| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,646,095 | 366,544,000 | 16.89% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 5,267,467 | 341,965,000 | 15.75% | ||
| 3 | Capital World Investors | 3,136,120 | 203,597,000 | 9.38% | ||
| 4 | BB BIOTECH AG | 2,159,921 | 140,222,000 | 6.46% | ||
| 5 | Flagship Ventures 2007 General Partner LLC | 1,930,369 | 125,320,000 | 5.77% | ||
| 6 | VANGUARD GROUP INC | 1,864,013 | 121,012,000 | 5.58% | ||
| 7 | FIRST TRUST ADVISORS LP | 1,463,946 | 95,039,000 | 4.38% | ||
| 8 | Capital International Investors | 1,347,005 | 87,448,000 | 4.03% | ||
| 9 | Clearbridge Investments, LLC | 1,315,060 | 85,374,000 | 3.93% | ||
| 10 | STATE STREET CORP | 903,194 | 58,631,000 | 2.70% | ||
| 11 | BlackRock Fund Advisors | 683,910 | 44,399,000 | 2.05% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 613,649 | 39,838,000 | 1.84% | ||
| 13 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 436,994 | 28,370,000 | 1.31% | ||
| 14 | CAPITAL GUARDIAN TRUST CO | 434,341 | 28,197,000 | 1.30% | ||
| 15 | JENNISON ASSOCIATES LLC | 430,085 | 27,921,000 | 1.29% | ||
| 16 | GILDER GAGNON HOWE & CO LLC | 367,726 | 23,873,000 | 1.10% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 300,800 | 19,528,000 | 0.90% | ||
| 18 | Artal Group S.A. | 275,000 | 17,853,000 | 0.82% | ||
| 19 | Apex Capital Management | 228,867 | 14,858,000 | 0.68% | ||
| 20 | PRICE T ROWE ASSOCIATES INC /MD/ | 220,619 | 14,323,000 | 0.66% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 197,267 | 12,807,000 | 0.59% | ||
| 22 | LORD, ABBETT & CO. LLC | 173,722 | 11,278,000 | 0.52% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 172,544 | 11,201,000 | 0.52% | ||
| 24 | CAPITAL INTERNATIONAL LTD /CA/ | 166,200 | 10,790,000 | 0.50% | ||
| 25 | NORGES BANK | 155,610 | 10,102,000 | 0.47% | ||
| 26 | MORGAN STANLEY | 139,533 | 9,058,000 | 0.42% | ||
| 27 | NORTHERN TRUST CORP | 118,294 | 7,680,000 | 0.35% | ||
| 28 | Capital International Sarl | 116,700 | 7,576,000 | 0.35% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 112,100 | 7,278,000 | 0.34% | Put | |
| 30 | Bank of New York Mellon Corp | 101,904 | 6,616,000 | 0.30% | ||
| 31 | Artal Group S.A. | 100,000 | 6,492,000 | 0.30% | Call | |
| 32 | BAKER BROS. ADVISORS LP | 100,000 | 6,492,000 | 0.30% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 98,355 | 6,385,000 | 0.29% | ||
| 34 | Capital International, Inc./CA/ | 97,900 | 6,356,000 | 0.29% | ||
| 35 | JANUS HENDERSON INVESTORS US LLC | 97,803 | 6,349,000 | 0.29% | ||
| 36 | CASDIN CAPITAL, LLC | 96,500 | 6,265,000 | 0.29% | ||
| 37 | GUGGENHEIM CAPITAL LLC | 91,300 | 5,927,000 | 0.27% | ||
| 38 | GOLDMAN SACHS GROUP INC | 90,000 | 5,843,000 | 0.27% | Call | |
| 39 | BALYASNY ASSET MANAGEMENT L.P. | 87,500 | 5,681,000 | 0.26% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 86,435 | 5,611,000 | 0.26% | ||
| 41 | AMERICAN CENTURY COMPANIES INC | 83,316 | 5,409,000 | 0.25% | ||
| 42 | UBS Group AG | 79,040 | 5,131,000 | 0.24% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 76,780 | 4,985,000 | 0.23% | ||
| 44 | AXA S.A. | 68,734 | 4,462,000 | 0.21% | ||
| 45 | Artisan Partners Limited Partnership | 65,220 | 4,234,000 | 0.20% | ||
| 46 | BANK OF AMERICA CORP /DE/ | 61,395 | 3,986,000 | 0.18% | ||
| 47 | ArrowMark Colorado Holdings LLC | 60,405 | 3,921,000 | 0.18% | ||
| 48 | EATON VANCE MANAGEMENT | 54,880 | 3,563,000 | 0.16% | ||
| 49 | BELLEVUE ASSET MANAGEMENT AG | 54,000 | 3,506,000 | 0.16% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 52,547 | 3,412,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
