 5,964,000 | 0.24% | ||
| 50 | D. E. Shaw & Co., Inc. | 76,032 | 5,730,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
