| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORACLE INVESTMENT MANAGEMENT INC | 5,691,572 | 12,294,000 | 14.19% | ||
| 2 | OppenheimerFunds, Inc. | 5,318,970 | 11,489,000 | 13.26% | ||
| 3 | Broadfin Capital, LLC | 4,675,216 | 10,098,000 | 11.65% | ||
| 4 | CLEARBRIDGE, LLC | 2,681,821 | 5,793,000 | 6.69% | ||
| 5 | BlackRock Fund Advisors | 2,257,164 | 4,875,000 | 5.63% | ||
| 6 | FMR LLC | 2,042,925 | 4,413,000 | 5.09% | ||
| 7 | TAMARACK ADVISERS, LP | 1,800,000 | 3,888,000 | 4.49% | ||
| 8 | Opaleye Management Inc. | 1,760,000 | 3,802,000 | 4.39% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 1,418,824 | 3,065,000 | 3.54% | ||
| 10 | BALYASNY ASSET MANAGEMENT L.P. | 1,250,000 | 2,700,000 | 3.12% | ||
| 11 | AMERIPRISE FINANCIAL INC | 1,187,983 | 2,567,000 | 2.96% | ||
| 12 | PURA VIDA INVESTMENTS, LLC | 1,087,500 | 2,349,000 | 2.71% | ||
| 13 | D. E. Shaw & Co., Inc. | 1,035,625 | 2,237,000 | 2.58% | ||
| 14 | BAKER BROS. ADVISORS LP | 801,860 | 1,732,000 | 2.00% | ||
| 15 | UBS Group AG | 672,094 | 1,452,000 | 1.68% | ||
| 16 | GOLDMAN SACHS GROUP INC | 600,000 | 1,296,000 | 1.50% | Call | |
| 17 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 470,500 | 1,016,000 | 1.17% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 466,300 | 1,007,000 | 1.16% | Put | |
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 426,600 | 921,000 | 1.06% | Call | |
| 20 | J. Goldman & Co LP | 420,000 | 907,000 | 1.05% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 408,400 | 882,000 | 1.02% | ||
| 22 | GOLDMAN SACHS GROUP INC | 366,258 | 791,000 | 0.91% | ||
| 23 | ORBIMED ADVISORS LLC | 350,000 | 756,000 | 0.87% | ||
| 24 | State of New Jersey Common Pension Fund D | 187,000 | 404,000 | 0.47% | ||
| 25 | GSA CAPITAL PARTNERS LLP | 165,100 | 357,000 | 0.41% | ||
| 26 | Raymond James Financial Services Advisors, Inc. | 150,500 | 325,000 | 0.38% | ||
| 27 | MORGAN STANLEY | 138,248 | 298,000 | 0.34% | ||
| 28 | ProShare Advisors LLC | 132,338 | 286,000 | 0.33% | ||
| 29 | LPL Financial LLC | 132,514 | 284,000 | 0.33% | ||
| 30 | A.R.T. Advisors, LLC | 126,962 | 274,000 | 0.32% | ||
| 31 | GOLDMAN SACHS GROUP INC | 120,000 | 259,000 | 0.30% | Put | |
| 32 | Mariner, LLC | 104,942 | 227,000 | 0.26% | ||
| 33 | STATE STREET CORP | 104,259 | 225,000 | 0.26% | ||
| 34 | Jefferies Group LLC | 100,000 | 216,000 | 0.25% | Put | |
| 35 | CARL DOMINO INC | 98,000 | 212,000 | 0.24% | ||
| 36 | ACADIAN ASSET MANAGEMENT LLC | 97,469 | 210,000 | 0.24% | ||
| 37 | J.P. Morgan Private Wealth Advisors LLC | 86,500 | 187,000 | 0.22% | ||
| 38 | BARCLAYS PLC | 84,100 | 182,000 | 0.21% | Call | |
| 39 | BANK OF AMERICA CORP /DE/ | 82,669 | 178,000 | 0.21% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 79,241 | 171,000 | 0.20% | ||
| 41 | Virtu KCG Holdings LLC | 73,026 | 158,000 | 0.18% | ||
| 42 | CITADEL ADVISORS LLC | 73,036 | 158,000 | 0.18% | ||
| 43 | Jefferies Group LLC | 70,000 | 151,000 | 0.17% | ||
| 44 | DEUTSCHE BANK AG\ | 67,767 | 146,000 | 0.17% | ||
| 45 | BARCLAYS PLC | 57,300 | 123,000 | 0.14% | Put | |
| 46 | Timber Hill LLC | 53,504 | 116,000 | 0.13% | ||
| 47 | RAYMOND JAMES & ASSOCIATES | 39,240 | 85,000 | 0.10% | ||
| 48 | Private Advisor Group, LLC | 36,786 | 79,000 | 0.09% | ||
| 49 | Creative Planning | 31,325 | 68,000 | 0.08% | ||
| 50 | NORTHERN TRUST CORP | 30,836 | 67,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
