| # | % | |||||
|---|---|---|---|---|---|---|
| 51 | IONIS PHARMACEUTICALS INC | 2,171 | 7,955,000 | 0.30% | Call | |
| 52 | CLOVIS ONCOLOGY INC | 2,091 | 7,538,000 | 0.28% | Put | |
| 53 | ABBVIE INC | 1,178 | 7,430,000 | 0.28% | Put | |
| 54 | HORIZON PHARMA PLC | 4,088 | 7,412,000 | 0.28% | Call | |
| 55 | ACHILLION PHARMACEUTICALS INC | 9,039 | 7,322,000 | 0.27% | Call | |
| 56 | CEMPRA INC | 3,019 | 7,306,000 | 0.27% | Call | |
| 57 | TENET HEALTHCARE CORP | 3,179 | 7,204,000 | 0.27% | Call | |
| 58 | Amicus Therapeutics Inc | 9,632 | 7,128,000 | 0.27% | Call | |
| 59 | DEXCOM INC | 806 | 7,065,000 | 0.26% | Call | |
| 60 | OPHTHOTECH CORP | 1,517 | 6,998,000 | 0.26% | Call | |
| 61 | EXELIXIS INC | 5,392 | 6,896,000 | 0.26% | Put | |
| 62 | KITE PHARMA INC | 1,177 | 6,575,000 | 0.25% | Put | |
| 63 | Axovant Sciences Ltd | 4,680 | 6,552,000 | 0.25% | Call | |
| 64 | LION BIOTECHNOLOGIES INC | 7,901 | 6,503,000 | 0.24% | Put | |
| 65 | NEUROCRINE BIOSCIENCES INC | 1,214 | 6,148,000 | 0.23% | Call | |
| 66 | GILEAD SCIENCES INC | 771 | 6,100,000 | 0.23% | Put | |
| 67 | KITE PHARMA INC | 1,082 | 6,044,000 | 0.23% | Call | |
| 68 | SHIRE PLC | 31,172 | 6,043,000 | 0.23% | ||
| 69 | HALOZYME THERAPEUTICS INC | 4,901 | 5,920,000 | 0.22% | Call | |
| 70 | ALNYLAM PHARMACEUTICALS INC | 869 | 5,890,000 | 0.22% | Put | |
| 71 | PTC THERAPEUTICS INC | 3,989 | 5,589,000 | 0.21% | Call | |
| 72 | TENAX THERAPEUTICS INC COM | 2,412,857 | 5,550,000 | 0.21% | ||
| 73 | DYNAVAX TECHNOLOGIES CORP | 521,875 | 5,474,000 | 0.21% | ||
| 74 | SAGE THERAPEUTICS INC | 1,165 | 5,365,000 | 0.20% | Call | |
| 75 | HUMANA INC | 278 | 4,918,000 | 0.18% | Call | |
| 76 | LA JOLLA PHARMACEUTICAL CO | 2,064 | 4,910,000 | 0.18% | Call | |
| 77 | ABBOTT LABS | 112,888 | 4,774,000 | 0.18% | ||
| 78 | AERIE PHARMACEUTICALS INC | 1,180 | 4,453,000 | 0.17% | Call | |
| 79 | CYTRX CORP | 7,424,786 | 4,368,000 | 0.16% | ||
| 80 | SYNERGY PHARMACEUTICALS INC | 7,912 | 4,360,000 | 0.16% | Call | |
| 81 | AMARIN CORPORATION PLC | 13,648 | 4,354,000 | 0.16% | Call | |
| 82 | MEDICINES CO | 1,150 | 4,340,000 | 0.16% | Call | |
| 83 | NewLink Genetics Corp | 2,887 | 4,336,000 | 0.16% | Call | |
| 84 | PUMA BIOTECHNOLOGY INC | 643 | 4,311,000 | 0.16% | Put | |
| 85 | ACORDA THERAPEUTICS INC | 5,100,000 | 4,160,000 | 0.16% | PRN | |
| 86 | TENET HEALTHCARE CORP | 1,744 | 3,952,000 | 0.15% | Put | |
| 87 | CELGENE CORP | 37,728 | 3,944,000 | 0.15% | ||
| 88 | MANNKIND CORP | 62,303 | 3,863,000 | 0.14% | Put | |
| 89 | REGENXBIO INC COM | 263,177 | 3,687,000 | 0.14% | ||
| 90 | REGULUS THERAPEUTICS INC | 11,000 | 3,630,000 | 0.14% | Call | |
| 91 | GW PHARMACEUTICALS PLC | 273 | 3,624,000 | 0.14% | Call | |
| 92 | CYTORI THERAPEUTICS INC | 1,762,846 | 3,579,000 | 0.13% | ||
| 93 | NOVO-NORDISK A S | 859 | 3,573,000 | 0.13% | Put | |
| 94 | OpGen Inc | 2,161,467 | 3,545,000 | 0.13% | ||
| 95 | TESARO INC | 333 | 3,338,000 | 0.13% | Call | |
| 96 | UNITED THERAPEUTICS | 28,112 | 3,319,000 | 0.12% | ||
| 97 | ZOGENIX INC | 1,228 | 3,265,000 | 0.12% | Call | |
| 98 | BIOGEN INC | 100 | 3,130,000 | 0.12% | Put | |
| 99 | EIGER BIOPHARMACEUTICALS INC | 230,803 | 3,090,000 | 0.12% | ||
| 100 | ARBUTUS BIOPHARMA | 878,531 | 3,022,000 | 0.11% |
Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-16-133740, filed 2016.11.14).
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
