| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,250,459 | 322,116,000 | 21.35% | ||
| 2 | Third Rock Ventures, LLC | 3,070,090 | 188,350,000 | 12.49% | ||
| 3 | Flagship Ventures 2007 General Partner LLC | 1,930,369 | 118,428,000 | 7.85% | ||
| 4 | BB BIOTECH AG | 1,890,521 | 115,983,000 | 7.69% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 1,663,190 | 102,037,000 | 6.76% | ||
| 6 | LORD, ABBETT & CO. LLC | 1,251,795 | 76,798,000 | 5.09% | ||
| 7 | Capital World Investors | 1,132,120 | 69,456,000 | 4.60% | ||
| 8 | VANGUARD GROUP INC | 1,079,508 | 66,227,000 | 4.39% | ||
| 9 | BlackRock Fund Advisors | 714,618 | 43,842,000 | 2.91% | ||
| 10 | STATE STREET CORP | 544,184 | 33,385,000 | 2.21% | ||
| 11 | EVENTIDE ASSET MANAGEMENT, LLC | 431,600 | 26,479,000 | 1.76% | ||
| 12 | FRANKLIN RESOURCES INC | 358,600 | 22,000,000 | 1.46% | ||
| 13 | BLACKROCK ADVISORS LLC | 290,562 | 17,826,000 | 1.18% | ||
| 14 | Clearbridge Investments, LLC | 275,100 | 16,877,000 | 1.12% | ||
| 15 | JENNISON ASSOCIATES LLC | 237,425 | 14,566,000 | 0.97% | ||
| 16 | BRIDGER MANAGEMENT, LLC | 220,099 | 13,503,000 | 0.90% | ||
| 17 | MORGAN STANLEY | 210,309 | 12,903,000 | 0.86% | ||
| 18 | Artal Group S.A. | 190,000 | 11,657,000 | 0.77% | ||
| 19 | DRIEHAUS CAPITAL MANAGEMENT LLC | 171,607 | 10,528,000 | 0.70% | ||
| 20 | BAKER BROS. ADVISORS LP | 169,893 | 10,423,000 | 0.69% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 160,200 | 9,828,000 | 0.65% | Put | |
| 22 | FEDERATED HERMES, INC. | 154,000 | 9,448,000 | 0.63% | ||
| 23 | Artisan Partners Limited Partnership | 150,996 | 9,264,000 | 0.61% | ||
| 24 | NORTHERN TRUST CORP | 145,784 | 8,944,000 | 0.59% | ||
| 25 | JPMORGAN CHASE & CO | 142,970 | 8,771,000 | 0.58% | ||
| 26 | CITADEL ADVISORS LLC | 142,452 | 8,739,000 | 0.58% | ||
| 27 | BlackRock Institutional Trust Company, N.A. | 140,456 | 8,617,000 | 0.57% | ||
| 28 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 137,800 | 8,454,000 | 0.56% | ||
| 29 | QVT Financial LP | 136,100 | 8,350,000 | 0.55% | ||
| 30 | Opaleye Management Inc. | 113,500 | 6,963,225 | 0.46% | ||
| 31 | PFM Health Sciences, LP | 108,241 | 6,641,000 | 0.44% | ||
| 32 | DEUTSCHE BANK AG\ | 100,065 | 6,137,000 | 0.41% | ||
| 33 | Cormorant Asset Management, LP | 100,000 | 6,135,000 | 0.41% | ||
| 34 | COLUMBUS CIRCLE INVESTORS | 80,314 | 4,927,000 | 0.33% | ||
| 35 | Bank of New York Mellon Corp | 78,227 | 4,799,000 | 0.32% | ||
| 36 | GREEN ARROW CAPITAL MANAGEMENT LLC | 75,000 | 4,601,000 | 0.31% | ||
| 37 | GUGGENHEIM CAPITAL LLC | 74,002 | 4,540,000 | 0.30% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,500 | 4,325,000 | 0.29% | Call | |
| 39 | BlackRock Group LTD | 66,038 | 4,052,000 | 0.27% | ||
| 40 | AXA S.A. | 62,341 | 3,825,000 | 0.25% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 61,400 | 3,766,000 | 0.25% | ||
| 42 | BlackRock Investment Management, LLC | 54,939 | 3,371,000 | 0.22% | ||
| 43 | Atika Capital Management LLC | 54,000 | 3,313,000 | 0.22% | ||
| 44 | MASON STREET ADVISORS, LLC | 53,710 | 3,295,000 | 0.22% | ||
| 45 | CREDIT SUISSE AG/ | 53,354 | 3,273,000 | 0.22% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 49,735 | 3,051,000 | 0.20% | ||
| 47 | Redmile Group, LLC | 49,200 | 3,018,000 | 0.20% | ||
| 48 | Zweig-DiMenna Associates LLC | 46,483 | 2,852,000 | 0.19% | ||
| 49 | HELLMAN JORDAN MANAGEMENT CO INC /MA/ | 40,000 | 2,454,000 | 0.16% | ||
| 50 | WILLIAMS JONES & ASSOCIATES LLC | 37,675 | 2,311,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
