| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,494,348 | 615,587,000 | 19.48% | ||
| 2 | Capital World Investors | 3,197,120 | 370,610,000 | 11.73% | ||
| 3 | Third Rock Ventures, LLC | 3,070,090 | 343,973,000 | 10.89% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 2,014,480 | 225,702,000 | 7.14% | ||
| 5 | Flagship Ventures 2007 General Partner LLC | 1,930,369 | 216,278,000 | 6.84% | ||
| 6 | BB BIOTECH AG | 1,864,921 | 208,946,000 | 6.61% | ||
| 7 | VANGUARD GROUP INC | 1,291,702 | 144,722,000 | 4.58% | ||
| 8 | Capital International Investors | 856,400 | 95,951,000 | 3.04% | ||
| 9 | BlackRock Fund Advisors | 785,222 | 87,976,000 | 2.78% | ||
| 10 | CAPITAL GUARDIAN TRUST CO | 686,575 | 79,588,000 | 2.52% | ||
| 11 | BLACKROCK ADVISORS LLC | 382,619 | 42,868,000 | 1.36% | ||
| 12 | STATE STREET CORP | 373,383 | 41,830,000 | 1.32% | ||
| 13 | LORD, ABBETT & CO. LLC | 301,517 | 33,782,000 | 1.07% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 287,122 | 32,169,000 | 1.02% | ||
| 15 | Clearbridge Investments, LLC | 276,030 | 30,926,000 | 0.98% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 258,200 | 28,929,000 | 0.92% | ||
| 17 | ALLIANCEBERNSTEIN L.P. | 252,214 | 28,258,000 | 0.89% | ||
| 18 | MORGAN STANLEY | 231,236 | 25,908,000 | 0.82% | ||
| 19 | FEDERATED HERMES, INC. | 191,700 | 21,478,000 | 0.68% | ||
| 20 | JPMORGAN CHASE & CO | 189,820 | 21,267,000 | 0.67% | ||
| 21 | DEUTSCHE BANK AG\ | 174,752 | 19,576,000 | 0.62% | ||
| 22 | NORTHERN TRUST CORP | 164,820 | 18,466,000 | 0.58% | ||
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 164,500 | 18,431,000 | 0.58% | ||
| 24 | BAKER BROS. ADVISORS LP | 163,393 | 18,307,000 | 0.58% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 158,100 | 17,714,000 | 0.56% | Put | |
| 26 | JENNISON ASSOCIATES LLC | 156,277 | 17,509,000 | 0.55% | ||
| 27 | UBS Group AG | 148,464 | 16,634,000 | 0.53% | ||
| 28 | CAPITAL INTERNATIONAL LTD /CA/ | 138,200 | 15,484,000 | 0.49% | ||
| 29 | JANUS HENDERSON INVESTORS US LLC | 131,520 | 14,736,000 | 0.47% | ||
| 30 | COLUMBUS CIRCLE INVESTORS | 122,547 | 13,730,000 | 0.43% | ||
| 31 | Opaleye Management Inc. | 113,500 | 12,717,000 | 0.40% | ||
| 32 | PRICE T ROWE ASSOCIATES INC /MD/ | 107,580 | 12,053,000 | 0.38% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 107,300 | 12,022,000 | 0.38% | Call | |
| 34 | GILDER GAGNON HOWE & CO LLC | 103,316 | 11,576,000 | 0.37% | ||
| 35 | Artisan Partners Limited Partnership | 99,573 | 11,156,000 | 0.35% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 98,747 | 11,064,000 | 0.35% | ||
| 37 | Artal Group S.A. | 90,000 | 10,084,000 | 0.32% | ||
| 38 | Capital International Sarl | 89,300 | 10,005,000 | 0.32% | ||
| 39 | BlackRock Group LTD | 87,757 | 9,832,000 | 0.31% | ||
| 40 | Bank of New York Mellon Corp | 81,037 | 9,079,000 | 0.29% | ||
| 41 | GUGGENHEIM CAPITAL LLC | 71,647 | 8,027,000 | 0.25% | ||
| 42 | GEODE CAPITAL MANAGEMENT, LLC | 70,502 | 7,899,000 | 0.25% | ||
| 43 | AXA S.A. | 66,603 | 7,462,000 | 0.24% | ||
| 44 | Capital International, Inc./CA/ | 66,600 | 7,462,000 | 0.24% | ||
| 45 | BlackRock Investment Management, LLC | 62,710 | 7,026,000 | 0.22% | ||
| 46 | QVT Financial LP | 56,048 | 6,280,000 | 0.20% | ||
| 47 | A.R.T. Advisors, LLC | 55,377 | 6,204,000 | 0.20% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 48,151 | 5,395,000 | 0.17% | ||
| 49 | Tekla Capital Management LLC | 46,200 | 5,176,000 | 0.16% | ||
| 50 | CREDIT SUISSE AG/ | 39,947 | 4,474,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
