| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 18,734,915 | 181,729,000 | 13.29% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 15,239,444 | 147,823,000 | 10.81% | ||
| 3 | Redmile Group, LLC | 10,280,620 | 99,722,000 | 7.30% | ||
| 4 | SECTORAL ASSET MANAGEMENT INC | 7,973,436 | 77,342,000 | 5.66% | ||
| 5 | VANGUARD GROUP INC | 6,227,567 | 60,408,000 | 4.42% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,929,068 | 57,512,000 | 4.21% | ||
| 7 | BlackRock Fund Advisors | 5,360,745 | 51,999,000 | 3.80% | ||
| 8 | STATE STREET CORP | 5,156,858 | 50,024,000 | 3.66% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 5,094,434 | 49,416,000 | 3.62% | ||
| 10 | JENNISON ASSOCIATES LLC | 4,123,955 | 40,002,000 | 2.93% | ||
| 11 | Palo Alto Investors LP | 3,551,173 | 34,446,000 | 2.52% | ||
| 12 | Avoro Capital Advisors LLC | 3,515,611 | 34,101,000 | 2.49% | ||
| 13 | RS INVESTMENT MANAGEMENT CO LLC | 3,488,863 | 33,842,000 | 2.48% | ||
| 14 | D. E. Shaw & Co., Inc. | 3,425,496 | 33,227,000 | 2.43% | ||
| 15 | ALLIANCEBERNSTEIN L.P. | 2,192,974 | 30,680,000 | 2.24% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 2,974,625 | 28,854,000 | 2.11% | ||
| 17 | FRAZIER MANAGEMENT LLC | 2,918,291 | 28,307,000 | 2.07% | ||
| 18 | FRANKLIN RESOURCES INC | 1,969,500 | 19,104,000 | 1.40% | ||
| 19 | EMERALD MUTUAL FUND ADVISERS TRUST | 1,965,578 | 19,066,000 | 1.39% | ||
| 20 | MORGENTHALER MANAGEMENT PARTNERS IX, LLC | 1,783,948 | 17,304,000 | 1.27% | ||
| 21 | EMERALD ADVISERS, LLC | 1,734,566 | 16,825,000 | 1.23% | ||
| 22 | ACUTA CAPITAL PARTNERS, LLC | 1,502,661 | 14,576,000 | 1.07% | ||
| 23 | GOLDMAN SACHS GROUP INC | 1,399,794 | 13,578,000 | 0.99% | ||
| 24 | NORTHERN TRUST CORP | 1,298,508 | 12,595,000 | 0.92% | ||
| 25 | WELLINGTON MANAGEMENT GROUP LLP | 1,039,603 | 10,084,000 | 0.74% | ||
| 26 | PICTET ASSET MANAGEMENT LTD | 963,635 | 9,347,000 | 0.68% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 956,185 | 9,275,000 | 0.68% | ||
| 28 | JPMORGAN CHASE & CO | 914,799 | 8,874,000 | 0.65% | ||
| 29 | VOYA INVESTMENT MANAGEMENT LLC | 873,861 | 8,477,000 | 0.62% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 808,008 | 7,837,000 | 0.57% | ||
| 31 | Invesco Ltd. | 772,661 | 7,495,000 | 0.55% | ||
| 32 | DEUTSCHE BANK AG\ | 769,252 | 7,459,000 | 0.55% | ||
| 33 | Candriam S.C.A. | 764,000 | 7,411,000 | 0.54% | ||
| 34 | PUTNAM INVESTMENTS LLC | 727,200 | 7,054,000 | 0.52% | ||
| 35 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 706,045 | 6,848,000 | 0.50% | ||
| 36 | NORGES BANK | 680,030 | 6,596,000 | 0.48% | ||
| 37 | PRUDENTIAL FINANCIAL INC | 614,700 | 5,963,000 | 0.44% | ||
| 38 | OXFORD ASSET MANAGEMENT LLP | 614,976 | 5,956,000 | 0.44% | ||
| 39 | Rock Springs Capital Management LP | 566,500 | 5,495,000 | 0.40% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 556,700 | 5,400,000 | 0.40% | Call | |
| 41 | Bank of New York Mellon Corp | 549,126 | 5,327,000 | 0.39% | ||
| 42 | Asset Management One Co., Ltd. | 521,606 | 5,028,000 | 0.37% | ||
| 43 | A.R.T. Advisors, LLC | 511,384 | 4,960,000 | 0.36% | ||
| 44 | GROUP ONE TRADING LLC | 404,791 | 3,926,000 | 0.29% | ||
| 45 | BlackRock Investment Management, LLC | 390,174 | 3,785,000 | 0.28% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 367,696 | 3,567,000 | 0.26% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 357,920 | 3,472,000 | 0.25% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 326,100 | 3,163,000 | 0.23% | ||
| 49 | GUGGENHEIM CAPITAL LLC | 290,868 | 2,821,000 | 0.21% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 252,400 | 2,448,000 | 0.18% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
