| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 12,339,444 | 73,420,000 | 25.97% | ||
| 2 | Redmile Group, LLC | 5,706,906 | 33,956,000 | 12.01% | ||
| 3 | NEA Management Company, LLC | 5,653,029 | 33,636,000 | 11.90% | ||
| 4 | Palo Alto Investors LP | 1,956,376 | 11,640,000 | 4.12% | ||
| 5 | FRANKLIN RESOURCES INC | 1,873,100 | 11,145,000 | 3.94% | ||
| 6 | VANGUARD GROUP INC | 1,773,331 | 10,551,000 | 3.73% | ||
| 7 | D. E. Shaw & Co., Inc. | 1,505,732 | 8,959,000 | 3.17% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 1,481,034 | 8,812,000 | 3.12% | ||
| 9 | RS INVESTMENT MANAGEMENT CO LLC | 1,248,215 | 7,427,000 | 2.63% | ||
| 10 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 1,231,116 | 7,325,000 | 2.59% | ||
| 11 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 986,000 | 5,867,000 | 2.08% | ||
| 12 | MORGAN STANLEY | 674,039 | 4,010,000 | 1.42% | ||
| 13 | Informed Momentum Co LLC | 612,199 | 3,643,000 | 1.29% | ||
| 14 | Visium Asset Management, LP | 605,731 | 3,604,000 | 1.27% | ||
| 15 | FMR LLC | 562,204 | 3,345,000 | 1.18% | ||
| 16 | Numeric Investors LLC | 524,542 | 3,121,000 | 1.10% | ||
| 17 | TWO SIGMA INVESTMENTS, LP | 484,065 | 2,880,000 | 1.02% | ||
| 18 | BAKER BROS. ADVISORS LP | 481,697 | 2,866,000 | 1.01% | ||
| 19 | DEERFIELD MANAGEMENT COMPANY, L.P. | 480,000 | 2,856,000 | 1.01% | ||
| 20 | PUTNAM INVESTMENTS LLC | 452,200 | 2,691,000 | 0.95% | ||
| 21 | TFS CAPITAL LLC | 420,189 | 2,500,000 | 0.88% | ||
| 22 | SMITH ASSET MANAGEMENT GROUP LP | 367,370 | 2,186,000 | 0.77% | ||
| 23 | SOUND ENERGY PARTNERS, INC. | 261,416 | 1,555,000 | 0.55% | ||
| 24 | RUSSELL FRANK CO/ | 255,742 | 1,522,000 | 0.54% | ||
| 25 | INSIGHT CAPITAL RESEARCH & MANAGEMENT INC | 248,383 | 1,478,000 | 0.52% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 245,581 | 1,461,000 | 0.52% | ||
| 27 | AMERIPRISE FINANCIAL INC | 226,803 | 1,349,000 | 0.48% | ||
| 28 | ClariVest Asset Management LLC | 225,737 | 1,344,000 | 0.48% | ||
| 29 | BLACKROCK ADVISORS LLC | 222,948 | 1,327,000 | 0.47% | ||
| 30 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 215,518 | 1,283,000 | 0.45% | ||
| 31 | TWO SIGMA ADVISERS, LP | 209,073 | 1,244,000 | 0.44% | ||
| 32 | SECTORAL ASSET MANAGEMENT INC | 200,000 | 1,190,000 | 0.42% | ||
| 33 | Point72 Asset Management, L.P. | 195,900 | 1,166,000 | 0.41% | ||
| 34 | DEUTSCHE BANK AG\ | 185,658 | 1,103,000 | 0.39% | ||
| 35 | Bank of New York Mellon Corp | 182,229 | 1,084,000 | 0.38% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 173,500 | 1,032,000 | 0.37% | Call | |
| 37 | GROUP ONE TRADING LLC | 169,135 | 1,006,000 | 0.36% | ||
| 38 | Spark Investment Management LLC | 166,400 | 988,000 | 0.35% | ||
| 39 | Connor, Clark & Lunn Investment Management Ltd. | 136,600 | 813,000 | 0.29% | ||
| 40 | RENAISSANCE TECHNOLOGIES LLC | 130,400 | 776,000 | 0.27% | ||
| 41 | Atika Capital Management LLC | 130,000 | 774,000 | 0.27% | ||
| 42 | BlackRock Fund Advisors | 126,899 | 755,000 | 0.27% | ||
| 43 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 118,000 | 702,000 | 0.25% | ||
| 44 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 116,300 | 692,000 | 0.24% | ||
| 45 | PDT Partners, LLC | 113,300 | 674,000 | 0.24% | ||
| 46 | DEERE & CO | 100,172 | 596,000 | 0.21% | ||
| 47 | Jefferies Group LLC | 100,000 | 595,000 | 0.21% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,900 | 594,000 | 0.21% | Put | |
| 49 | CREDIT SUISSE AG/ | 96,752 | 576,000 | 0.20% | ||
| 50 | Independence Capital Asset Partners, LLC | 92,558 | 551,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
