| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 19,023,053 | 103,865,000 | 13.23% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 15,239,444 | 83,207,000 | 10.60% | ||
| 3 | Redmile Group, LLC | 11,106,446 | 60,641,000 | 7.73% | ||
| 4 | VANGUARD GROUP INC | 7,033,500 | 38,404,000 | 4.89% | ||
| 5 | PICTET ASSET MANAGEMENT LTD | 4,707,381 | 33,328,000 | 4.25% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,883,948 | 32,126,000 | 4.09% | ||
| 7 | BlackRock Fund Advisors | 5,785,314 | 31,588,000 | 4.03% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 5,562,366 | 30,370,000 | 3.87% | ||
| 9 | JENNISON ASSOCIATES LLC | 5,147,214 | 28,104,000 | 3.58% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 4,788,738 | 26,147,000 | 3.33% | ||
| 11 | STATE STREET CORP | 4,480,616 | 24,463,000 | 3.12% | ||
| 12 | Palo Alto Investors LP | 4,009,375 | 21,891,000 | 2.79% | ||
| 13 | Avoro Capital Advisors LLC | 3,698,665 | 20,195,000 | 2.57% | ||
| 14 | RS INVESTMENT MANAGEMENT CO LLC | 3,429,187 | 18,723,000 | 2.39% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 3,240,568 | 17,694,000 | 2.25% | ||
| 16 | D. E. Shaw & Co., Inc. | 2,775,593 | 15,155,000 | 1.93% | ||
| 17 | FRAZIER MANAGEMENT LLC | 2,725,591 | 14,882,000 | 1.90% | ||
| 18 | ALLIANCEBERNSTEIN L.P. | 2,102,242 | 11,478,000 | 1.46% | ||
| 19 | FRANKLIN RESOURCES INC | 1,969,500 | 10,753,000 | 1.37% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 1,910,196 | 10,430,000 | 1.33% | ||
| 21 | NORTHERN TRUST CORP | 1,435,680 | 7,839,000 | 1.00% | ||
| 22 | CQS Cayman LP | 1,390,000 | 7,589,000 | 0.97% | ||
| 23 | Artal Group S.A. | 1,250,000 | 6,825,000 | 0.87% | ||
| 24 | ACUTA CAPITAL PARTNERS, LLC | 1,161,545 | 6,342,000 | 0.81% | ||
| 25 | EMERALD MUTUAL FUND ADVISERS TRUST | 1,104,827 | 6,032,000 | 0.77% | ||
| 26 | WELLINGTON MANAGEMENT GROUP LLP | 1,089,017 | 5,946,000 | 0.76% | ||
| 27 | EMERALD ADVISERS, LLC | 1,056,583 | 5,769,000 | 0.74% | ||
| 28 | SPHERA FUNDS MANAGEMENT LTD. | 1,005,000 | 5,487,000 | 0.70% | ||
| 29 | JPMORGAN CHASE & CO | 992,689 | 5,420,000 | 0.69% | ||
| 30 | PRUDENTIAL FINANCIAL INC | 937,580 | 5,119,000 | 0.65% | ||
| 31 | DEUTSCHE BANK AG\ | 857,628 | 4,680,000 | 0.60% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 856,747 | 4,677,000 | 0.60% | ||
| 33 | NORGES BANK | 851,030 | 4,647,000 | 0.59% | ||
| 34 | Candriam S.C.A. | 709,900 | 3,876,000 | 0.49% | ||
| 35 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 691,659 | 3,776,000 | 0.48% | ||
| 36 | Rock Springs Capital Management LP | 680,000 | 3,713,000 | 0.47% | ||
| 37 | Bank of New York Mellon Corp | 649,235 | 3,545,000 | 0.45% | ||
| 38 | CITADEL ADVISORS LLC | 580,934 | 3,172,000 | 0.40% | ||
| 39 | Asset Management One Co., Ltd. | 560,274 | 3,036,000 | 0.39% | ||
| 40 | BlackRock Investment Management, LLC | 472,055 | 2,577,000 | 0.33% | ||
| 41 | GW&K Investment Management, LLC | 468,708 | 2,559,000 | 0.33% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 459,801 | 2,511,000 | 0.32% | ||
| 43 | DIMENSIONAL FUND ADVISORS LP | 435,736 | 2,379,000 | 0.30% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 392,451 | 2,143,000 | 0.27% | ||
| 45 | Nicholas Investment Partners, LP | 317,716 | 1,735,000 | 0.22% | ||
| 46 | BALYASNY ASSET MANAGEMENT L.P. | 300,000 | 1,638,000 | 0.21% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 277,500 | 1,515,000 | 0.19% | Call | |
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 276,800 | 1,511,000 | 0.19% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 267,038 | 1,458,000 | 0.19% | ||
| 50 | Tekla Capital Management LLC | 258,000 | 1,409,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
