| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 13,107,200 | 106,168,000 | 12.09% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 12,033,220 | 97,469,000 | 11.10% | ||
| 3 | VANGUARD GROUP INC | 8,664,957 | 70,186,000 | 7.99% | ||
| 4 | Point72 Asset Management, L.P. | 7,054,346 | 57,140,000 | 6.51% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 5,652,494 | 45,785,000 | 5.21% | ||
| 6 | GOLDMAN SACHS GROUP INC | 5,499,240 | 44,543,000 | 5.07% | ||
| 7 | BlackRock Fund Advisors | 4,785,281 | 38,761,000 | 4.41% | ||
| 8 | STATE STREET CORP | 3,655,437 | 29,613,000 | 3.37% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,407,376 | 27,600,000 | 3.14% | ||
| 10 | FMR LLC | 3,301,071 | 26,739,000 | 3.04% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,001,739 | 24,314,000 | 2.77% | ||
| 12 | BAKER BROS. ADVISORS LP | 2,475,515 | 20,052,000 | 2.28% | ||
| 13 | RTW INVESTMENTS, LP | 2,208,749 | 17,891,000 | 2.04% | ||
| 14 | DEUTSCHE BANK AG\ | 1,765,275 | 14,297,000 | 1.63% | ||
| 15 | WELLINGTON MANAGEMENT GROUP LLP | 1,746,227 | 14,145,000 | 1.61% | ||
| 16 | NORTHERN TRUST CORP | 1,435,252 | 11,626,000 | 1.32% | ||
| 17 | Rock Springs Capital Management LP | 1,316,000 | 10,660,000 | 1.21% | ||
| 18 | BB BIOTECH AG | 1,279,340 | 10,363,000 | 1.18% | ||
| 19 | NORGES BANK | 1,119,496 | 8,660,000 | 0.99% | ||
| 20 | Cormorant Asset Management, LP | 1,006,128 | 8,150,000 | 0.93% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 972,231 | 7,875,000 | 0.90% | ||
| 22 | TURNER INVESTMENTS LLC | 962,810 | 7,798,000 | 0.89% | ||
| 23 | PERCEPTIVE ADVISORS LLC | 929,290 | 7,527,000 | 0.86% | ||
| 24 | Tourbillon Capital Partners, L.P. | 926,326 | 7,503,000 | 0.85% | ||
| 25 | AMERICAN CENTURY COMPANIES INC | 908,673 | 7,360,000 | 0.84% | ||
| 26 | Numeric Investors LLC | 894,102 | 7,242,000 | 0.82% | ||
| 27 | AXA S.A. | 830,520 | 6,727,000 | 0.77% | ||
| 28 | OXFORD ASSET MANAGEMENT LLP | 805,967 | 6,528,000 | 0.74% | ||
| 29 | Invesco Ltd. | 799,847 | 6,479,000 | 0.74% | ||
| 30 | TEACHERS ADVISORS, LLC | 766,004 | 6,205,000 | 0.71% | ||
| 31 | South Dakota Investment Council | 670,600 | 5,432,000 | 0.62% | ||
| 32 | Connor, Clark & Lunn Investment Management Ltd. | 567,507 | 4,597,000 | 0.52% | ||
| 33 | RENAISSANCE TECHNOLOGIES LLC | 552,600 | 4,476,000 | 0.51% | ||
| 34 | Asset Management One Co., Ltd. | 527,557 | 4,183,000 | 0.48% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 514,851 | 4,170,000 | 0.47% | ||
| 36 | Bank of New York Mellon Corp | 512,591 | 4,152,000 | 0.47% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 499,828 | 4,049,000 | 0.46% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 440,860 | 3,571,000 | 0.41% | ||
| 39 | BlackRock Investment Management, LLC | 437,874 | 3,547,000 | 0.40% | ||
| 40 | VHCP MANAGEMENT II, LLC | 420,000 | 3,402,000 | 0.39% | ||
| 41 | HBK INVESTMENTS L P | 375,600 | 3,042,000 | 0.35% | ||
| 42 | MORGAN STANLEY | 363,057 | 2,940,000 | 0.33% | ||
| 43 | BLACKROCK ADVISORS LLC | 304,452 | 2,466,000 | 0.28% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 293,842 | 2,380,000 | 0.27% | ||
| 45 | CITADEL ADVISORS LLC | 292,076 | 2,366,000 | 0.27% | ||
| 46 | PDT Partners, LLC | 284,900 | 2,308,000 | 0.26% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 282,000 | 2,284,000 | 0.26% | Call | |
| 48 | QS Investors, LLC | 277,552 | 2,248,000 | 0.26% | ||
| 49 | CAPITAL FUND MANAGEMENT S.A. | 268,391 | 2,174,000 | 0.25% | ||
| 50 | Rhenman & Partners Asset Management AB | 266,000 | 2,154,600 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
