| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 5,564,414 | 217,847,000 | 27.08% | ||
| 2 | Flagship Ventures 2007 General Partner LLC | 3,860,738 | 151,148,000 | 18.79% | ||
| 3 | FMR LLC | 3,640,679 | 142,533,000 | 17.72% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,109,342 | 43,431,000 | 5.40% | ||
| 5 | VANGUARD GROUP INC | 753,784 | 29,511,000 | 3.67% | ||
| 6 | BlackRock Fund Advisors | 550,126 | 21,537,000 | 2.68% | ||
| 7 | FRANKLIN RESOURCES INC | 478,300 | 18,725,000 | 2.33% | ||
| 8 | EVENTIDE ASSET MANAGEMENT, LLC | 454,200 | 17,782,000 | 2.21% | ||
| 9 | LORD, ABBETT & CO. LLC | 434,616 | 17,015,000 | 2.12% | ||
| 10 | Capital World Investors | 335,000 | 13,115,000 | 1.63% | ||
| 11 | JENNISON ASSOCIATES LLC | 309,407 | 12,113,000 | 1.51% | ||
| 12 | Clearbridge Investments, LLC | 275,100 | 10,770,000 | 1.34% | ||
| 13 | DRIEHAUS CAPITAL MANAGEMENT LLC | 266,159 | 10,420,000 | 1.30% | ||
| 14 | FEDERATED HERMES, INC. | 229,550 | 8,987,000 | 1.12% | ||
| 15 | Bain Capital Public Equity Management, LLC | 207,889 | 8,139,000 | 1.01% | ||
| 16 | MORGAN STANLEY | 201,501 | 7,890,000 | 0.98% | ||
| 17 | BAKER BROS. ADVISORS LP | 199,893 | 7,826,000 | 0.97% | ||
| 18 | JPMORGAN CHASE & CO | 156,325 | 6,120,000 | 0.76% | ||
| 19 | ORACLE INVESTMENT MANAGEMENT INC | 100,000 | 3,915,000 | 0.49% | ||
| 20 | Artal Group S.A. | 100,000 | 3,915,000 | 0.49% | ||
| 21 | KORNITZER CAPITAL MANAGEMENT INC /KS | 99,300 | 3,888,000 | 0.48% | ||
| 22 | NORTHERN TRUST CORP | 89,449 | 3,502,000 | 0.44% | ||
| 23 | STATE STREET CORP | 88,781 | 3,476,000 | 0.43% | ||
| 24 | GREEN ARROW CAPITAL MANAGEMENT LLC | 80,000 | 3,132,000 | 0.39% | ||
| 25 | BLACKROCK ADVISORS LLC | 76,456 | 2,993,000 | 0.37% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 76,247 | 2,985,000 | 0.37% | ||
| 27 | AXA S.A. | 62,741 | 2,456,000 | 0.31% | ||
| 28 | MASON STREET ADVISORS, LLC | 53,710 | 2,103,000 | 0.26% | ||
| 29 | Bank of New York Mellon Corp | 48,468 | 1,897,000 | 0.24% | ||
| 30 | PRINCIPAL FINANCIAL GROUP INC | 41,000 | 1,605,000 | 0.20% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 38,729 | 1,516,000 | 0.19% | ||
| 32 | TCW GROUP INC | 38,659 | 1,513,000 | 0.19% | ||
| 33 | WALL STREET ASSOCIATES | 37,456 | 1,466,000 | 0.18% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 34,000 | 1,331,000 | 0.17% | ||
| 35 | Informed Momentum Co LLC | 31,390 | 1,229,000 | 0.15% | ||
| 36 | ProShare Advisors LLC | 30,775 | 1,205,000 | 0.15% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 28,032 | 1,097,000 | 0.14% | ||
| 38 | AMERIPRISE FINANCIAL INC | 27,356 | 1,071,000 | 0.13% | ||
| 39 | Absolute Return Capital, LLC | 27,215 | 1,065,000 | 0.13% | ||
| 40 | Atika Capital Management LLC | 26,250 | 1,028,000 | 0.13% | ||
| 41 | WILLIAMS JONES & ASSOCIATES LLC | 25,720 | 1,007,000 | 0.13% | ||
| 42 | BlackRock Group LTD | 22,800 | 893,000 | 0.11% | ||
| 43 | CREDIT SUISSE AG/ | 22,587 | 884,000 | 0.11% | ||
| 44 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 21,290 | 834,000 | 0.10% | ||
| 45 | RUSSELL FRANK CO/ | 20,957 | 820,000 | 0.10% | ||
| 46 | BlackRock Investment Management, LLC | 19,718 | 772,000 | 0.10% | ||
| 47 | Nationwide Fund Advisors | 19,196 | 752,000 | 0.09% | ||
| 48 | ROYAL BANK OF CANADA | 16,200 | 634,000 | 0.08% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,094 | 591,000 | 0.07% | ||
| 50 | COMMONWEALTH BANK OF AUSTRALIA | 14,500 | 568,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
