| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 21,348,929 | 106,103,000 | 13.42% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 17,296,672 | 85,964,000 | 10.87% | ||
| 3 | Redmile Group, LLC | 12,331,130 | 61,286,000 | 7.75% | ||
| 4 | JENNISON ASSOCIATES LLC | 9,277,910 | 46,111,000 | 5.83% | ||
| 5 | VANGUARD GROUP INC | 8,333,811 | 41,419,000 | 5.24% | ||
| 6 | BlackRock Fund Advisors | 7,585,493 | 37,700,000 | 4.77% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 6,891,791 | 34,255,000 | 4.33% | ||
| 8 | Palo Alto Investors LP | 6,410,030 | 31,858,000 | 4.03% | ||
| 9 | STATE STREET CORP | 5,715,947 | 28,386,000 | 3.59% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 5,100,198 | 25,348,000 | 3.21% | ||
| 11 | VICTORY CAPITAL MANAGEMENT INC | 4,075,653 | 20,256,000 | 2.56% | ||
| 12 | Avoro Capital Advisors LLC | 4,017,577 | 19,967,000 | 2.52% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 3,692,098 | 18,350,000 | 2.32% | ||
| 14 | MORGAN STANLEY | 3,073,442 | 15,274,000 | 1.93% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,041,930 | 15,118,000 | 1.91% | ||
| 16 | FRAZIER MANAGEMENT LLC | 2,600,014 | 12,922,000 | 1.63% | ||
| 17 | D. E. Shaw & Co., Inc. | 2,330,599 | 11,583,000 | 1.46% | ||
| 18 | AXA S.A. | 2,168,322 | 10,777,000 | 1.36% | ||
| 19 | FRANKLIN RESOURCES INC | 1,886,300 | 9,375,000 | 1.19% | ||
| 20 | ALLIANCEBERNSTEIN L.P. | 1,804,222 | 8,967,000 | 1.13% | ||
| 21 | Artal Group S.A. | 1,750,000 | 8,698,000 | 1.10% | ||
| 22 | VOYA INVESTMENT MANAGEMENT LLC | 1,654,522 | 8,222,000 | 1.04% | ||
| 23 | NORTHERN TRUST CORP | 1,613,842 | 8,021,000 | 1.01% | ||
| 24 | JPMORGAN CHASE & CO | 1,421,086 | 7,063,000 | 0.89% | ||
| 25 | WELLINGTON MANAGEMENT GROUP LLP | 1,165,137 | 5,791,000 | 0.73% | ||
| 26 | DEUTSCHE BANK AG\ | 1,125,023 | 5,588,000 | 0.71% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 1,115,353 | 5,543,000 | 0.70% | ||
| 28 | NORGES BANK | 1,018,862 | 5,064,000 | 0.64% | ||
| 29 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 985,504 | 4,898,000 | 0.62% | ||
| 30 | Candriam S.C.A. | 861,900 | 4,283,000 | 0.54% | ||
| 31 | Rock Springs Capital Management LP | 757,500 | 3,765,000 | 0.48% | ||
| 32 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 756,596 | 3,760,000 | 0.48% | ||
| 33 | GOLDMAN SACHS GROUP INC | 735,435 | 3,655,000 | 0.46% | ||
| 34 | SPHERA FUNDS MANAGEMENT LTD. | 730,000 | 3,628,000 | 0.46% | ||
| 35 | ELEMENT CAPITAL MANAGEMENT LLC | 664,116 | 3,301,000 | 0.42% | ||
| 36 | Artal Group S.A. | 650,000 | 3,231,000 | 0.41% | Call | |
| 37 | PRUDENTIAL FINANCIAL INC | 602,500 | 2,994,000 | 0.38% | ||
| 38 | Bank of New York Mellon Corp | 597,763 | 2,971,000 | 0.38% | ||
| 39 | ARROWGRASS CAPITAL PARTNERS (US) LP | 572,000 | 2,843,000 | 0.36% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 532,774 | 2,648,000 | 0.33% | ||
| 41 | BlackRock Investment Management, LLC | 527,430 | 2,621,000 | 0.33% | ||
| 42 | HealthCor Management, L.P. | 500,000 | 2,485,000 | 0.31% | Call | |
| 43 | Tekla Capital Management LLC | 418,730 | 2,081,000 | 0.26% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 408,172 | 2,029,000 | 0.26% | ||
| 45 | GW&K Investment Management, LLC | 396,951 | 1,973,000 | 0.25% | ||
| 46 | GROUP ONE TRADING LLC | 357,131 | 1,775,000 | 0.22% | ||
| 47 | PRELUDE CAPITAL MANAGEMENT, LLC | 326,456 | 1,622,000 | 0.21% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 316,500 | 1,573,000 | 0.20% | Call | |
| 49 | CITADEL ADVISORS LLC | 307,051 | 1,526,000 | 0.19% | ||
| 50 | GUGGENHEIM CAPITAL LLC | 306,205 | 1,522,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
