| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,211,072 | 328,069,000 | 15.89% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 5,798,331 | 306,268,000 | 14.83% | ||
| 3 | BB BIOTECH AG | 2,649,528 | 139,948,000 | 6.78% | ||
| 4 | VANGUARD GROUP INC | 2,364,221 | 124,879,000 | 6.05% | ||
| 5 | Capital International Investors | 1,504,896 | 79,489,000 | 3.85% | ||
| 6 | Clearbridge Investments, LLC | 1,458,751 | 77,051,000 | 3.73% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,239,924 | 65,493,000 | 3.17% | ||
| 8 | STATE STREET CORP | 1,090,341 | 57,594,000 | 2.79% | ||
| 9 | FLAGSHIP VENTURES MANAGEMENT, INC. | 965,369 | 50,991,000 | 2.47% | ||
| 10 | BALYASNY ASSET MANAGEMENT L.P. | 920,704 | 48,632,000 | 2.36% | ||
| 11 | BlackRock Fund Advisors | 810,238 | 42,797,000 | 2.07% | ||
| 12 | Redmile Group, LLC | 737,900 | 38,976,000 | 1.89% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 698,214 | 36,880,000 | 1.79% | ||
| 14 | Capital World Investors | 663,000 | 35,020,000 | 1.70% | ||
| 15 | FIRST TRUST ADVISORS LP | 650,332 | 34,351,000 | 1.66% | ||
| 16 | CAPITAL GUARDIAN TRUST CO | 640,200 | 33,815,000 | 1.64% | ||
| 17 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 625,627 | 33,046,000 | 1.60% | ||
| 18 | LORD, ABBETT & CO. LLC | 508,469 | 26,857,000 | 1.30% | ||
| 19 | Artal Group S.A. | 500,000 | 26,410,000 | 1.28% | Call | |
| 20 | Artal Group S.A. | 400,000 | 21,128,000 | 1.02% | ||
| 21 | BLACKROCK ADVISORS LLC | 385,747 | 20,375,000 | 0.99% | ||
| 22 | BARCLAYS PLC | 358,400 | 18,931,000 | 0.92% | Put | |
| 23 | JANUS HENDERSON INVESTORS US LLC | 338,755 | 17,893,000 | 0.87% | ||
| 24 | COLUMBUS CIRCLE INVESTORS | 302,889 | 15,999,000 | 0.77% | ||
| 25 | EVENTIDE ASSET MANAGEMENT, LLC | 300,800 | 15,888,000 | 0.77% | ||
| 26 | CITADEL ADVISORS LLC | 282,719 | 14,933,000 | 0.72% | ||
| 27 | CASDIN CAPITAL, LLC | 282,443 | 14,919,000 | 0.72% | ||
| 28 | CAPITAL INTERNATIONAL LTD /CA/ | 262,800 | 13,881,000 | 0.67% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 219,502 | 11,593,000 | 0.56% | ||
| 30 | NORGES BANK | 221,697 | 11,184,000 | 0.54% | ||
| 31 | BAKER BROS. ADVISORS LP | 207,915 | 10,982,000 | 0.53% | ||
| 32 | DEUTSCHE BANK AG\ | 203,180 | 10,728,000 | 0.52% | ||
| 33 | EcoR1 Capital, LLC | 200,000 | 10,564,000 | 0.51% | ||
| 34 | BlackRock Group LTD | 199,561 | 10,540,000 | 0.51% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 170,700 | 9,016,000 | 0.44% | Put | |
| 36 | JENNISON ASSOCIATES LLC | 169,252 | 8,940,000 | 0.43% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 165,300 | 8,731,000 | 0.42% | Call | |
| 38 | BARCLAYS PLC | 160,838 | 8,495,000 | 0.41% | ||
| 39 | NORTHERN TRUST CORP | 151,467 | 8,000,000 | 0.39% | ||
| 40 | Avoro Capital Advisors LLC | 150,000 | 7,923,000 | 0.38% | ||
| 41 | Capital International Sarl | 147,400 | 7,786,000 | 0.38% | ||
| 42 | AQR CAPITAL MANAGEMENT LLC | 133,306 | 7,041,000 | 0.34% | ||
| 43 | Opaleye Management Inc. | 130,000 | 6,867,000 | 0.33% | ||
| 44 | CREDIT SUISSE AG/ | 122,349 | 6,462,000 | 0.31% | ||
| 45 | CLARIUS GROUP, LLC | 109,230 | 5,770,000 | 0.28% | ||
| 46 | MARSHALL WACE, LLP | 107,423 | 5,675,000 | 0.27% | ||
| 47 | Bank of New York Mellon Corp | 106,824 | 5,641,000 | 0.27% | ||
| 48 | BNP Paribas Asset Management Holding S.A. | 101,707 | 5,372,000 | 0.26% | ||
| 49 | MONASHEE INVESTMENT MANAGEMENT LLC | 100,000 | 5,282,000 | 0.26% | PRN | |
| 50 | MORGAN STANLEY | 98,083 | 5,181,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
