| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,616,553 | 396,472,000 | 17.71% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 4,977,114 | 351,335,000 | 15.69% | ||
| 3 | Capital World Investors | 3,031,120 | 213,967,000 | 9.56% | ||
| 4 | BB BIOTECH AG | 2,109,921 | 148,939,000 | 6.65% | ||
| 5 | Flagship Ventures 2007 General Partner LLC | 1,930,369 | 136,265,000 | 6.09% | ||
| 6 | VANGUARD GROUP INC | 1,806,818 | 127,544,000 | 5.70% | ||
| 7 | FIRST TRUST ADVISORS LP | 1,623,430 | 114,598,000 | 5.12% | ||
| 8 | Capital International Investors | 1,345,172 | 94,956,000 | 4.24% | ||
| 9 | BlackRock Fund Advisors | 766,783 | 54,127,000 | 2.42% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 611,653 | 43,177,000 | 1.93% | ||
| 11 | STATE STREET CORP | 582,347 | 41,105,000 | 1.84% | ||
| 12 | CAPITAL GUARDIAN TRUST CO | 414,790 | 29,280,000 | 1.31% | ||
| 13 | GILDER GAGNON HOWE & CO LLC | 411,653 | 29,059,000 | 1.30% | ||
| 14 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 392,133 | 27,681,000 | 1.24% | ||
| 15 | ALLIANCEBERNSTEIN L.P. | 325,434 | 22,972,000 | 1.03% | ||
| 16 | Clearbridge Investments, LLC | 314,878 | 22,227,000 | 0.99% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 253,457 | 17,892,000 | 0.80% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 244,900 | 17,287,000 | 0.77% | ||
| 19 | Apex Capital Management | 228,601 | 16,137,000 | 0.72% | ||
| 20 | Artal Group S.A. | 225,000 | 15,883,000 | 0.71% | ||
| 21 | Cannell & Co. | 218,855 | 15,449,000 | 0.69% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 204,814 | 14,458,000 | 0.65% | ||
| 23 | AMERICAN CENTURY COMPANIES INC | 174,286 | 12,303,000 | 0.55% | ||
| 24 | NORGES BANK | 169,049 | 11,934,000 | 0.53% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 163,634 | 11,550,000 | 0.52% | ||
| 26 | JENNISON ASSOCIATES LLC | 158,943 | 11,220,000 | 0.50% | ||
| 27 | CAPITAL INTERNATIONAL LTD /CA/ | 147,200 | 10,391,000 | 0.46% | ||
| 28 | MORGAN STANLEY | 140,640 | 9,928,000 | 0.44% | ||
| 29 | BALYASNY ASSET MANAGEMENT L.P. | 126,161 | 8,906,000 | 0.40% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,400 | 8,852,000 | 0.40% | Put | |
| 31 | NORTHERN TRUST CORP | 119,569 | 8,441,000 | 0.38% | ||
| 32 | SABBY MANAGEMENT, LLC | 109,521 | 7,731,000 | 0.35% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 107,200 | 7,567,000 | 0.34% | Call | |
| 34 | GUGGENHEIM CAPITAL LLC | 104,505 | 7,377,000 | 0.33% | ||
| 35 | Bank of New York Mellon Corp | 103,057 | 7,275,000 | 0.32% | ||
| 36 | CAPITAL FUND MANAGEMENT S.A. | 101,299 | 7,151,000 | 0.32% | ||
| 37 | BAKER BROS. ADVISORS LP | 100,000 | 7,059,000 | 0.32% | ||
| 38 | JANUS HENDERSON INVESTORS US LLC | 95,243 | 6,723,000 | 0.30% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 86,435 | 6,101,000 | 0.27% | ||
| 40 | Capital International Sarl | 81,300 | 5,739,000 | 0.26% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 76,880 | 5,427,000 | 0.24% | ||
| 42 | AXA S.A. | 73,379 | 5,180,000 | 0.23% | ||
| 43 | Capital International, Inc./CA/ | 72,700 | 5,132,000 | 0.23% | ||
| 44 | Artisan Partners Limited Partnership | 66,606 | 4,702,000 | 0.21% | ||
| 45 | EATON VANCE MANAGEMENT | 54,880 | 3,874,000 | 0.17% | ||
| 46 | BANK OF AMERICA CORP /DE/ | 54,601 | 3,854,000 | 0.17% | ||
| 47 | DEUTSCHE BANK AG\ | 54,150 | 3,819,000 | 0.17% | ||
| 48 | BELLEVUE ASSET MANAGEMENT AG | 54,000 | 3,812,000 | 0.17% | ||
| 49 | Jefferies Group LLC | 52,700 | 3,720,000 | 0.17% | Call | |
| 50 | Allianz Asset Management GmbH | 51,500 | 3,635,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
