| 1 |
Redmile Group, LLC |
8,496,538 |
17,588,000 |
24.73% |
|
|
| 2 |
NEA Management Company, LLC |
5,653,029 |
11,702,000 |
16.45% |
|
|
| 3 |
Palo Alto Investors LP |
3,971,576 |
8,221,000 |
11.56% |
|
|
| 4 |
RS INVESTMENT MANAGEMENT CO LLC |
2,816,739 |
5,831,000 |
8.20% |
|
|
| 5 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
2,455,400 |
5,083,000 |
7.15% |
|
|
| 6 |
VANGUARD GROUP INC |
1,231,741 |
2,550,000 |
3.59% |
|
|
| 7 |
PERCEPTIVE ADVISORS LLC |
966,300 |
2,000,000 |
2.81% |
|
|
| 8 |
BlackRock Fund Advisors |
854,639 |
1,769,000 |
2.49% |
|
|
| 9 |
D. E. Shaw & Co., Inc. |
660,790 |
1,368,000 |
1.92% |
|
|
| 10 |
SOUND ENERGY PARTNERS, INC. |
595,200 |
1,232,000 |
1.73% |
|
|
| 11 |
FMR LLC |
562,204 |
1,164,000 |
1.64% |
|
|
| 12 |
BAKER BROS. ADVISORS LP |
481,697 |
997,000 |
1.40% |
|
|
| 13 |
PUTNAM INVESTMENTS LLC |
452,200 |
936,000 |
1.32% |
|
|
| 14 |
STATE STREET CORP |
432,456 |
894,000 |
1.26% |
|
|
| 15 |
NORTHERN TRUST CORP |
401,450 |
831,000 |
1.17% |
|
|
| 16 |
ROYCE & ASSOCIATES LP |
313,700 |
649,000 |
0.91% |
|
|
| 17 |
MORGAN STANLEY |
305,789 |
633,000 |
0.89% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
277,718 |
575,000 |
0.81% |
|
|
| 19 |
SMITH ASSET MANAGEMENT GROUP LP |
267,480 |
554,000 |
0.78% |
|
|
| 20 |
TURNER INVESTMENTS LLC |
252,774 |
523,000 |
0.74% |
|
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
221,236 |
458,000 |
0.64% |
|
|
| 22 |
Healthcare Value Capital, LLC |
200,000 |
414,000 |
0.58% |
|
|
| 23 |
BALYASNY ASSET MANAGEMENT L.P. |
194,163 |
402,000 |
0.57% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
160,080 |
331,000 |
0.47% |
|
|
| 25 |
Bank of New York Mellon Corp |
149,822 |
310,000 |
0.44% |
|
|
| 26 |
TFS CAPITAL LLC |
130,876 |
271,000 |
0.38% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
123,481 |
256,000 |
0.36% |
|
|
| 28 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
116,300 |
252,000 |
0.35% |
|
|
| 29 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
121,200 |
251,000 |
0.35% |
|
|
| 30 |
RENAISSANCE TECHNOLOGIES LLC |
121,000 |
250,000 |
0.35% |
|
|
| 31 |
PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC |
109,452 |
227,000 |
0.32% |
|
|
| 32 |
OXFORD ASSET MANAGEMENT LLP |
104,166 |
216,000 |
0.30% |
|
|
| 33 |
AXA S.A. |
97,740 |
202,000 |
0.28% |
|
|
| 34 |
BlackRock Investment Management, LLC |
87,527 |
181,000 |
0.25% |
|
|
| 35 |
CREDIT SUISSE AG/ |
79,592 |
165,000 |
0.23% |
|
|
| 36 |
ALLIANCEBERNSTEIN L.P. |
78,565 |
163,000 |
0.23% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
55,200 |
115,000 |
0.16% |
|
|
| 38 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
54,764 |
113,000 |
0.16% |
|
|
| 39 |
P.R. Herzig & Co. Inc. |
53,000 |
110,000 |
0.15% |
|
|
| 40 |
TWO SIGMA INVESTMENTS, LP |
51,345 |
106,000 |
0.15% |
|
|
| 41 |
BRANDES INVESTMENT PARTNERS, LP |
48,100 |
100,000 |
0.14% |
|
|
| 42 |
TEACHERS ADVISORS, LLC |
45,095 |
93,000 |
0.13% |
|
|
| 43 |
GOLDMAN SACHS GROUP INC |
44,048 |
91,000 |
0.13% |
|
|
| 44 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
36,200 |
75,000 |
0.11% |
Call |
|
| 45 |
BROWN ADVISORY INC |
31,850 |
66,000 |
0.09% |
|
|
| 46 |
ProShare Advisors LLC |
30,782 |
64,000 |
0.09% |
|
|
| 47 |
BLACKROCK ADVISORS LLC |
29,227 |
60,000 |
0.08% |
|
|
| 48 |
RHUMBLINE ADVISERS |
27,686 |
57,000 |
0.08% |
|
|
| 49 |
Nationwide Fund Advisors |
24,464 |
51,000 |
0.07% |
|
|
| 50 |
STONERIDGE INVESTMENT PARTNERS LLC |
24,439 |
51,000 |
0.07% |
|
|
