| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 21,320,863 | 157,774,000 | 14.22% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 14,116,644 | 104,463,000 | 9.41% | ||
| 3 | Redmile Group, LLC | 12,751,536 | 94,361,000 | 8.50% | ||
| 4 | VANGUARD GROUP INC | 7,956,543 | 58,879,000 | 5.31% | ||
| 5 | JENNISON ASSOCIATES LLC | 7,906,476 | 58,508,000 | 5.27% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 7,708,080 | 57,040,000 | 5.14% | ||
| 7 | BlackRock Fund Advisors | 6,634,693 | 49,097,000 | 4.42% | ||
| 8 | Palo Alto Investors LP | 5,685,388 | 42,072,000 | 3.79% | ||
| 9 | STATE STREET CORP | 5,093,598 | 37,694,000 | 3.40% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 4,339,335 | 32,111,000 | 2.89% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 4,194,452 | 31,039,000 | 2.80% | ||
| 12 | VICTORY CAPITAL MANAGEMENT INC | 4,020,283 | 29,750,000 | 2.68% | ||
| 13 | Avoro Capital Advisors LLC | 3,689,857 | 27,305,000 | 2.46% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 3,444,510 | 25,489,000 | 2.30% | ||
| 15 | FRAZIER MANAGEMENT LLC | 2,600,014 | 19,240,000 | 1.73% | ||
| 16 | D. E. Shaw & Co., Inc. | 2,299,071 | 17,013,000 | 1.53% | ||
| 17 | FRANKLIN RESOURCES INC | 1,969,500 | 14,574,000 | 1.31% | ||
| 18 | Artal Group S.A. | 1,900,000 | 14,060,000 | 1.27% | ||
| 19 | ALLIANCEBERNSTEIN L.P. | 1,844,529 | 13,650,000 | 1.23% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 1,638,471 | 12,125,000 | 1.09% | ||
| 21 | CQS Cayman LP | 1,623,000 | 12,010,000 | 1.08% | ||
| 22 | NORTHERN TRUST CORP | 1,600,116 | 11,841,000 | 1.07% | ||
| 23 | EMERALD ADVISERS, LLC | 1,354,790 | 10,025,000 | 0.90% | ||
| 24 | DEUTSCHE BANK AG\ | 1,354,827 | 10,023,000 | 0.90% | ||
| 25 | EMERALD MUTUAL FUND ADVISERS TRUST | 1,270,437 | 9,401,000 | 0.85% | ||
| 26 | WELLINGTON MANAGEMENT GROUP LLP | 1,104,117 | 8,170,000 | 0.74% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 1,069,349 | 7,913,000 | 0.71% | ||
| 28 | Candriam S.C.A. | 986,900 | 7,303,000 | 0.66% | ||
| 29 | Invesco Ltd. | 982,382 | 7,270,000 | 0.66% | ||
| 30 | NORGES BANK | 1,018,862 | 7,201,000 | 0.65% | ||
| 31 | SPHERA FUNDS MANAGEMENT LTD. | 905,000 | 6,697,000 | 0.60% | ||
| 32 | PRUDENTIAL FINANCIAL INC | 754,700 | 5,584,000 | 0.50% | ||
| 33 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 703,372 | 5,205,000 | 0.47% | ||
| 34 | Rock Springs Capital Management LP | 695,000 | 5,143,000 | 0.46% | ||
| 35 | ACUTA CAPITAL PARTNERS, LLC | 670,000 | 4,958,000 | 0.45% | ||
| 36 | Artal Group S.A. | 650,000 | 4,810,000 | 0.43% | Call | |
| 37 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 618,317 | 4,576,000 | 0.41% | ||
| 38 | Bank of New York Mellon Corp | 587,202 | 4,345,000 | 0.39% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 552,100 | 4,086,000 | 0.37% | Call | |
| 40 | Asset Management One Co., Ltd. | 565,245 | 3,996,000 | 0.36% | ||
| 41 | BlackRock Investment Management, LLC | 527,392 | 3,903,000 | 0.35% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 505,081 | 3,738,000 | 0.34% | ||
| 43 | GW&K Investment Management, LLC | 461,446 | 3,415,000 | 0.31% | ||
| 44 | JPMORGAN CHASE & CO | 453,851 | 3,358,000 | 0.30% | ||
| 45 | DIMENSIONAL FUND ADVISORS LP | 450,076 | 3,331,000 | 0.30% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 420,836 | 3,114,000 | 0.28% | ||
| 47 | CITADEL ADVISORS LLC | 378,641 | 2,802,000 | 0.25% | ||
| 48 | GOLDMAN SACHS GROUP INC | 374,769 | 2,773,000 | 0.25% | ||
| 49 | COLUMBUS CIRCLE INVESTORS | 330,996 | 2,449,000 | 0.22% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 301,538 | 2,231,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
