| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,684,768 | 238,163,000 | 16.56% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 5,309,050 | 222,423,000 | 15.47% | ||
| 3 | BB BIOTECH AG | 2,363,321 | 99,011,000 | 6.89% | ||
| 4 | VANGUARD GROUP INC | 2,105,591 | 88,214,000 | 6.14% | ||
| 5 | Capital World Investors | 2,076,491 | 86,995,000 | 6.05% | ||
| 6 | Flagship Ventures 2007 General Partner LLC | 1,930,369 | 80,873,000 | 5.62% | ||
| 7 | Capital International Investors | 1,501,037 | 62,886,000 | 4.37% | ||
| 8 | Clearbridge Investments, LLC | 1,460,275 | 61,178,000 | 4.26% | ||
| 9 | STATE STREET CORP | 899,186 | 37,672,000 | 2.62% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 831,949 | 34,855,000 | 2.42% | ||
| 11 | BlackRock Fund Advisors | 764,585 | 32,032,000 | 2.23% | ||
| 12 | CAPITAL GUARDIAN TRUST CO | 668,100 | 27,990,000 | 1.95% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 641,781 | 26,887,000 | 1.87% | ||
| 14 | FIRST TRUST ADVISORS LP | 591,071 | 24,763,000 | 1.72% | ||
| 15 | LORD, ABBETT & CO. LLC | 411,920 | 17,257,000 | 1.20% | ||
| 16 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 399,236 | 16,726,000 | 1.16% | ||
| 17 | Artal Group S.A. | 375,000 | 15,711,000 | 1.09% | ||
| 18 | BALYASNY ASSET MANAGEMENT L.P. | 325,570 | 13,640,000 | 0.95% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 300,800 | 12,602,000 | 0.88% | ||
| 20 | CAPITAL INTERNATIONAL LTD /CA/ | 260,600 | 10,918,000 | 0.76% | ||
| 21 | BLACKROCK ADVISORS LLC | 253,023 | 10,600,000 | 0.74% | ||
| 22 | DEUTSCHE BANK AG\ | 238,135 | 9,975,000 | 0.69% | ||
| 23 | Fiera Capital Corp | 231,687 | 9,707,000 | 0.68% | ||
| 24 | NORGES BANK | 221,697 | 9,288,000 | 0.65% | ||
| 25 | BAKER BROS. ADVISORS LP | 207,915 | 8,711,000 | 0.61% | ||
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 199,602 | 8,362,000 | 0.58% | ||
| 27 | CASDIN CAPITAL, LLC | 187,500 | 7,855,000 | 0.55% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 184,770 | 7,740,000 | 0.54% | ||
| 29 | JENNISON ASSOCIATES LLC | 169,974 | 7,121,000 | 0.50% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,800 | 6,402,000 | 0.45% | Put | |
| 31 | Capital International Sarl | 147,400 | 6,175,000 | 0.43% | ||
| 32 | BlackRock Group LTD | 131,126 | 5,493,000 | 0.38% | ||
| 33 | NORTHERN TRUST CORP | 124,316 | 5,208,000 | 0.36% | ||
| 34 | Bank of New York Mellon Corp | 108,966 | 4,564,000 | 0.32% | ||
| 35 | MORGAN STANLEY | 106,904 | 4,479,000 | 0.31% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 101,901 | 4,269,000 | 0.30% | ||
| 37 | CREDIT SUISSE AG/ | 99,887 | 4,184,000 | 0.29% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 93,435 | 3,914,000 | 0.27% | ||
| 39 | ArrowMark Colorado Holdings LLC | 85,405 | 3,578,000 | 0.25% | ||
| 40 | Opaleye Management Inc. | 85,000 | 3,561,000 | 0.25% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 80,776 | 3,384,000 | 0.24% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 77,700 | 3,255,000 | 0.23% | Call | |
| 43 | Capital International, Inc./CA/ | 65,100 | 2,727,000 | 0.19% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 65,039 | 2,725,000 | 0.19% | ||
| 45 | AXA S.A. | 64,967 | 2,722,000 | 0.19% | ||
| 46 | BANK OF AMERICA CORP /DE/ | 64,452 | 2,700,000 | 0.19% | ||
| 47 | Artisan Partners Limited Partnership | 61,682 | 2,584,000 | 0.18% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 59,941 | 2,511,000 | 0.17% | ||
| 49 | Jefferies Group LLC | 57,800 | 2,422,000 | 0.17% | Call | |
| 50 | EATON VANCE MANAGEMENT | 54,880 | 2,299,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
