| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 18,723,103 | 158,211,000 | 13.19% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 15,239,444 | 128,773,000 | 10.74% | ||
| 3 | Redmile Group, LLC | 10,718,420 | 90,571,000 | 7.55% | ||
| 4 | SECTORAL ASSET MANAGEMENT INC | 9,226,145 | 77,961,000 | 6.50% | ||
| 5 | VANGUARD GROUP INC | 6,509,450 | 55,005,000 | 4.59% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,901,048 | 49,864,000 | 4.16% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 5,616,508 | 47,461,000 | 3.96% | ||
| 8 | BlackRock Fund Advisors | 5,444,399 | 46,005,000 | 3.84% | ||
| 9 | JENNISON ASSOCIATES LLC | 5,141,046 | 43,442,000 | 3.62% | ||
| 10 | STATE STREET CORP | 3,819,430 | 32,271,000 | 2.69% | ||
| 11 | Palo Alto Investors LP | 3,551,173 | 30,007,000 | 2.50% | ||
| 12 | RS INVESTMENT MANAGEMENT CO LLC | 3,527,703 | 29,809,000 | 2.49% | ||
| 13 | Avoro Capital Advisors LLC | 3,424,104 | 28,934,000 | 2.41% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 2,927,472 | 24,737,000 | 2.06% | ||
| 15 | FRAZIER MANAGEMENT LLC | 2,918,291 | 24,660,000 | 2.06% | ||
| 16 | D. E. Shaw & Co., Inc. | 2,903,472 | 24,535,000 | 2.05% | ||
| 17 | ACUTA CAPITAL PARTNERS, LLC | 2,500,000 | 21,125,000 | 1.76% | ||
| 18 | EMERALD MUTUAL FUND ADVISERS TRUST | 2,053,225 | 17,350,000 | 1.45% | ||
| 19 | FRANKLIN RESOURCES INC | 1,969,500 | 16,642,000 | 1.39% | ||
| 20 | EMERALD ADVISERS, LLC | 1,897,821 | 16,037,000 | 1.34% | ||
| 21 | MORGENTHALER MANAGEMENT PARTNERS IX, LLC | 1,783,948 | 15,074,000 | 1.26% | ||
| 22 | ALLIANCEBERNSTEIN L.P. | 1,778,151 | 15,025,000 | 1.25% | ||
| 23 | VOYA INVESTMENT MANAGEMENT LLC | 1,345,146 | 11,367,000 | 0.95% | ||
| 24 | NORTHERN TRUST CORP | 1,317,542 | 11,134,000 | 0.93% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,243,700 | 10,509,000 | 0.88% | Call | |
| 26 | JPMORGAN CHASE & CO | 1,138,342 | 9,619,000 | 0.80% | ||
| 27 | Invesco Ltd. | 1,099,329 | 9,289,000 | 0.77% | ||
| 28 | GOLDMAN SACHS GROUP INC | 1,067,034 | 9,017,000 | 0.75% | ||
| 29 | WELLINGTON MANAGEMENT GROUP LLP | 1,038,773 | 8,778,000 | 0.73% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 841,457 | 7,110,000 | 0.59% | ||
| 31 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 714,977 | 6,042,000 | 0.50% | ||
| 32 | NORGES BANK | 680,030 | 5,746,000 | 0.48% | ||
| 33 | Candriam S.C.A. | 619,900 | 5,210,000 | 0.43% | ||
| 34 | PRUDENTIAL FINANCIAL INC | 614,300 | 5,191,000 | 0.43% | ||
| 35 | Rock Springs Capital Management LP | 613,500 | 5,184,000 | 0.43% | ||
| 36 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 595,060 | 5,028,000 | 0.42% | ||
| 37 | Asset Management One Co., Ltd. | 589,121 | 4,707,000 | 0.39% | ||
| 38 | Bank of New York Mellon Corp | 542,020 | 4,580,000 | 0.38% | ||
| 39 | HIGHLAND CAPITAL MANAGEMENT LP | 521,900 | 4,410,000 | 0.37% | ||
| 40 | PICTET ASSET MANAGEMENT LTD | 607,500 | 3,742,000 | 0.31% | ||
| 41 | GW&K Investment Management, LLC | 417,435 | 3,527,000 | 0.29% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 411,111 | 3,474,000 | 0.29% | ||
| 43 | BlackRock Investment Management, LLC | 396,235 | 3,348,000 | 0.28% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 353,065 | 2,983,000 | 0.25% | ||
| 45 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 333,513 | 2,818,000 | 0.23% | ||
| 46 | DEUTSCHE BANK AG\ | 327,427 | 2,766,000 | 0.23% | ||
| 47 | SPHERA FUNDS MANAGEMENT LTD. | 300,000 | 2,535,000 | 0.21% | ||
| 48 | GUGGENHEIM CAPITAL LLC | 299,607 | 2,532,000 | 0.21% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 279,400 | 2,361,000 | 0.20% | ||
| 50 | Tekla Capital Management LLC | 258,000 | 2,180,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
