| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,594,725 | 621,798,000 | 18.28% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 4,324,916 | 480,670,000 | 14.13% | ||
| 3 | Capital World Investors | 3,171,120 | 352,438,000 | 10.36% | ||
| 4 | BB BIOTECH AG | 1,989,921 | 221,160,000 | 6.50% | ||
| 5 | Flagship Ventures 2007 General Partner LLC | 1,930,369 | 214,541,000 | 6.31% | ||
| 6 | VANGUARD GROUP INC | 1,621,562 | 180,221,000 | 5.30% | ||
| 7 | Capital International Investors | 1,120,511 | 124,534,000 | 3.66% | ||
| 8 | FIRST TRUST ADVISORS LP | 1,079,286 | 119,952,000 | 3.53% | ||
| 9 | CAPITAL GUARDIAN TRUST CO | 725,780 | 80,663,000 | 2.37% | ||
| 10 | BlackRock Fund Advisors | 685,746 | 76,214,000 | 2.24% | ||
| 11 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 476,604 | 52,970,000 | 1.56% | ||
| 12 | STATE STREET CORP | 473,881 | 52,663,000 | 1.55% | ||
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 424,854 | 47,218,000 | 1.39% | ||
| 14 | GILDER GAGNON HOWE & CO LLC | 415,460 | 46,174,000 | 1.36% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 409,196 | 45,478,000 | 1.34% | ||
| 16 | ALLIANCEBERNSTEIN L.P. | 328,022 | 36,456,000 | 1.07% | ||
| 17 | JANUS HENDERSON INVESTORS US LLC | 300,770 | 33,428,000 | 0.98% | ||
| 18 | Clearbridge Investments, LLC | 274,862 | 30,548,000 | 0.90% | ||
| 19 | Apex Capital Management | 215,507 | 23,951,000 | 0.70% | ||
| 20 | LORD, ABBETT & CO. LLC | 211,773 | 23,536,000 | 0.69% | ||
| 21 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 207,313 | 23,040,000 | 0.68% | ||
| 22 | NORGES BANK | 202,293 | 22,482,000 | 0.66% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 196,300 | 21,817,000 | 0.64% | Put | |
| 24 | FEDERATED HERMES, INC. | 183,000 | 20,339,000 | 0.60% | ||
| 25 | AMERICAN CENTURY COMPANIES INC | 174,296 | 19,371,000 | 0.57% | ||
| 26 | MORGAN STANLEY | 166,776 | 18,536,000 | 0.54% | ||
| 27 | EVENTIDE ASSET MANAGEMENT, LLC | 166,200 | 18,471,000 | 0.54% | ||
| 28 | JPMORGAN CHASE & CO | 161,952 | 18,000,000 | 0.53% | ||
| 29 | Artal Group S.A. | 160,000 | 17,782,000 | 0.52% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 158,700 | 17,638,000 | 0.52% | Call | |
| 31 | JENNISON ASSOCIATES LLC | 157,949 | 17,554,000 | 0.52% | ||
| 32 | NORTHERN TRUST CORP | 157,030 | 17,452,000 | 0.51% | ||
| 33 | Cannell & Co. | 154,755 | 17,199,000 | 0.51% | ||
| 34 | CAPITAL INTERNATIONAL LTD /CA/ | 138,500 | 15,393,000 | 0.45% | ||
| 35 | GUGGENHEIM CAPITAL LLC | 107,968 | 12,000,000 | 0.35% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 107,306 | 11,926,000 | 0.35% | ||
| 37 | BAKER BROS. ADVISORS LP | 100,000 | 11,114,000 | 0.33% | ||
| 38 | CREDIT SUISSE AG/ | 88,093 | 9,791,000 | 0.29% | ||
| 39 | Bank of New York Mellon Corp | 79,947 | 8,886,000 | 0.26% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 78,910 | 8,770,000 | 0.26% | ||
| 41 | Capital International Sarl | 75,500 | 8,391,000 | 0.25% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 75,469 | 8,388,000 | 0.25% | ||
| 43 | AXA S.A. | 71,664 | 7,965,000 | 0.23% | ||
| 44 | Artisan Partners Limited Partnership | 65,492 | 7,279,000 | 0.21% | ||
| 45 | Capital International, Inc./CA/ | 63,800 | 7,091,000 | 0.21% | ||
| 46 | DIMENSIONAL FUND ADVISORS LP | 53,514 | 5,944,000 | 0.17% | ||
| 47 | AlpInvest Partners B.V. | 52,291 | 5,812,000 | 0.17% | ||
| 48 | DEUTSCHE BANK AG\ | 51,234 | 5,691,000 | 0.17% | ||
| 49 | MANAGED ACCOUNT ADVISORS LLC | 49,643 | 5,517,000 | 0.16% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 49,400 | 5,490,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
