| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 14,794,969 | 206,982,000 | 11.68% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 14,439,444 | 175,633,000 | 9.91% | ||
| 3 | Redmile Group, LLC | 8,332,930 | 116,578,000 | 6.58% | ||
| 4 | SECTORAL ASSET MANAGEMENT INC | 6,111,227 | 85,496,000 | 4.82% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,887,965 | 82,373,000 | 4.65% | ||
| 6 | VANGUARD GROUP INC | 5,812,611 | 81,319,000 | 4.59% | ||
| 7 | BlackRock Fund Advisors | 5,223,201 | 73,073,000 | 4.12% | ||
| 8 | CITADEL ADVISORS LLC | 4,277,283 | 59,839,000 | 3.38% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 4,251,854 | 59,483,000 | 3.36% | ||
| 10 | Avoro Capital Advisors LLC | 4,250,199 | 59,460,000 | 3.35% | ||
| 11 | JENNISON ASSOCIATES LLC | 3,990,817 | 55,832,000 | 3.15% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 3,734,506 | 52,246,000 | 2.95% | ||
| 13 | STATE STREET CORP | 3,387,339 | 47,390,000 | 2.67% | ||
| 14 | RS INVESTMENT MANAGEMENT CO LLC | 2,860,425 | 40,017,000 | 2.26% | ||
| 15 | LORD, ABBETT & CO. LLC | 2,748,548 | 38,452,000 | 2.17% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 2,733,559 | 38,242,000 | 2.16% | ||
| 17 | ALLIANCEBERNSTEIN L.P. | 1,980,077 | 27,701,000 | 1.56% | ||
| 18 | Palo Alto Investors LP | 1,974,376 | 27,622,000 | 1.56% | ||
| 19 | ACUTA CAPITAL PARTNERS, LLC | 1,404,667 | 19,651,000 | 1.11% | ||
| 20 | D. E. Shaw & Co., Inc. | 1,394,515 | 19,509,000 | 1.10% | ||
| 21 | NORTHERN TRUST CORP | 1,263,541 | 17,677,000 | 1.00% | ||
| 22 | FRANKLIN RESOURCES INC | 1,205,900 | 16,871,000 | 0.95% | ||
| 23 | GOLDMAN SACHS GROUP INC | 1,205,114 | 16,860,000 | 0.95% | ||
| 24 | EMERALD ADVISERS, LLC | 1,151,230 | 16,106,000 | 0.91% | ||
| 25 | EMERALD MUTUAL FUND ADVISERS TRUST | 1,034,084 | 14,467,000 | 0.82% | ||
| 26 | WELLINGTON MANAGEMENT GROUP LLP | 998,611 | 13,971,000 | 0.79% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 950,485 | 13,297,000 | 0.75% | ||
| 28 | Candriam S.C.A. | 944,000 | 13,207,000 | 0.75% | ||
| 29 | LOOMIS SAYLES & CO L P | 865,939 | 12,114,000 | 0.68% | ||
| 30 | CITIGROUP INC | 858,581 | 12,011,000 | 0.68% | ||
| 31 | PICTET ASSET MANAGEMENT LTD | 815,523 | 11,409,000 | 0.64% | ||
| 32 | NORGES BANK | 778,747 | 10,895,000 | 0.61% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 749,398 | 10,484,000 | 0.59% | ||
| 34 | Invesco Ltd. | 733,936 | 10,268,000 | 0.58% | ||
| 35 | PUTNAM INVESTMENTS LLC | 727,200 | 10,174,000 | 0.57% | ||
| 36 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 710,953 | 9,946,000 | 0.56% | ||
| 37 | Bank of New York Mellon Corp | 579,743 | 8,111,000 | 0.46% | ||
| 38 | AXA S.A. | 578,343 | 8,091,000 | 0.46% | ||
| 39 | DEUTSCHE BANK AG\ | 544,498 | 7,615,000 | 0.43% | ||
| 40 | Rock Springs Capital Management LP | 455,000 | 6,365,000 | 0.36% | ||
| 41 | PRUDENTIAL FINANCIAL INC | 444,500 | 6,218,000 | 0.35% | ||
| 42 | JPMORGAN CHASE & CO | 433,039 | 6,058,000 | 0.34% | ||
| 43 | BlackRock Investment Management, LLC | 388,287 | 5,432,000 | 0.31% | ||
| 44 | Connor, Clark & Lunn Investment Management Ltd. | 382,959 | 5,358,000 | 0.30% | ||
| 45 | GILDER GAGNON HOWE & CO LLC | 381,695 | 5,340,000 | 0.30% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 367,284 | 5,138,000 | 0.29% | ||
| 47 | FRED ALGER MANAGEMENT, LLC | 362,934 | 5,077,000 | 0.29% | ||
| 48 | Asset Management One Co., Ltd. | 381,295 | 4,941,000 | 0.28% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 348,106 | 4,871,000 | 0.27% | ||
| 50 | ROYCE & ASSOCIATES LP | 334,000 | 4,673,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
