| # | % | |||||
|---|---|---|---|---|---|---|
| 101 | INTEC PHARMA LTD JERUSALEM | 498,006 | 2,898,000 | 0.11% | ||
| 102 | LA JOLLA PHARMACEUTICAL CO | 120,964 | 2,878,000 | 0.11% | ||
| 103 | Pieris Pharmaceuticals | 1,543,307 | 2,824,000 | 0.11% | ||
| 104 | TESARO INCORPORATED | 27,500 | 2,757,000 | 0.10% | ||
| 105 | IONIS PHARMACEUTICALS INC | 737 | 2,700,000 | 0.10% | Put | |
| 106 | OPKO HEALTH INC | 2,491 | 2,638,000 | 0.10% | Call | |
| 107 | SANGAMO THERAPEUTICS INC | 5,611 | 2,598,000 | 0.10% | Call | |
| 108 | TENET HEALTHCARE CORP | 112,831 | 2,557,000 | 0.10% | ||
| 109 | GW PHARMACEUTICALS PLC | 192 | 2,548,000 | 0.10% | Put | |
| 110 | REGENERON PHARMACEUTICALS | 63 | 2,533,000 | 0.09% | Call | |
| 111 | DURECT CORP | 1,800,000 | 2,502,000 | 0.09% | ||
| 112 | EXELIXIS INC | 1,930 | 2,468,000 | 0.09% | Call | |
| 113 | DERMIRA INC | 722 | 2,442,000 | 0.09% | Call | |
| 114 | HCA HOLDINGS INC | 316 | 2,390,000 | 0.09% | Put | |
| 115 | SOPHIRIS BIO INC | 757,033 | 2,354,000 | 0.09% | ||
| 116 | ABBOTT LABS | 555 | 2,347,000 | 0.09% | Call | |
| 117 | DERMIRA INC | 678 | 2,293,000 | 0.09% | Put | |
| 118 | PARATEK PHARMACEUTICALS INC | 175,000 | 2,277,000 | 0.09% | ||
| 119 | VERTEX PHARMACEUTICALS INC | 260 | 2,267,000 | 0.08% | Put | |
| 120 | BARCLAYS BK PLC | 65,000 | 2,215,000 | 0.08% | ||
| 121 | ENDO INTL PLC | 1,096 | 2,208,000 | 0.08% | Put | |
| 122 | CIDARA THERAPEUTICS INC | 190,358 | 2,180,000 | 0.08% | ||
| 123 | Nivalis Therapeutics Inc | 267,650 | 2,176,000 | 0.08% | ||
| 124 | OPKO HEALTH INC | 2,027 | 2,147,000 | 0.08% | Put | |
| 125 | VERSARTIS INC | 174,968 | 2,143,000 | 0.08% | ||
| 126 | EXACT SCIENCES CORP | 1,153 | 2,137,000 | 0.08% | Put | |
| 127 | INSMED INC | 1,459 | 2,118,000 | 0.08% | Call | |
| 128 | SYNERGY PHARMACEUTICALS DEL | 3,842 | 2,117,000 | 0.08% | Put | |
| 129 | FORWARD PHARMA A/S | 99,053 | 2,080,000 | 0.08% | ||
| 130 | VANDA PHARMACEUTICALS INC | 1,247 | 2,075,000 | 0.08% | Call | |
| 131 | LION BIOTECHNOLOGIES INC COM | 246,342 | 2,027,000 | 0.08% | ||
| 132 | REXAHN PHARMACEUTICALS INC | 9,464,849 | 1,988,000 | 0.07% | ||
| 133 | PROTHENA CORPORATION PLC | 325 | 1,949,000 | 0.07% | Call | |
| 134 | ACTINIUM PHARMACEUTICALS INC | 1,382,629 | 1,867,000 | 0.07% | ||
| 135 | FOAMIX PHARMACEUTICALS LTD | 201,564 | 1,866,000 | 0.07% | ||
| 136 | BIODELIVERY SCIENCES INTL IN | 689,900 | 1,863,000 | 0.07% | ||
| 137 | BIO PATH HOLDINGS INC | 1,314,692 | 1,841,000 | 0.07% | ||
| 138 | EDITAS MEDICINE INCORPORATED | 135,000 | 1,820,000 | 0.07% | ||
| 139 | INSMED INC | 1,247 | 1,811,000 | 0.07% | Put | |
| 140 | AGENUS INC | 2,500 | 1,795,000 | 0.07% | Put | |
| 141 | INTELLIA THERAPEUTICS INC | 104,841 | 1,784,000 | 0.07% | ||
| 142 | ACADIA HEALTHCARE COMPANY IN | 548 | 1,743,000 | 0.07% | Put | |
| 143 | ZOGENIX INC | 150,000 | 1,715,000 | 0.06% | ||
| 144 | HEMISPHERX BIOPHARMA INC | 1,351,850 | 1,690,000 | 0.06% | ||
| 145 | AMICUS THERAPEUTICS INC | 2,282 | 1,689,000 | 0.06% | Put | |
| 146 | NEVRO CORP | 161 | 1,681,000 | 0.06% | Call | |
| 147 | GLOBAL BLOOD THERAPEUTICS INC | 721 | 1,662,000 | 0.06% | Call | |
| 148 | ADVERUM BIOTECHNOLOGIES INC | 402,603 | 1,655,000 | 0.06% | ||
| 149 | EDAP TMS S A SPONSORED ADR | 545,918 | 1,583,000 | 0.06% | ||
| 150 | CYTORI THERAPEUTICS INC | 895,017 | 1,547,000 | 0.06% |
Portfolio data is normalized using SEC Form 13F filings, including the Original 13F-HR (0001144204-16-133740, filed 2016.11.14).
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
