| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,582,768 | 526,455,000 | 19.75% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,245,638 | 306,064,000 | 11.48% | ||
| 3 | Capital World Investors | 3,157,120 | 297,716,000 | 11.17% | ||
| 4 | Flagship Ventures 2007 General Partner LLC | 1,930,369 | 182,034,000 | 6.83% | ||
| 5 | BB BIOTECH AG | 1,849,921 | 174,448,000 | 6.54% | ||
| 6 | VANGUARD GROUP INC | 1,587,319 | 149,685,000 | 5.61% | ||
| 7 | Capital International Investors | 1,064,400 | 100,373,000 | 3.76% | ||
| 8 | BlackRock Fund Advisors | 841,219 | 79,327,000 | 2.98% | ||
| 9 | CAPITAL GUARDIAN TRUST CO | 759,256 | 71,598,000 | 2.69% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 660,232 | 62,260,000 | 2.34% | ||
| 11 | STATE STREET CORP | 446,763 | 42,131,000 | 1.58% | ||
| 12 | BLACKROCK ADVISORS LLC | 368,499 | 34,750,000 | 1.30% | ||
| 13 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 345,000 | 32,534,000 | 1.22% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 339,625 | 32,027,000 | 1.20% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 326,872 | 30,824,000 | 1.16% | ||
| 16 | JANUS HENDERSON INVESTORS US LLC | 290,205 | 27,366,000 | 1.03% | ||
| 17 | Clearbridge Investments, LLC | 275,763 | 26,004,000 | 0.98% | ||
| 18 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 201,880 | 19,037,000 | 0.71% | ||
| 19 | JPMORGAN CHASE & CO | 201,548 | 19,005,000 | 0.71% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 200,000 | 18,860,000 | 0.71% | Put | |
| 21 | MORGAN STANLEY | 187,941 | 17,724,000 | 0.66% | ||
| 22 | Apex Capital Management | 177,213 | 16,711,000 | 0.63% | ||
| 23 | NORTHERN TRUST CORP | 175,635 | 16,562,000 | 0.62% | ||
| 24 | FEDERATED HERMES, INC. | 175,000 | 16,503,000 | 0.62% | ||
| 25 | EVENTIDE ASSET MANAGEMENT, LLC | 166,200 | 15,673,000 | 0.59% | ||
| 26 | CAPITAL INTERNATIONAL LTD /CA/ | 156,900 | 14,796,000 | 0.55% | ||
| 27 | JENNISON ASSOCIATES LLC | 156,677 | 14,775,000 | 0.55% | ||
| 28 | LORD, ABBETT & CO. LLC | 156,308 | 14,740,000 | 0.55% | ||
| 29 | BAKER BROS. ADVISORS LP | 149,954 | 14,141,000 | 0.53% | ||
| 30 | Artal Group S.A. | 140,000 | 13,202,000 | 0.50% | ||
| 31 | State of Tennessee, Department of Treasury | 131,523 | 12,403,000 | 0.47% | ||
| 32 | NORGES BANK | 129,994 | 12,259,000 | 0.46% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 109,300 | 10,307,000 | 0.39% | Call | |
| 34 | Tekla Capital Management LLC | 100,300 | 9,458,000 | 0.35% | ||
| 35 | DEUTSCHE BANK AG\ | 95,698 | 9,021,000 | 0.34% | ||
| 36 | GUGGENHEIM CAPITAL LLC | 92,569 | 8,729,000 | 0.33% | ||
| 37 | BlackRock Group LTD | 91,519 | 8,630,000 | 0.32% | ||
| 38 | Bank of New York Mellon Corp | 90,847 | 8,567,000 | 0.32% | ||
| 39 | Opaleye Management Inc. | 90,000 | 8,487,000 | 0.32% | ||
| 40 | Capital International Sarl | 86,700 | 8,176,000 | 0.31% | ||
| 41 | HAMILTON LANE ADVISORS LLC | 80,439 | 7,585,000 | 0.28% | ||
| 42 | GEODE CAPITAL MANAGEMENT, LLC | 78,501 | 7,401,000 | 0.28% | ||
| 43 | Artisan Partners Limited Partnership | 74,789 | 7,053,000 | 0.26% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 72,666 | 6,852,000 | 0.26% | ||
| 45 | GILDER GAGNON HOWE & CO LLC | 72,082 | 6,797,000 | 0.25% | ||
| 46 | AXA S.A. | 71,664 | 6,758,000 | 0.25% | ||
| 47 | MILLENNIUM MANAGEMENT LLC | 69,363 | 6,541,000 | 0.25% | ||
| 48 | Capital International, Inc./CA/ | 65,100 | 6,139,000 | 0.23% | ||
| 49 | BlackRock Investment Management, LLC | 63,716 | 6,008,000 | 0.23% | ||
| 50 | Asset Management One Co., Ltd. | 58,800 | 5,809,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
