| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 14,439,444 | 204,318,000 | 12.57% | ||
| 2 | FMR LLC | 13,100,348 | 185,370,000 | 11.41% | ||
| 3 | Redmile Group, LLC | 6,297,523 | 89,110,000 | 5.48% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,824,300 | 82,414,000 | 5.07% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 5,019,702 | 71,029,000 | 4.37% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 5,004,322 | 70,811,000 | 4.36% | ||
| 7 | Avoro Capital Advisors LLC | 4,590,199 | 64,951,000 | 4.00% | ||
| 8 | CITADEL ADVISORS LLC | 3,965,272 | 56,109,000 | 3.45% | ||
| 9 | BlackRock Fund Advisors | 3,550,362 | 50,238,000 | 3.09% | ||
| 10 | JENNISON ASSOCIATES LLC | 3,371,995 | 47,714,000 | 2.94% | ||
| 11 | VANGUARD GROUP INC | 3,288,076 | 46,526,000 | 2.86% | ||
| 12 | STATE STREET CORP | 3,277,039 | 46,369,000 | 2.85% | ||
| 13 | JANUS HENDERSON INVESTORS US LLC | 2,907,661 | 41,143,000 | 2.53% | ||
| 14 | RS INVESTMENT MANAGEMENT CO LLC | 2,687,065 | 38,022,000 | 2.34% | ||
| 15 | Palo Alto Investors LP | 1,974,376 | 27,937,000 | 1.72% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 1,884,381 | 26,664,000 | 1.64% | ||
| 17 | FRANKLIN RESOURCES INC | 1,807,400 | 25,575,000 | 1.57% | ||
| 18 | ACUTA CAPITAL PARTNERS, LLC | 1,775,000 | 25,116,000 | 1.55% | ||
| 19 | D. E. Shaw & Co., Inc. | 1,630,724 | 23,075,000 | 1.42% | ||
| 20 | GOLDMAN SACHS GROUP INC | 1,198,149 | 16,954,000 | 1.04% | ||
| 21 | Candriam S.C.A. | 1,170,000 | 16,555,000 | 1.02% | ||
| 22 | EMERALD ADVISERS, LLC | 1,099,630 | 15,560,000 | 0.96% | ||
| 23 | PICTET ASSET MANAGEMENT LTD | 860,586 | 14,794,000 | 0.91% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,031,900 | 14,601,000 | 0.90% | ||
| 25 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,011,539 | 14,313,276 | 0.88% | ||
| 26 | LORD, ABBETT & CO. LLC | 1,007,002 | 14,249,000 | 0.88% | ||
| 27 | WELLINGTON MANAGEMENT GROUP LLP | 988,200 | 13,983,000 | 0.86% | ||
| 28 | Point72 Asset Management, L.P. | 916,700 | 12,971,000 | 0.80% | ||
| 29 | LOOMIS SAYLES & CO L P | 856,318 | 12,117,000 | 0.75% | ||
| 30 | EMERALD MUTUAL FUND ADVISERS TRUST | 793,662 | 11,230,000 | 0.69% | ||
| 31 | PUTNAM INVESTMENTS LLC | 727,200 | 10,290,000 | 0.63% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 701,256 | 9,922,000 | 0.61% | ||
| 33 | Connor, Clark & Lunn Investment Management Ltd. | 691,934 | 9,791,000 | 0.60% | ||
| 34 | ARROWGRASS CAPITAL PARTNERS (US) LP | 598,064 | 8,463,000 | 0.52% | ||
| 35 | Bank of New York Mellon Corp | 581,953 | 8,234,000 | 0.51% | ||
| 36 | GILDER GAGNON HOWE & CO LLC | 540,524 | 7,648,000 | 0.47% | ||
| 37 | Informed Momentum Co LLC | 514,470 | 7,280,000 | 0.45% | ||
| 38 | SPHERA FUNDS MANAGEMENT LTD. | 450,000 | 6,368,000 | 0.39% | ||
| 39 | FRED ALGER MANAGEMENT, LLC | 432,186 | 6,115,000 | 0.38% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 402,100 | 5,690,000 | 0.35% | Put | |
| 41 | ROYCE & ASSOCIATES LP | 380,000 | 5,377,000 | 0.33% | ||
| 42 | Rock Springs Capital Management LP | 377,500 | 5,342,000 | 0.33% | ||
| 43 | Ghost Tree Capital, LLC | 375,000 | 5,306,000 | 0.33% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 357,600 | 5,060,000 | 0.31% | Call | |
| 45 | APIS CAPITAL ADVISORS, LLC | 353,000 | 4,995,000 | 0.31% | ||
| 46 | Asset Management One Co., Ltd. | 364,534 | 4,968,000 | 0.31% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 328,777 | 4,652,000 | 0.29% | ||
| 48 | BlackRock Investment Management, LLC | 327,335 | 4,632,000 | 0.29% | ||
| 49 | MARSHALL WACE, LLP | 325,268 | 4,603,000 | 0.28% | ||
| 50 | HIGHLAND CAPITAL MANAGEMENT LP | 321,336 | 4,547,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
