| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,091,646 | 233,299,000 | 21.54% | ||
| 2 | Third Rock Ventures, LLC | 3,895,090 | 178,473,000 | 16.48% | ||
| 3 | Flagship Ventures 2007 General Partner LLC | 1,930,369 | 88,450,000 | 8.17% | ||
| 4 | LORD, ABBETT & CO. LLC | 1,198,440 | 54,913,000 | 5.07% | ||
| 5 | Capital World Investors | 1,132,120 | 51,874,000 | 4.79% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 1,087,432 | 49,826,000 | 4.60% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,019,913 | 46,732,000 | 4.32% | ||
| 8 | VANGUARD GROUP INC | 858,689 | 39,345,000 | 3.63% | ||
| 9 | BlackRock Fund Advisors | 703,650 | 32,241,000 | 2.98% | ||
| 10 | BB BIOTECH AG | 506,000 | 23,185,000 | 2.14% | ||
| 11 | EVENTIDE ASSET MANAGEMENT, LLC | 490,500 | 22,475,000 | 2.08% | ||
| 12 | FRANKLIN RESOURCES INC | 436,500 | 20,000,000 | 1.85% | ||
| 13 | HAMILTON LANE ADVISORS LLC | 291,901 | 13,375,000 | 1.24% | ||
| 14 | Clearbridge Investments, LLC | 275,100 | 12,605,000 | 1.16% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 256,261 | 11,742,000 | 1.08% | ||
| 16 | STATE OF MICHIGAN RETIREMENT SYSTEM | 237,802 | 10,896,000 | 1.01% | ||
| 17 | JENNISON ASSOCIATES LLC | 237,239 | 10,870,000 | 1.00% | ||
| 18 | MORGAN STANLEY | 211,524 | 9,693,000 | 0.90% | ||
| 19 | BAKER BROS. ADVISORS LP | 199,893 | 9,159,000 | 0.85% | ||
| 20 | BRIDGER MANAGEMENT, LLC | 183,700 | 8,417,000 | 0.78% | ||
| 21 | Artal Group S.A. | 175,000 | 8,019,000 | 0.74% | ||
| 22 | STATE STREET CORP | 173,898 | 7,971,000 | 0.74% | ||
| 23 | FEDERATED HERMES, INC. | 172,700 | 7,913,000 | 0.73% | ||
| 24 | GENERAL ELECTRIC CO | 164,461 | 7,536,000 | 0.70% | ||
| 25 | CITADEL ADVISORS LLC | 164,074 | 7,518,000 | 0.69% | ||
| 26 | Artisan Partners Limited Partnership | 158,940 | 7,283,000 | 0.67% | ||
| 27 | BlackRock Institutional Trust Company, N.A. | 151,705 | 6,951,000 | 0.64% | ||
| 28 | BLACKROCK ADVISORS LLC | 148,557 | 6,807,000 | 0.63% | ||
| 29 | JPMORGAN CHASE & CO | 144,095 | 6,602,000 | 0.61% | ||
| 30 | QVT Financial LP | 129,100 | 5,915,000 | 0.55% | ||
| 31 | Opaleye Management Inc. | 115,000 | 5,269,000 | 0.49% | ||
| 32 | NORTHERN TRUST CORP | 99,693 | 4,568,000 | 0.42% | ||
| 33 | DEUTSCHE BANK AG\ | 91,226 | 4,179,000 | 0.39% | ||
| 34 | KORNITZER CAPITAL MANAGEMENT INC /KS | 83,300 | 3,817,000 | 0.35% | ||
| 35 | Bank of New York Mellon Corp | 78,111 | 3,579,000 | 0.33% | ||
| 36 | GUGGENHEIM CAPITAL LLC | 73,275 | 3,357,000 | 0.31% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 66,853 | 3,063,000 | 0.28% | ||
| 38 | BlackRock Finance, Inc. | 63,009 | 2,887,000 | 0.27% | ||
| 39 | AXA S.A. | 62,741 | 2,875,000 | 0.27% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 59,343 | 2,719,000 | 0.25% | ||
| 41 | MASON STREET ADVISORS, LLC | 53,710 | 2,461,000 | 0.23% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 50,807 | 2,328,000 | 0.21% | ||
| 43 | Point72 Asset Management, L.P. | 46,100 | 2,112,000 | 0.20% | ||
| 44 | BlackRock Investment Management, LLC | 45,714 | 2,095,000 | 0.19% | ||
| 45 | BlackRock Group LTD | 44,400 | 2,034,000 | 0.19% | ||
| 46 | Informed Momentum Co LLC | 41,054 | 1,881,000 | 0.17% | ||
| 47 | AMERIPRISE FINANCIAL INC | 37,408 | 1,714,000 | 0.16% | ||
| 48 | TCW GROUP INC | 35,666 | 1,634,000 | 0.15% | ||
| 49 | Spark Investment Management LLC | 31,300 | 1,433,000 | 0.13% | ||
| 50 | ALLIANCEBERNSTEIN L.P. | 31,200 | 1,430,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
