| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PERCEPTIVE ADVISORS LLC | 14,439,444 | 157,101,000 | 17.29% | ||
| 2 | Redmile Group, LLC | 5,832,228 | 63,455,000 | 6.98% | ||
| 3 | SECTORAL ASSET MANAGEMENT INC | 4,986,138 | 54,249,000 | 5.97% | ||
| 4 | MILLENNIUM MANAGEMENT LLC | 4,316,935 | 46,968,000 | 5.17% | ||
| 5 | Avoro Capital Advisors LLC | 4,211,399 | 45,820,000 | 5.04% | ||
| 6 | CITADEL ADVISORS LLC | 3,920,077 | 42,650,000 | 4.69% | ||
| 7 | D. E. Shaw & Co., Inc. | 2,569,326 | 27,954,000 | 3.08% | ||
| 8 | RS INVESTMENT MANAGEMENT CO LLC | 2,564,545 | 27,902,000 | 3.07% | ||
| 9 | VANGUARD GROUP INC | 2,550,728 | 27,752,000 | 3.05% | ||
| 10 | STATE STREET CORP | 2,431,229 | 26,452,000 | 2.91% | ||
| 11 | ACUTA CAPITAL PARTNERS, LLC | 1,964,565 | 21,374,000 | 2.35% | ||
| 12 | Palo Alto Investors LP | 1,956,376 | 21,285,000 | 2.34% | ||
| 13 | FRANKLIN RESOURCES INC | 1,954,400 | 21,264,000 | 2.34% | ||
| 14 | GOLDMAN SACHS GROUP INC | 1,501,433 | 16,336,000 | 1.80% | ||
| 15 | BALYASNY ASSET MANAGEMENT L.P. | 1,436,694 | 15,631,000 | 1.72% | ||
| 16 | BlackRock Fund Advisors | 1,359,173 | 14,788,000 | 1.63% | ||
| 17 | Candriam S.C.A. | 1,350,000 | 14,691,000 | 1.62% | ||
| 18 | MARSHALL WACE, LLP | 1,195,514 | 13,007,000 | 1.43% | ||
| 19 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,146,506 | 12,473,985 | 1.37% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 1,141,356 | 12,418,000 | 1.37% | ||
| 21 | MORGAN STANLEY | 1,039,535 | 11,310,000 | 1.24% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,010,000 | 10,989,000 | 1.21% | ||
| 23 | Connor, Clark & Lunn Investment Management Ltd. | 836,609 | 9,102,000 | 1.00% | ||
| 24 | PUTNAM INVESTMENTS LLC | 727,200 | 7,912,000 | 0.87% | ||
| 25 | LORD, ABBETT & CO. LLC | 689,719 | 7,504,000 | 0.83% | ||
| 26 | EMERALD ADVISERS, LLC | 702,309 | 7,487,000 | 0.82% | ||
| 27 | Independence Capital Asset Partners, LLC | 665,671 | 7,243,000 | 0.80% | ||
| 28 | Informed Momentum Co LLC | 625,694 | 6,808,000 | 0.75% | ||
| 29 | PRICE T ROWE ASSOCIATES INC /MD/ | 621,249 | 6,759,000 | 0.74% | ||
| 30 | EMERALD MUTUAL FUND ADVISERS TRUST | 581,562 | 6,199,000 | 0.68% | ||
| 31 | FMR LLC | 562,204 | 6,117,000 | 0.67% | ||
| 32 | Forward Management, LLC | 636,880 | 6,046,000 | 0.67% | ||
| 33 | PICTET ASSET MANAGEMENT LTD | 594,209 | 5,978,000 | 0.66% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 466,252 | 5,073,000 | 0.56% | ||
| 35 | OXFORD ASSET MANAGEMENT LLP | 458,701 | 4,991,000 | 0.55% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 454,600 | 4,946,000 | 0.54% | Put | |
| 37 | SPHERA FUNDS MANAGEMENT LTD. | 450,000 | 4,896,000 | 0.54% | ||
| 38 | DEUTSCHE BANK AG\ | 445,147 | 4,841,000 | 0.53% | ||
| 39 | Numeric Investors LLC | 434,900 | 4,732,000 | 0.52% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 407,731 | 4,436,000 | 0.49% | ||
| 41 | FRED ALGER MANAGEMENT, LLC | 402,068 | 4,374,000 | 0.48% | ||
| 42 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 363,197 | 3,952,000 | 0.44% | ||
| 43 | Ghost Tree Capital, LLC | 350,000 | 3,808,000 | 0.42% | ||
| 44 | MILLENNIUM MANAGEMENT LLC | 300,000 | 3,264,000 | 0.36% | Call | |
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 289,334 | 3,148,000 | 0.35% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 285,700 | 3,108,000 | 0.34% | Call | |
| 47 | CREDIT SUISSE AG/ | 265,718 | 2,891,000 | 0.32% | ||
| 48 | COLUMBUS CIRCLE INVESTORS | 260,945 | 2,839,000 | 0.31% | ||
| 49 | JPMORGAN CHASE & CO | 253,449 | 2,758,000 | 0.30% | ||
| 50 | Bank of New York Mellon Corp | 244,962 | 2,665,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
